Volume 23 Issue 2
Feb.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(2): 296-299
FAN Tiansong, WANG Peidong, PENG Yanyan, HANG Weihong, MA Xiao. Research progress of hyperhomocysteinemia and general practice[J]. Chinese Journal of General Practice, 2025, 23(2): 296-299. doi: 10.16766/j.cnki.issn.1674-4152.003889
Citation: FAN Tiansong, WANG Peidong, PENG Yanyan, HANG Weihong, MA Xiao. Research progress of hyperhomocysteinemia and general practice[J]. Chinese Journal of General Practice, 2025, 23(2): 296-299. doi: 10.16766/j.cnki.issn.1674-4152.003889
shu

Research progress of hyperhomocysteinemia and general practice

doi: 10.16766/j.cnki.issn.1674-4152.003889
  • 1.

    First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China

Funds:

 20CX9ZA029

  • Received Date: 2024-02-05
    Available Online: 2025-03-27
    Abstract
  • Hyperhomocysteinemia is a disease state defined by elevated plasma concentrations of homocysteine. Hyperhomocysteinemia has the potential to cause damage to numerous systems within the human body, including the cardiovascular, cerebrovascular, nervous and endocrine systems. Additionally, it has been linked to adverse pregnancy outcomes and fetal malformations. The field of general practice encompasses the study of all diseases affecting all organ systems in all populations. Consequently, general practice must address health issues at all stages of the life cycle. The impact of hyperhomocysteinemia on the human body is extensive, encompassing diseases of different systems in all age groups and being inextricably linked to numerous areas of general practice. In accordance with the primary ailments addressed in general medical practice as outlined in the 2022 Edition of the Content and Standards for Standardized Residency Training, published by the Chinese Medical Doctor Association, the following conditions are of particular relevance: the early stages of disease and health issues, prevalent, and recurrent illnesses within primary care, and clinical scenarios involving multiple concurrent diseases. This paper presents a comprehensive overview of the latest developments in the field of hyperhomocysteinemia and their implications for general practice. The objective is to enhance the awareness of hyperhomocysteinemia among General Practitioners and the wider community. This will facilitate the avoidance or reduction of the occurrence and development of diseases caused by hyperhomocysteinemia through the implementation of early prevention and intervention strategies, and the maintenance of population health through the provision of regular follow-up care for high-risk groups, This will enable general practitioners to assume the role of "gatekeepers" of population health. It is recommended that relevant departments and social organizations devote greater attention to hyperhomocysteinemia when formulating corresponding policies, guidelines and consensus. Furthermore, they should advocate for high-risk groups to enhance health management, cultivate positive lifestyles, prioritize disease prevention and proactively maintain and promote residents ' health. In the meantime, the research value of hyperhomocysteinemia must be further developed. This paper provides a new research direction for the continued study of hyperhomocysteinemia.

     

    • FullText(HTML)
  • loading
    • References(44)
  • [1]
    SITDIKOVA G, HERMANN A. Homocysteine: biochemistry, molecular biology, and role in disease 2021[J]. Biomolecules, 2023, 13(7): 1111. DOI: 10.3390/biom13071111.
    [2]
    SKOU S T, MAIR F S, FORTIN M, et al. Multimorbidity[J]. Nat Rev Dis Primers, 2022, 8(1): 48. DOI: 10.1038/s41572-022-00376-4.
    [3]
    中国医师协会. 《住院医师规范化培训内容与标准(2022年版)》[EB/OL]. (2022-08-05)[2023-09-01]. https://www.ccgmecmda.cn/news/151117/article.

    CHINESE MEDICAL DOCTOR ASSOCIATION. The contents and standards of standardized training for hospital physicians (2022 edition)[EB/OL]. (2022-08-05)[2023-09-01]. https://www.ccgmecmda.cn/news/151117/article.
    [4]
    闫晗, 向瑞, 杨吉春, 等. 同型半胱氨酸代谢与疾病[J]. 生理科学进展, 2023, 54(4): 290-296.

    YAN H, XIANG R, YANG J C, et al. Homocysteine metabolism and disease[J]. Progress in Physiological Sciences, 2023, 54(4): 290-296.
    [5]
    李东晓, 张尧, 张宏武, 等. 高同型半胱氨酸血症的诊断、治疗与预防专家共识[J]. 罕少疾病杂志, 2022, 29(6): 1-4.

