Volume 22 Issue 12
Dec.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(12): 2100-2103
JIANG Ruiting, NI Qichao, WANG Yujia, MIN Jingjing. Serum NSE levels in epileptic patients and its correlation with EEG characteristics and recurrence risk[J]. Chinese Journal of General Practice, 2024, 22(12): 2100-2103. doi: 10.16766/j.cnki.issn.1674-4152.003807
Citation: JIANG Ruiting, NI Qichao, WANG Yujia, MIN Jingjing. Serum NSE levels in epileptic patients and its correlation with EEG characteristics and recurrence risk[J]. Chinese Journal of General Practice, 2024, 22(12): 2100-2103. doi: 10.16766/j.cnki.issn.1674-4152.003807
shu

Serum NSE levels in epileptic patients and its correlation with EEG characteristics and recurrence risk

doi: 10.16766/j.cnki.issn.1674-4152.003807

  • Department of Electroencephalogram Room, Huzhou First People's Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2021KY1097

 2019GYB06

  • Received Date: 2024-04-02
    Available Online: 2025-01-20
    Abstract
  •   Objective   To detect the level of serum neuron-specific enolase (NSE) in patients with epilepsy, and analyze their correlation with electroencephalogram (EEG) characteristics, as well as identify predictive factors for epilepsy recurrence.   Methods   A total of 95 epileptic patients admitted to Huzhou First People's Hospital from January 2021 to February 2023 were selected as the research group and 30 healthy people were selected as the control group during the same period. Serum NSE levels were detected by enzyme-linked immunosorbent assay, and the correlation between serum NSE levels and EEG was analyzed by Kendall's correlation. After a one-year follow-up, patients with epilepsy in the research group were divided into a non-recurrence group (n=41) and a recurrence group (n=52). The influencing factors of epilepsy recurrence were analyzed by multivariate logistic regression.   Results   The levels of serum NSE, galanin (GAL), and TNF-α in the research group were higher than those in the control group (P < 0.05). The levels of serum NSE, GAL, and TNF-α in different EEG abnormal groups were significantly different (P < 0.05). Kendall's correlation analysis showed positive correlations between NSE, GAL, and TNF-α and the degree of EEG abnormality (P < 0.05). The recurrence group showed significant differences in the number of anti-epileptic drugs taken and the levels of serum NSE, GAL, and TNF-α compared to the non-relapse group (P < 0.05). Multivariate logistic regression analysis showed that higher levels of NSE (OR=1.259) and TNF-α (OR=1.097) were independent risk factors for the recurrence of epilepsy (P < 0.05). The ROC curve analysis showed that the AUC of 0.859 (95% CI: 0.786-0.932) for NSE and 0.703 (95% CI: 0.594-0.811) for TNF-α.   Conclusion   The higher serum NSE levels are associated with higher EEG abnormalities in epileptic patients. Serum NSE levels have a high predictive value for epileptic recurrence and can serve as an independent predictive index of recurrence risk.

     

    • FullText(HTML)
  • loading
    • References(23)
  • [1]
    LIU J Q, ZHANG P, ZOU Q, et al. Status of epilepsy in the tropics: An overlooked perspective[J]. Epilepsia Open, 2023, 8(1): 32-45. doi: 10.1002/epi4.12686
    [2]
    刘志敏, 桑琳霞, 李文玲, 等. 难治性癫痫患者外科治疗后延续性护理效果及其复发的影响因素[J]. 实用心脑肺血管病杂志, 2023, 31(12): 134-136, 140.

    LIU Z M, SANG L X, LI W L, et al. Effect of continuous nursing care for patients with intractable epilepsy after surgical treatment and influencing factors of recurrence[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2023, 31(12): 134-136, 140.
    [3]
    王满利, 章晓富, 樊玉香, 等. 癫痫患者血清长链非编码RNA母系表达基因3、miR-7-5p表达与认知功能的关系[J]. 中国卫生检验杂志, 2022, 32(24): 2998-3002.

    WANG M L, ZHANG X F, FAN Y X, et al. Relationship between maternal expression of long-chain noncoding RNA gene 3 and miR-7-5p in serum and cognitive function in epileptic patients[J]. Chinese Journal of Health Laboratory Technology, 2022, 32(24): 2998-3002.
    [4]
    韩长明, 彭福来, 陈财, 等. 基于脑电信号的癫痫发作预测研究进展[J]. 生物医学工程学杂志, 2021, 38(6): 1193-1202.

    HAN C M, PENG F L, CHEN C, et al. Research progress of epileptic seizure prediction based on EEG[J]. Journal of Biomedical Engineering, 2021, 38(6): 1193-1202.
    [5]
    HANIN A, LAMBRECQ V, DENIS J A, et al. Cerebrospinal fluid and blood biomarkers of status epilepticus[J]. Epilepsia, 2020, 61(1): 6-18. doi: 10.1111/epi.16405
    [6]
    KIRMANI B F, AU K, AYARI L, et al. Super-refractory status epilepticus: prognosis and recent advances in management[J]. Aging Dis, 2021, 12(4): 1097-1119. doi: 10.14336/AD.2021.0302
    [7]
    ALKHACHROUM A, DER-NIGOGHOSSIAN C A, RUBINOS C, et al. Markers in status epilepticus prognosis[J]. J Clin Neurophysiol, 2020, 37(5): 422-428. doi: 10.1097/WNP.0000000000000761
    [8]
    中国抗癫痫协会. 临床诊疗指南-癫痫病分册[M]. 2版. 北京: 人民卫生出版社, 2015: 82.

