Volume 22 Issue 11
Nov.  2024
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LI Yun, CHANG Wenjing, ZHANG Xudong, ZHANG Juwen, CHEN Wei. Clinical efficacy and safety of Xiao' er Chaigui Tuire Granules in the treatment of acute upper respiratory tract infection: a meta-analysis[J]. Chinese Journal of General Practice, 2024, 22(11): 1957-1962. doi: 10.16766/j.cnki.issn.1674-4152.003774
Citation: LI Yun, CHANG Wenjing, ZHANG Xudong, ZHANG Juwen, CHEN Wei. Clinical efficacy and safety of Xiao' er Chaigui Tuire Granules in the treatment of acute upper respiratory tract infection: a meta-analysis[J]. Chinese Journal of General Practice, 2024, 22(11): 1957-1962. doi: 10.16766/j.cnki.issn.1674-4152.003774
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Clinical efficacy and safety of Xiao' er Chaigui Tuire Granules in the treatment of acute upper respiratory tract infection: a meta-analysis

doi: 10.16766/j.cnki.issn.1674-4152.003774

  • Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Funds:

 ZYYCXTD-D-202208

  • Received Date: 2023-10-09
    Available Online: 2024-12-31
    Abstract
  •   Objective  To systematically evaluate the clinical efficacy and safety of Xiao' er Chaigui Tuire Granules alone or combined with Western medicine in the treatment of acute upper respiratory tract infection, and to provide evidence-based basis for clinical application.  Methods  The clinical literatures on the application of Xiao' er Chaigui Tuire Granules were searched in CNKI, Wanfang, VIP, SinoMed, PubMed and Cochrane Library, and the retrieval time was established until January 2023. Data extraction were extracted from the included literatures, and methodological quality assessment tools were used to evaluate literature quality. Meta-analysis was performed using RevMan 5.4 software.  Results  A total of 2 913 patients were included in 20 randomized controlled trials. The results of meta-analysis showed that Xiao' er Chaigui Tuire Granules combined with ribavirin could shorten the antipyretic time [MD=-0.75(d), 95% CI: -1.00 to-0.50, P < 0.001], Xiao' er Chaigui Tuire Granules combined with amoxicillin could also shorten the antipyretic time [MD=-1.78(h), 95% CI: -2.07 to-1.48, P < 0.001]. Compared with the conventional antibiotics and antiviral agents, Xiao' er Chaigui Tuire Granules could shorten the antipyretic time [MD=-0.95(d), 95% CI: -1.44 to-0.46, P < 0.001]. Compared with ribavirin, the therapeutic indexes of Xiao' er Chaigui Tuire Granules alone had no obvious advantage.  Conclusion  Xiao' er Chaigui Tuire Granules combined with Western medicine has a good therapeutic effect, whereas the number and quality of the relevant clinical studies remain to be improved. The process of clinical trial should be standardized to improve the quality of evidence, so to guide the better application of Xiao' er Chaigui Tuire Granules in clinical practice.

     

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