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XU Xiaoran, YANG Zihan, NING Jing, SUN Futongyu, TAN Xi. Mendelian randomization study of eczema and depression[J]. Chinese Journal of General Practice, 2024, 22(12): 2012-2015. doi: 10.16766/j.cnki.issn.1674-4152.003786
Citation: XU Xiaoran, YANG Zihan, NING Jing, SUN Futongyu, TAN Xi. Mendelian randomization study of eczema and depression[J]. Chinese Journal of General Practice, 2024, 22(12): 2012-2015. doi: 10.16766/j.cnki.issn.1674-4152.003786
shu

Mendelian randomization study of eczema and depression

doi: 10.16766/j.cnki.issn.1674-4152.003786
  • 1.

    Academy of Life Science, Beijing University of Chinese Medicine, Beijing 100029, China

Funds:

 81973978

 JCYJ20210324135413036

  • Received Date: 2024-05-12
    Available Online: 2025-01-20
    Abstract
  •   Objective  The relationship between eczema and depression has received much attention, yet the causal association between the two is unclear. Therefore, Mendelian randomization (MR) was used to investigate whether there is a causal relationship between eczema and depression.  Methods  Genotypic data of eczema and depression were selected from the publicly available pooled dataset of the Genome-wide association study (GWAS), with eczema as the exposure factor and depression as the outcome variable. The selected samples were genotyped using MR, where the instrumental variables were genetic loci with a strong correlation with eczema disease. The odds ratio (OR) was used as an estimator, and the effect value β judged the direction of the association between the two. Heterogeneity test, sensitivity analysis, and horizontal multiple validity test were also performed.  Results  Inverse variance weighted method analysis showed a positive correlation between eczema and the occurrence of depression and yielded an OR of 1.011, 95% CI: 1.001-1.022, P=0.037; weighted median regression analysis yielded similar results (OR=1.012, 95% CI: 1.001-1.023, P=0.029). Cochran ' s Q test showed significant heterogeneity of the results (P < 0.05), but the analysis of the random effects model yielded P=0.037 and β=0.011, which proved that there was a positive causal relationship. In addition, no horizontal pleiotropy was observed for the funnel plot and Mr-Egger intercept.  Conclusion  The findings suggest a possible positive causal relationship between eczema and the occurrence of depression.

     

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