    China Anti-Epilepsy Association. Clinical diagnosis and treatment guidelines-epilepsy fascicle[M]. 2nd edition. Beijing: People's Medical Publishing House, 2015: 82.
    [9]
    SPECCHIO N, WIRRELL E C, SCHEFFER I E, et al. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: position paper by the iLAE task force on nosology and definitions[J]. Epilepsia, 2022, 63(6): 1398-1442. doi: 10.1111/epi.17241
    [10]
    VANABELLE P, DE HANDSCHUTTER P, EL TAHRY R, et al. Epileptic seizure detection using EEG signals and extreme gradient boosting[J]. J Biomed Res, 2019, 34(3): 228-239.
    [11]
    刘毅, 郑艳. 济南市癫痫患儿流行病学调查研究与护理防范对策[J]. 护理实践与研究, 2019, 16(12): 8-9.

    LIU Y, ZHENG Y. Epidemiological investigation and nursing countermeasures of children with epilepsy in Jinan[J]. Nursing Practice and Research, 2019, 16(12): 8-9.
    [12]
    吴雪梅, 王海艳. 癫痫患者共患焦虑和抑郁现状调查及其危险因素分析[J]. 中华全科医学, 2022, 20(11): 1969-1972. doi: 10.16766/j.cnki.issn.1674-4152.002748

    WU X M, WANG H Y. Investigation of anxiety and depression in epilepsy patients and analysis of risk factors[J]. Chinese Journal of General Practice, 2022, 20(11): 1969-1972. doi: 10.16766/j.cnki.issn.1674-4152.002748
    [13]
    LEE S A, IM K, CHOI E J, et al. Concealment behaviors in Korean adults with epilepsy: their relationships to social anxiety and seizure severity independent of felt stigma[J]. Epilepsy Behav, 2022, 129(1): 108647. DOI: 10.1016/j.yebeh.2022.108647.
    [14]
    LONG X Y, WANG S, LUO Z W, et al. Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid[J]. World J Psychiatry, 2020, 10(7): 150-161. doi: 10.5498/wjp.v10.i7.150
    [15]
    KILIÇ H, YILMAZ K, UYUR YALÇIN E, et al. Are interictal discharges associated with neuronal cell loss in electrical status epilepticus in sleep?[J]. Turk Arch Pediatr, 2022, 57(6): 611-615. doi: 10.5152/TurkArchPediatr.2022.22151
    [16]
    KONG Y, CHENG N, DANG N, et al. Application of combined multimodal neuroimaging and video-electroencephalography in intractable epilepsy patients for improved post-surgical outcome prediction[J]. Clin Radiol, 2022, 77(3): e250-e259. doi: 10.1016/j.crad.2021.12.013
    [17]
    DE STEFANO P, SEECK M, ROSSETTI A O. Critical care EEG standardized nomenclature in clinical practice: strengths, limitations, and outlook on the example of prognostication after cardiac arrest[J]. Clin Neurophysiol Pract, 2021, 6(1): 149-154.
    [18]
    阮卫云, 李卫征, 郭燕燕. 脑电图联合血清神经元特异性烯醇化酶、胶质纤维蛋白和S-100β对癫痫病情评估的意义[J]. 中华生物医学工程杂志, 2021, 27(2): 198-200.

    RUAN W Y, LI W Z, GUO Y Y. The significance of EEG combined with serum neuron-specific enolase, glial fibrillin and S-100β in the evaluation of epilepsy[J]. Chinese Journal of Biomedical Engineering, 2021, 27(2): 198-200.
    [19]
    VAN DER LENDE M, ARENDS J B, LAMBERTS R J, et al. The yield of long-term electrocardiographic recordings in refractory focal epilepsy[J]. Epilepsia, 2019, 60(11): 2215-2223. doi: 10.1111/epi.16373
    [20]
    HANIN A, DEMERET S, DENIS J A, et al. Serum neuron-specific enolase: a new tool for seizure risk monitoring after status epilepticus[J]. Eur J Neurol, 2022, 29(3): 883-889. doi: 10.1111/ene.15154
    [21]
    孙威, 慕洁. 癫痫持续状态的脑脊液和血液生物标志物[J]. 癫痫杂志, 2021, 7(4): 367-378.

    SUN W, MU J. Cerebrospinal fluid and blood biomarkers in status epilepticus[J]. Journal of Epilepsy, 2021, 7(4): 367-378.
    [22]
    CHEN Y, NAGIB M M, YASMEN N, et al. Neuroinflammatory mediators in acquired epilepsy: an update[J]. Inflamm Res, 2023, 72(4): 683-701.
    [23]
    张菲菲, 程艳伟, 石向群. 大鼠癫痫持续状态后海马TNF-α、IL-1β的动态变化[J]. 中国神经精神疾病杂志, 2017, 43(6): 362-367.

    ZHANG F F, CHENG Y W, SHI X Q. Dynamic changes of TNF-α and IL-1β in hippocampus of rats with epileptic status[J]. Chinese Journal of Nervous and Mental Diseases, 2017, 43(6): 362-367.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(6)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (17) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return