Volume 23 Issue 2
Feb.  2025
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ZHOU Fangfang, SHANG Lili, WANG Jiejie. Analysis of therapeutic effect of added flavor of Maxing Shigan Decoction combined with acupoint application in the treatment of Mycoplasma pneumoniae pneumonia in children[J]. Chinese Journal of General Practice, 2025, 23(2): 253-256. doi: 10.16766/j.cnki.issn.1674-4152.003879
Citation: ZHOU Fangfang, SHANG Lili, WANG Jiejie. Analysis of therapeutic effect of added flavor of Maxing Shigan Decoction combined with acupoint application in the treatment of Mycoplasma pneumoniae pneumonia in children[J]. Chinese Journal of General Practice, 2025, 23(2): 253-256. doi: 10.16766/j.cnki.issn.1674-4152.003879
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Analysis of therapeutic effect of added flavor of Maxing Shigan Decoction combined with acupoint application in the treatment of Mycoplasma pneumoniae pneumonia in children

doi: 10.16766/j.cnki.issn.1674-4152.003879

  • Department of Pediatrics, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230000, China

Funds:

 2023ZYLCYJ05-05

  • Received Date: 2024-06-28
    Available Online: 2025-03-27
    Abstract
  •   Objective  To explore the clinical efficacy and safety of combing traditional Chinese medicine internal treatment and external treatment (Maxing Shigan Decoction combined with acupoint application) in the treatment of Mycoplasma pneumoniae pneumonia in children.  Methods  A retrospective analysis was conducted on 108 children with Mycoplasma pneumoniae pneumonia admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine between January 2023 and May 2024.The participants were divided into an observation group and a control group using the random number table method, with 54 cases in each group.The children in each group were treated with conventional Western medicine.The observation group was treated with Maxing Shigan Decoction combined with Feishu acupoint application on the basis of the control group for 7-14 days.The study assessed the improvement in traditional Chinese medicine (TCM) syndrome scores, clinical symptoms (cough, fever, and lung rales), length of hospital stay, clinical efficacy, incidence of RMPP and SMPP, adverse drug reactions, and serum inflammatory factor levels.  Results  The observation group showed a significantly lower TCM syndrome score compared to the control group (P < 0.05).The observation group also showed shorter remission time of cough, disappearance of pulmonary rales, duration of fever, and a shorter length of hospital stay, compared to the control group (P < 0.05).There was significant difference in clinical efficacy between the two groups (Z=-2.392, P=0.017).The observation group showed higher levels of IL-6, CRP, and PCT compared to the control group (P < 0.05).There was no significant difference in the occurrence of RMPP and SMPP between the two groups (P>0.05).No statistically significant difference was observed in the incidence of adverse drug reactions between the two groups (P>0.05).  Conclusion  The combined application of Maxing Shigan Decoction and acupoint application in the treatment of Mycoplasma pneumoniae pneumonia in children effectively reduces inflammation in the body, improves clinical symptoms, lowers TCM syndrome scores, with a significant therapeutic effect and good safety profile.

     

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    • References(26)
  • [1]
    冶雪凤, 沈红, 星学花, 等. 血清炎症因子与难治性支原体肺炎患儿凝血状态相关性分析[J]. 临床军医杂志, 2022, 50(7): 760-762.

    YE X F, SHEN H, XING X H, et al. Correlation between serum inflammatory factors and coagulation status in children with refractory mycoplasma pneumonia[J]. Journal of Clinical Military Medicine, 2022, 50(7): 760-762.
    [2]
    DAI F F, LIU F Q, CHEN X, et al. The treatment of macrolideresistant Mycoplasma pneumoniae pneumonia in children[J]. J Clin Pharm Ther, 2021, 46(3): 705-710. doi: 10.1111/jcpt.13331
    [3]
    殷勇, 陈健德. 儿童大环内酯类耐药肺炎支原体肺炎诊疗理念与实践[J]. 临床儿科杂志, 2024, 42(3): 177-180.

    YIN Y, CHEN J D. Diagnosis and treatment of macrolide resistant mycoplasma pneumoniae pneumonia in children[J]. Journal of Clinical Pediatrics, 2024, 42(3): 177-180.
    [4]
    贺杰, 张新萍, 赵文姣, 等. 儿童大环内酯类耐药肺炎支原体肺炎临床特征分析[J]. 儿科药学杂志, 2022, 28(8): 36-39.

    HE J, ZHANG X P, ZHAO W J, et al. Clinical characteristics of macrolide resistant mycoplasma pneumoniae pneumonia in children[J]. Pediatric Pharmacy, 2022, 28(8): 36-39.
    [5]
    熊兴江. 基于重症病例及现代病理生理机制的小柴胡汤合麻杏石甘汤方证条文内涵解读及其治疗肺部感染、慢性阻塞性肺疾病急性加重等急危重症体会[J]. 中国中药杂志, 2023, 48(10): 2606-2612.

