Volume 23 Issue 3
Mar.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(3): 425-429
SHANG Chuanbo, CHEN Xin, CHEN Jianguo. The value of serum Cys-C, β2MG and SCr in the diagnosis of chronic renal failure complicated with heart failure and their relationship with cardiac function grading[J]. Chinese Journal of General Practice, 2025, 23(3): 425-429. doi: 10.16766/j.cnki.issn.1674-4152.003919
Citation: SHANG Chuanbo, CHEN Xin, CHEN Jianguo. The value of serum Cys-C, β2MG and SCr in the diagnosis of chronic renal failure complicated with heart failure and their relationship with cardiac function grading[J]. Chinese Journal of General Practice, 2025, 23(3): 425-429. doi: 10.16766/j.cnki.issn.1674-4152.003919
shu

The value of serum Cys-C, β2MG and SCr in the diagnosis of chronic renal failure complicated with heart failure and their relationship with cardiac function grading

doi: 10.16766/j.cnki.issn.1674-4152.003919
  • 1.

    Department of Nephrology, Wuhu First People ' s Hospital, Wuhu, Anhui 241000, China

Funds:

 2008085MH257

  • Received Date: 2024-01-06
    Available Online: 2025-05-14
    Abstract
  •   Objective  To analyze the value of serum cystatin C (Cys-C), β2 microglobulin (β2MG) and creatinine (SCr) in the diagnosis of chronic renal failure (CRF) complicated with heart failure, and to analyze their relationship with cardiac function, so as to provide reference for clinical diagnosis of this disease.  Methods  A total of 60 patients with CRF complicated with heart failure admitted to Wuhu First People ' s Hospital from January 2020 to July 2023 were selected as the observation group, another 60 patients with CRF during the same period were selected as the simple CRF group, and 60 healthy subjects during the same period were selected as the control group. Serum levels of Cys-C, β2MG and SCr were compared between the three groups of subjects and those in the observation group with different cardiac function grades. The value of serum Cys-C, β2MG and SCr alone or combined in the diagnosis of CRF complicated with heart failure was analyzed by ROC curve, and the relationship between serum Cys-C, β2MG and SCr and cardiac function grades was analyzed.  Results  The serum levels of Cys-C, β2MG and SCr in observation group were higher than those in simple CRF group and control group, and those in simple CRF group were higher than those in control group (P < 0.05). The levels of Cys-C, β2MG and SCr in grade Ⅳ patients were higher than those in grade Ⅰ, grade Ⅱ and grade Ⅲ patients (P < 0.05). The AUC value of serum Cys-C, β2MG and SCr combined detection in the diagnosis of CRF complicated with heart failure was higher than that of single detection (Z=4.303, 3.843, 5.867, all P < 0.05). Logistic regression analysis showed that serum Cys-C, β2MG and SCr levels were the influencing factors of cardiac function classification in patients with CRF complicated with heart failure (P < 0.05).  Conclusion  Serum Cys-C, β2MG and SCr are the influencing factors of cardiac function classification in patients with CRF complicated with heart failure, and the combined detection of CRF and heart failure has higher diagnostic value.

     

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