    LI D X, ZHANG Y, ZHANG H W, et al. The expert consensus on the diagnosis, treatment, and prevention of hyperhomocysteinemia[J]. Journal of Rare and Uncommon Diseases, 2022, 29(6): 1-4.
    [6]
    MAJUMDER A. Targeting homocysteine and hydrogen sulfide balance as future therapeutics in cancer treatment[J]. Antioxidants (Basel), 2023, 12(8): 1520. DOI: 10.3390/antiox12081520.
    [7]
    BAJIC Z, SOBOT T, SKRBIC R, et al. Homocysteine, vitamins B6 and folic acid in experimental models of myocardial infarction and heart failure-How strong is that link?[J]. Biomolecules, 2022, 12(4): 536. DOI: 10.3390/biom12040536.
    [8]
    徐柏榕, 田晶, 牛栋, 等. 复方丹参滴丸联合常规西医治疗冠心病合并糖尿病有效性及安全性的meta分析[J]. 中药新药与临床药理, 2024, 35(2): 280-290.

    XU B R, TIAN J, NIU D, et al. Efficacy and safety of compound danshen dripping pills combined with conventional western medicine in the treatment of coronary heart disease complicated with diabetes mellitus: A Meta-analysis[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2024, 35(2): 280-290.
    [9]
    张玉强, 王金宝, 李鑫, 等. 冠状动脉CT血管造影、血清Hcy和胱抑素C水平对无症状冠心病的诊断价值[J]. 广西医学, 2023, 45(1): 30-33.

    ZHANG Y Q, WANG J B, LI X, et al. Value of coronary CT angiography, serum Hcy level and cystatin C level on the diagnosis of asymptomatic coronary heart disease[J]. Guangxi Medical Journal, 2023, 45(1): 30-33.
    [10]
    曹延广, 董黎强, 王斌, 等. 绝经后H型高血压合并骨质疏松症患者高敏C反应蛋白、白细胞介素6和同型半胱氨酸水平与骨代谢标志物的关系[J]. 中华高血压杂志, 2021, 29(6): 567-571.

    CAO Y G, DONG L Q, WANG B, et al. Relationship between high-sensitivity C-reactive protein, interleukin 6 and homocysteine levels and bone metabolic markers in postmenopausal patients with H-type hypertension combined with osteoporosis[J]. Chin J Hypertens, 2021, 29(6): 567-571.
    [11]
    Assessing national capacity for the prevention and control of noncommunicable diseases: report of the 2021 global survey[M]. Geneva: World Health Organization, 2023.
    [12]
    国家卫生健康委员会. 2022年中国卫生健康统计年鉴[M]. 北京: 中国协和医科大学出版社, 2022: 283-299.

    National Health Commission of People ' s Republic of China. China Health Statistics Yearbook 2022[M]. Beijing: Peking Union Medical College Press, 2022: 283-299.
    [13]
    YUAN S, MASON A M, CARTER P, et al. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study[J]. BMC Med, 2021, 19(1): 97. DOI: 10.1186/s12916-021-01977-8.
    [14]
    SONG S, SONG B M, PARK H Y. Associations of serum folate and homocysteine concentrations with all-cause, cardiovascular disease, and cancer mortality in men and women in Korea: the cardiovascular disease association study[J]. J Nutr, 2023, 153(3): 760-770. doi: 10.1016/j.tjnut.2023.01.023
    [15]
    宋忠阳, 王功臣, 张志明, 等. 补阳还五汤联合BMSCs对心肌缺血再灌注损伤模型大鼠心肌的防护作用[J]. 北京中医药大学学报, 2020, 43(2): 115-124.

    SONG Z Y, WANG G C, ZHANG Z M, et al. Buyang Huanwu Decoction ' s protective effect on myocardium and influence on BMSCs migration in myocardial ischemia/reperfusion rats[J]. Journal of Beijing University of Traditional Chinese Medicine, 2020, 43(2): 115-124.
    [16]
    宋忠阳, 陈玉婵, 雍文兴, 等. 补阳还五汤预处理对心肌缺血再灌注损伤大鼠抗氧化功能的影响[J]. 中国中医基础医学杂志, 2020, 26(11): 1621-1625.

    SONG Z Y, CHEN Y C, YONG W X, et al. Effects of Buyang Huanwu Decoction pretreatment on antioxidant function in rats with myocardial ischemia-reperfusion injury[J]. Journal of Basic Chinese Medicine, 2020, 26(11): 1621-1625.
    [17]
    师千与, 程全成, 陈春花. 缺血性脑卒中与血管性痴呆在发病机制上的联系[J]. 解剖学报, 2021, 52(5): 834-838.

