Volume 23 Issue 3
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WEI Xinyuan, WANG Caizhi, WANG Lingling. Prediction value of Caprini score combined with serology for lower extremity deep vein thrombosis in patients with gynecological malignant tumor[J]. Chinese Journal of General Practice, 2025, 23(3): 379-382. doi: 10.16766/j.cnki.issn.1674-4152.003908
Citation: WEI Xinyuan, WANG Caizhi, WANG Lingling. Prediction value of Caprini score combined with serology for lower extremity deep vein thrombosis in patients with gynecological malignant tumor[J]. Chinese Journal of General Practice, 2025, 23(3): 379-382. doi: 10.16766/j.cnki.issn.1674-4152.003908
shu

Prediction value of Caprini score combined with serology for lower extremity deep vein thrombosis in patients with gynecological malignant tumor

doi: 10.16766/j.cnki.issn.1674-4152.003908

  • Department of Obstetrics and Gynecology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2021A0754

  • Received Date: 2024-01-09
    Available Online: 2025-05-14
    Abstract
  •   Objective  The clinical characteristics and serological indexes of patients with lower extremity deep vein thrombosis (DVT) after surgery for gynecologic malignant tumor are retrospectively analyzed, and the predictive value of Caprini score combined with preoperative D-D and FIB for postoperative DVT in patients with gynecologic malignant tumor is discussed.  Methods  Ninety-five patients with postoperative DVT of lower limbs who were treated in the Department of Gynecology and Gynecologic Oncology of the First Affiliated Hospital of Bengbu Medical University from October 2018 to October 2022 were selected as the thrombus group, and 190 patients who were admitted for surgical treatment during the same period but did not develop DVT were included as the non-thrombotic group at a ratio of 1∶2. The general data of the two groups were compared, and the relationship between Caprini score and preoperative D-D, FIB was analyzed, and the predictive value of the combined application of the three on postoperative DVT of gynecological malignant tumor was discussed.  Results  Postoperative Caprini score was positively correlated with preoperative D-D and FIB in thrombus group (r=0.375, 0.426, both P < 0.05). The AUC of postoperative DVT in patients diagnosed with gynecological malignant tumor by Caprini score, D-D and FIB were 0.832, 0.811 and 0.782, respectively. The optimal critical values were 8.50 points, 0.54 mg/L and 3.26 g/L, respectively. The sensitivity were 62.10%, 76.80% and 69.50%, respectively. The specificity were 90.50%, 74.70% and 77.90%, respectively. The sensitivity and specificity of Caprini score combined with D-D and FIB in the diagnosis of postoperative DVT in patients with gynecological malignant tumor were 78.90%, 79.50% and 0.859 (P < 0.05).  Conclusion  In patients with gynecological malignant tumors, postoperative Caprini score is positively correlated with preoperative D-D and FIB. When postoperative Caprini score is ≥8.50 points, preoperative D-D is ≥0.54 mg/L and preoperative FIB is ≥3.26 g/L, DVT should be highly suspected.

     

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