    XIONG X J. Based on severe cases and modern pathophysiological mechanism, Xiaochaihu Decoction combined with Maxingshigan Decoction and its treatment of acute severe diseases such as pulmonary infection and acute exacerbation of chronic obstructive pulmonary disease[J]. Chinese Journal of Traditional Chinese Medicine, 2023, 48(10): 2606-2612.
    [6]
    李倩, 肖臻, 姜之炎, 等. 穴位敷贴治疗小儿支气管哮喘急性发作期的研究现状及机制探讨[J]. 中国中医基础医学杂志, 2023, 29(7): 1230-1235.

    TAN C F, HUO H M, LIU J H, et al. Effect of acupoint application on mycoplasma pneumonia in children and its effect on serum inflammatory factors and immune function[J]. Journal of Basic Chinese Medicine, 2023, 29(7): 1230-1235.
    [7]
    胡亚美, 江载芳. 诸福棠实用儿科学[M]. 7版. 北京: 人民卫生出版, 2002: 1204-1205.

    HU Y M, JIANG Z F. Zhu Futang Practical Pediatrics[M]. 7th edition. Beijing: People' s Health Publishing, 2002: 1204-1205.
    [8]
    郑筱萸. 中药新药临床研究指导原则: 试行[M]. 北京: 中国医药科技出版社, 2002: 272-276.

    ZHENG X Y. Guiding principles for clinical research of new Chinese medicine: Trial implementation[M]. Beijing: China Medical Science and Technology Press, 2002: 272-276.
    [9]
    马融, 胡思源. 儿科疾病中医药临床研究技术要点[M]. 北京: 中国医药科技出版社, 2011: 51.

    MA R, HU S Y. Key points of TCM clinical research in Pediatric diseases[M]. Beijing: China Medical Science and Technology Press, 2011: 51.
    [10]
    李威, 谢晓恬. 大环内酯类抗生素耐药儿童肺炎支原体感染药物治疗进展[J]. 世界临床药物, 2021, 42(12): 1049-1055.

    LI W, XIE X T. Progress in drug treatment of mycoplasma pneumoniae infection with macrolide antibiotic resistance in children[J]. World Clinical Medicines, 2021, 42(12): 1049-1055.
    [11]
    蔡袁, 王甜, 黄忠. 血清单核细胞趋化蛋白-4、C-反应蛋白、乳酸脱氢酶联合预测重症肺炎支原体肺炎患儿心肌损害的效果[J]. 中国临床医生杂志, 2024, 52(4): 474-477.

    CAI Y, WANG T, HUANG Z. Effect of serum monocyte chemotactic protein-4, C-reactive protein and lactate dehydrogenase in predicting myocardial damage in children with severe mycoplasma pneumonia[J]. Chin J Clinician, 2024, 52(4): 474-477.
    [12]
    贺卫超, 张旭杰, 王帅. 黄连解毒汤加减联合红霉素治疗难治性支原体肺炎的临床分析[J]. 吉林医学, 2020, 41(12): 2955-2957.

    HE W C, ZHANG X J, WANG S. Clinical analysis of Huanglian Jiedu Decoction combined with erythromycin in the treatment of refractory mycoplasma pneumonia[J]. Jilin Medical Journal, 2020, 41(12): 2955-2957.
    [13]
    ZHAO J, LI Y Y, ZHANG W. The clinical significance of IL-6s and IL-27s in bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia[J]. BMC Infect Dis, 2020, 20(1): 331.
    [14]
    孙景巍, 彭万胜, 黄玉柱, 等. 小儿肺炎支原体肺炎合并全身炎症反应综合征时超敏CRP、PCT、WBC变化及临床意义研究[J]. 中华全科医学, 2019, 17(2): 245-247. doi: 10.16766/j.cnki.issn.1674-4152.000651

    SUN J W, PENG W S, HUANG Y Z, et al. Changes and clinical significance of hypersensitive CRP, PCT and WBC in children with mycoplasma pneumoniae pneumonia complicated with systemic inflammatory response syndrome[J]. Chinese Journal of General Practice, 2019, 17(2): 245-247. doi: 10.16766/j.cnki.issn.1674-4152.000651
    [15]
    胡霖, 付白娣. D-D PCIS评分与肺炎支原体肺炎患儿生化指标的相关性及其在病情评估中的价值[J]. 安徽医学, 2022, 43(12): 1442-1445.

    HU L, FU B D. Correlation between D-D PCIS score and biochemical indexes of children with mycoplasma pneumoniae pneumonia and its value in disease assessment[J]. Journal of Anhui Medicine, 2022, 43(12): 1442-1445.
    [16]
    邹清华, 彭宜红. 肺部感染的微生物谱变迁[J]. 临床内科杂志, 2024, 41(3): 145-148.