    SHI Q Y, CHENG Q C, CHEN C H. Relationship of pathogenesis between ischemic stroke and vascular dementia[J]. Acta Anatomica Sinica, 2021, 52(5): 834-838.
    [18]
    YUAN X J, WANG T C, GAO J, et al. Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population[J]. Clin Exp Hypertens, 2020, 42(1): 52-60.
    [19]
    SMITH A D, REFSUM H. Homocysteine-from disease biomarker to disease prevention[J]. J Intern Med, 2021, 290(4): 826-854.
    [20]
    FAN F F, DAVID SPENCE J, HUO Y. Beyond hypertension: hypertension with hyperhomocysteinemia[J]. Sci Bull, 2023, 68(18): 1975-1977.
    [21]
    王吉静, 徐金义, 张恒源, 等. 心率加速力及心率减速力与高血压患者24 h动态血压昼夜节律变化的关系[J]. 中华高血压杂志, 2024, 32(1): 65-70.

    WANG J J, XU J Y, ZHANG H Y, et al. Heart rate acceleration and deceleration capacities associated with 24-hour circadian blood pressure variation in hypertensive patients[J]. Chin J Hypertens, 2024, 32(1): 65-70.
    [22]
    王吉耀, 葛均波, 邹和建. 实用内科学[M]. 16版. 北京: 人民卫生出版社, 2022: 866-869.

    WANG J Y, GE J B, Zou H J. Practical of Internal Medicine[M]. 16th edition. Beijing. People ' s Medical Publishing House, 2022: 866-869.
    [23]
    张峰, 杨军, 董天崴, 等. 黑龙江省寒地高血压患者MTHFR A1298C基因多态性及其与血清同型半胱氨酸水平的关系[J]. 中国老年学杂志, 2023, 43(2): 266-269.

    ZHANG F, YANG J, DONG T W, et al. MTHFR A1298C gene polymorphism and its relationship with serum homocysteine levels in hypertensive patients in the cold region of Heilongjiang province[J]. Chinese Journal of Gerontology, 2023, 43(2): 266-269.
    [24]
    WAN C, ZONG R Y, CHEN X S. The new mechanism of cognitive decline induced by hypertension: high homocysteine-mediated aberrant DNA methylation[J]. Front Cardiovasc Med, 2022, 24(9): 928701. DOI: 10.3389/fcvm.2022.928701.
    [25]
    ZHAO W Y, GAO F L, LV L D, et al. The interaction of hypertension and homocysteine increases the risk of mortality among middle-aged and older population in the United States[J]. J Hypertens, 2022, 40(2): 254-263.
    [26]
    王宪, 冯娟. 免疫代谢与血管重塑-高同型半胱氨酸血症的作用[J]. 中国科学: 生命科学, 2022, 52(5): 740-747.

    WANG X, FENG J. Immune metabolism and vascular remodeling-The role of hyperhomocysteinemia[J]. Scientia Sinica (Vitae), 2022, 52(5): 740-747.
    [27]
    孙洪霞, 李楠. 孕中晚期血糖血脂水平与巨大儿发生风险的相关性研究[J]. 国际检验医学杂志, 2023, 44(22): 2779-2782.

    SUN H X, LI N. Correlation between blood glucose and lipids levels in the middle-late stages of pregnancy and macrosomia[J]. International Journal of Laboratory Medicine, 2023, 44(22): 2779-2782.
    [28]
    SHEN Z L, ZHANG Z M, ZHAO W J. Relationship between plasma homocysteine and chronic kidney disease in US patients with type 2 diabetes mellitus: a cross-sectional study[J]. BMC Nephrol, 2022, 23(1): 419. DOI: 10.1186/s12882-022-03045-6.
    [29]
    MUZUROVIĆ E, KRALJEVIĆ I, SOLAK M, et al. Homocysteine and diabetes: role in macrovascular and microvascular complications[J]. J Diabetes Complications, 2021, 35(3): 107834. DOI: 10.1016/j.jdiacomp.2020.107834.
    [30]
    杨光, 徐陈陈, 王佳炜, 等. 帕金森病患者血清同型半胱氨酸及血脂水平与脑白质病变的相关性研究[J]. 中华全科医学, 2021, 19(9): 1451-1454, 1503. doi: 10.16766/j.cnki.issn.1674-4152.002083

