Volume 23 Issue 2
Feb.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(2): 235-238
WANG Qiaohong, CHEN Xingxing, ZHU Weimin, GAN Huiling, XU Xianxian, BIAN Bingbing, LI Ping, YANG Peng, SHAN Renfei, JIANG Yongpo. Impact of platelet transfusion on the prognosis of patients with sepsis: a propensity score matching analysis[J]. Chinese Journal of General Practice, 2025, 23(2): 235-238. doi: 10.16766/j.cnki.issn.1674-4152.003875
Citation: WANG Qiaohong, CHEN Xingxing, ZHU Weimin, GAN Huiling, XU Xianxian, BIAN Bingbing, LI Ping, YANG Peng, SHAN Renfei, JIANG Yongpo. Impact of platelet transfusion on the prognosis of patients with sepsis: a propensity score matching analysis[J]. Chinese Journal of General Practice, 2025, 23(2): 235-238. doi: 10.16766/j.cnki.issn.1674-4152.003875
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Impact of platelet transfusion on the prognosis of patients with sepsis: a propensity score matching analysis

doi: 10.16766/j.cnki.issn.1674-4152.003875

  • Department of Emergency, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang 318050, China

Funds:

 2022KY435

 23ywa47

  • Received Date: 2024-01-25
    Available Online: 2025-03-27
    Abstract
  •   Objective  Thrombocytopenia is one of the common complications in patients with sepsis.Platelet transfusions are frequently administered to increase platelet counts, however, their clinical impacts in sepsis-induced thrombocytopenia remains unclear.This article discusses the impact of platelet transfusion on the prognosis of patients with sepsis.  Methods  Patients with sepsis admitted to the ICU of Taizhou Hospital from January 2019 to December 2021 were selected as the study subjects.According to the platelet transfusion at ICU admission, septic patients were divided into two groups: a platelet transfusion group (PT group) and a non-platelet transfusion group (NPT group).Propensity score matching (PSM 1:1) was used to balance the groups.Cox logistic regression model and Kaplan-Meier survival analysis were used to analyze the impact of platelet transfusion on the prognosis in patients with sepsis.  Results  A total of 274 patients with sepsis were included in the study, with 57 patients in the platelet transfusion group.After PSM, 38 patients were matched in each group.The primary outcomes were 28-day and 90-day mortalities, which were 31.6%(12/38) and 36.8%(14/38) in the PT group, respectively, compared to 36.8%(14/38) and 39.5%(15/38) in the NPT group, with no significant difference (P>0.05).Kaplan-Meier survival analysis showed no significant difference in the 28-day and 90-day cumulative survival rates of patients between the platelet transfusion group and the NPT group (P>0.05).The Cox logistic regression model showed the APACHE Ⅱ score (HR=1.138, 95%CI: 1.066-1.215, P < 0.05) as an independent factor influencing prognosis in sepsis patients, while platelet transfusion (HR=0.457, 95%CI: 0.182-1.146, P>0.05) was not a significant factor.  Conclusion  This study found that the APACHE Ⅱ score is an independent factor for 28-day mortality in septic patients, while platelet transfusion does not improve the prognosis of patients with sepsis.

     

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