    ZOU Q H, PENG Y H. Changes of microbiota in pulmonary infection[J]. Journal of Clinical Internal Medicine, 2024, 41(3): 145-148.
    [17]
    吴莉城, 杨亭, 邵征洋. 咳嗽1号方辅助治疗儿童肺炎支原体肺炎痰热闭肺证的临床疗效观察及对血清IL-6、TNF-α的影响[J]. 中国中医药科技, 2024, 31(3): 446-449.

    WU L C, YANG T, SHAO Z Y. Clinical effect of cough No. 1 formula in the adjuvant treatment of pneumococcal pneumonia in children with phlegm-heat blocking lung syndrome and its influence on serum IL-6 and TNF-α[J]. Chinese Journal of Traditional Medical Science and Technology, 2024, 31(3): 446-449.
    [18]
    庞晓妍, 牛艳美, 朱莉莉. 麻杏石甘汤联合头孢哌酮钠舒巴坦钠治疗脑卒中气管切开术后肺部感染患者效果观察[J]. 湖北中医药大学学报, 2023, 25(4): 22-25.

    PANG X Y, NIU Y M, ZHU L L. Effect of Maxingshigan Decoction combined with cefoperazone sodium and sulbactam sodium in the treatment of pulmonary infection after tracheotomy in stroke patients[J]. Journal of Hubei University of Chinese Medicine, 2023, 25(4): 22-25.
    [19]
    刘晓彤, 陈维捷, 李焕坤. 化裁麻杏石甘汤加减治疗喘息性肺炎风热闭肺证的临床效果及对炎症因子的影响[J]. 新疆医科大学学报, 2023, 46(12): 1675-1679.

    LIU X T, CHEN W J, LI H K. Clinical effect of Huaxingshigan Decoction in the treatment of wind-heat blocking lung syndrome of asthmatic pneumonia and its influence on inflammatory factors[J]. Journal of Xinjiang Medical University, 2023, 46(12): 1675-1679.
    [20]
    马媛虹, 程淼, 李长安, 等. 麻杏石甘汤辅助治疗肺系疾病的研究[J]. 世界中医药, 2023, 18(18): 2696-2700.

    MA Y H, CHENG M, LI C A, et al. Study on auxiliary treatment of pulmonary diseases by Maxingshigan Decoction[J]. World of Chinese Medicine, 2023, 18(18): 2696-2700.
    [21]
    LI Y, CHU F H, LI P, et al. Potential effect of Maxingshigan Decotion agaist coronavirus disease 2019(CO-VID-19) revealed by network pharmacology and exper-imental verification[J]. J Ethnopharmacol, 2021, 271: 113854. DOI: 10.1016/j.jep.2021.113854.
    [22]
    卓小玉, 陈晶, 田明, 等. 麻黄的化学成分与药理作用研究进展[J]. 中医药信息, 2021, 38(2): 80-83.

    ZHOU X Y, CHEN J, TIAN M, et al. Research progress on chemical constituents and pharmacological effects of ephedra[J]. Information of Chinese Medicine, 2021, 38(2): 80-83.
    [23]
    张德珂, 聂金娥, 钱芳芳. 中药苦杏仁药理作用研究进展[J]. 山东化工, 2021, 50(22): 100-105.

    ZHANG D K, NIE J E, QIAN F F. Research progress on pharmacological effects of Chinese herbal medicine almond[J]. Shandong Chemical Industry, 2021, 50(22): 100-105.
    [24]
    何凤诗, 杨鹏, 卢栋明, 等. 从"肺"论述麻杏石甘汤在小儿疾病中的应用及其药理研究进展[J]. 广西医学, 2022, 44(9): 1022-1025.

    HE F S, YANG P, LU D M, et al. The application and pharmacological research progress of Maxingshigan Decoction in children disease from the perspective of lung[J]. Guangxi Medical Journal, 2022, 44(9): 1022-1025.
    [25]
    王书玲, 侯江红, 张岩, 等. 苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺证难治性肺炎支原体肺炎[J]. 中国实验方剂学杂志, 2020, 26(10): 69-74.

    WANG S L, HOU J H, ZHANG Y, et al. Weijian Decoction combined with Maxingshigan Decoction combined with half dose of hormone in treatment of refractory mycoplasma pneumoniae pneumonia in children with toxic heat blocking lung syndrome[J]. Chinese Journal of Experimental Formulae, 2020, 26(10): 69-74.
    [26]
    闫春梅, 袁小霞. 中药口服联合穴位贴敷治疗小儿重症肺炎疗效研究[J]. 湖北中医药大学学报, 2024, 26(2): 67-70.

    YAN C M, YUAN X X. Effect of oral Chinese medicine combined with acupoint application in treatment of severe pneumonia in children[J]. Journal of Hubei University of Chinese Medicine, 2024, 26(2): 67-70.
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