    YANG G, XU C C, WANG J W, et al. Study on the correlation between serum homocysteine and blood lipid levels and white matter lesions in patients with Parkinson ' s disease[J]. Chinese Journal of General Practice, 2021, 19(9): 1451-1454, 1503. doi: 10.16766/j.cnki.issn.1674-4152.002083
    [31]
    FAN X Y, ZHANG L X, LI H J, et al. Role of homocysteine in the development and progression of Parkinson ' s disease[J]. Ann Clin Transl Neurol, 2020, 7(11): 2332-2338.
    [32]
    TAWFIK A, ELSHERBINY N M, ZAIDI Y, et al. Homocysteine and age-related central nervous system diseases: role of Inflammation[J]. Int J Mol Sci, 2021, 22(12): 6259. DOI: 10.3390/ijms22126259.
    [33]
    ZHOU L Y. Homocysteine and Parkinson ' s disease[J]. CNS Neurosci Ther, 2024, 30(2): e14420. DOI: 10.1111/cns.14420.
    [34]
    ZHOU H R, ZHONG X M, CHEN B, et al. Interactive effects of elevated homocysteine and late-life depression on cognitive impairment[J]. J Affect Disord, 2020, 277(1): 212-217.
    [35]
    MORADI F, LOTFI K, ARMIN M, et al. The association between serum homocysteine and depression: a systematic review and meta-analysis of observational studies[J]. Eur J Clin Invest, 2021, 51(5): e13486. DOI: 10.1111/eci.13486.
    [36]
    BHOME R, ZARKALI A, THOMAS G E C, et al. Thalamic white matter macrostructure and subnuclei volumes in Parkinson ' s disease depression[J]. NPJ Parkinsons Dis, 2022, 8(1): 2. DOI: 10.1038/s41531-021-00270-y.
    [37]
    陈俊虎, 王燕燕, 廖凯举, 等. 流行病学思维方法在全科医生培养中的应用研究[J]. 中华全科医学, 2020, 18(6): 887-889, 975. doi: 10.16766/j.cnki.issn.1674-4152.001384

    CHEN J H, WANG Y Y, LIAO K J, et al. Study on the application of epidemiological thinking and methods in the training of general practitioners[J]. Chinese Journal of General Practice, 2020, 18(6): 887-889, 975. doi: 10.16766/j.cnki.issn.1674-4152.001384
    [38]
    WANG J X, YOU D Y, WANG H P, et al. Association between homocysteine and obesity: a meta-analysis[J]. J Evid Based Med, 2021, 14(3): 208-217.
    [39]
    刘学欣, 霍丽静, 王晓曦, 等. 幽门螺杆菌感染与超重、肥胖的关系[J]. 河北医药, 2023, 45(19): 3000-3003, 3009.

    LIU X X, HUO L J, WANG X X, et al. Correlation of the Helicobacter pylori infection with overweight and obesity and its influencing factors[J]. Hebei Medical Journal, 2023, 45(19): 3000-3003, 3009.
    [40]
    NIU X, CHEN Y Z, ZHONG Y, et al. The relationship between serum homocysteine levels and sudden sensorineural hearing loss: a meta-analysis[J]. Eur Arch Otorhinolaryngol, 2023, 280(5): 2091-2097.
    [41]
    WANG Y J, XIONG W P, SUN X, et al. Characteristics and prognosis analysis of bilateral sudden sensorineural hearing loss: a retrospective case-control study[J]. Clin Otolaryngol, 2022, 47(6): 732-740.
    [42]
    苏军. 后循环缺血患者血脂、血清同型半胱氨酸和糖化血红蛋白水平及与眩晕程度关系分析[J]. 现代实用医学, 2020, 32(8): 999-1000.

    SU J. Analysis of lipids, serum homocysteine and glycosylated hemoglobin levels and their relationship with the degree of vertigo in patients with posterior circulation ischemia[J]. Modern Practical Medicine, 2020, 32(8): 999-1000.
    [43]
    THAKUR P, BHALERAO A. High homocysteine levels during pregnancy and its association with placenta-mediated complications: a scoping review[J]. Cureus, 2023, 15(2): e35244. DOI: 10.7759/cureus.35244.
    [44]
    KUAN V, DENAXAS S, PATALAY P, et al. Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study[J]. Lancet Digit Health, 2023, 5(1): e16-e27. DOI: 10.1016/S2589-7500(22)00187-X.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (15) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return