Volume 23 Issue 4
Apr.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(4): 570-572
NI Lulu, LI Jiming, YANG Yuying, ZHAO Min, MA Ling, Xiaokelaiti·Huojiahemaiti. Risk factors and prognosis analysis of severe acute pancreatitis complicated with abdominal compartment syndrome[J]. Chinese Journal of General Practice, 2025, 23(4): 570-572. doi: 10.16766/j.cnki.issn.1674-4152.003952
Citation: NI Lulu, LI Jiming, YANG Yuying, ZHAO Min, MA Ling, Xiaokelaiti·Huojiahemaiti. Risk factors and prognosis analysis of severe acute pancreatitis complicated with abdominal compartment syndrome[J]. Chinese Journal of General Practice, 2025, 23(4): 570-572. doi: 10.16766/j.cnki.issn.1674-4152.003952
shu

Risk factors and prognosis analysis of severe acute pancreatitis complicated with abdominal compartment syndrome

doi: 10.16766/j.cnki.issn.1674-4152.003952

  • Emergency Trauma Center Intensive Care Unit, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, China

Funds:

 2022D01C226

 WJWY-202017

  • Received Date: 2024-07-03
    Available Online: 2025-06-30
    Abstract
  •   Objective  Abdominal compartment syndrome is a common and fatal complication in patients with severe acute pancreatitis, which can lead to multiple organ failure and ultimately result in death. Understanding the relevant risk factors is beneficial for early prevention and treatment of abdominal compartment syndrome. The aim of the present study was to explore the risk factors and prognosis of abdominal compartment syndrome in severe acute pancreatitis patients.  Methods  From January 2020 to June 2022, 287 patients with severe acute pancreatitis admitted to the First Affiliated Hospital of Xinjiang Medical University were retrospectively collected. Based on whether the patients developed abdominal compartment syndrome or not, they were divided into the abdominal compartment syndrome group (n=53) and the control group (n=234). The differences in clinical characteristics between the two groups were compared, and multivariate logistic regression analysis was used to explore the risk factors of abdominal compartment syndrome.  Results  Compared with the control group, the proportion of patients with an APPACHE Ⅱ score>10 in the abdominal compartment syndrome group significantly increased [54.72% (29 cases) vs. 39.32% (92 cases), P=0.040]; The proportion of Ranson scores>4 increased [59.62% (31 cases) vs. 42.74% (100 cases), P=0.027]; The proportion of pancreatic necrosis and infection increased [96.23% (51 cases) vs. 77.78% (182 cases), P=0.002]; The proportion of multiple organ failure increased [86.79% (46 cases) vs. 43.16% (101 cases), P < 0.001]; The proportion of abdominal bleeding increased [20.75% (11 cases) vs. 9.40% (22 cases), P=0.019]; The proportion of biliary tract infections increased [15.09% (8 cases) vs. 6.41% (15 cases), P=0.036]. Pancreatic necrosis infection, multiple organ failure, abdominal bleeding, and biliary tract infection were risk factors for abdominal compartment syndrome in severe acute pancreatitis patients (P < 0.05). Abdominal compartment syndrome and biliary tract infection were risk factors for hospital death in patients with severe acute pancreatitis (P < 0.05).  Conclusion  Pancreatic necrosis infection, multiple organ failure, abdominal bleeding, and biliary tract infection are associated with abdominal compartment syndrome, which is an independent risk factor for poor prognosis in patients with severe acute pancreatitis.

     

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    • References(21)
  • [1]
    刘康豪, 戴胜兰. 急性胰腺炎自噬受损与细胞器相互作用的研究进展[J]. 中华实用诊断与治疗杂志, 2024, 38(1): 106-108.
    [2]
    刘幸, 李海雯, 黄红丽, 等. 益生菌强化肠内营养支持对重症急性胰腺炎患者胃肠道功能和炎症因子的影响[J]. 昆明医科大学学报, 2021, 42(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20211116

    LIU X, LI H W, HUANG H L, et al. The effect of probiotics enhanced enteral nutrition support on gastrointestinal function and inflammatory factors in patients with severe acute pancreatitis[J]. Journal of Kunming Medical University, 2021, 42(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20211116
    [3]
    SÁ P, OLIVEIRA-PINTO J, MANSILHA A. Mansilha Abdominal compartment syndrome after r-EVAR: a systematic review with meta-analysis on incidence and mortality[J]. Int Angiol, 2020, 39(5): 411-421. http://www.zhangqiaokeyan.com/journal-foreign-detail/0704028600105.html
    [4]
    JAAN A, SARFRAZ Z, FAROOQ U, et al. Incidence, implications and predictors of abdominal compartment syndrome in acute pancreatitis: a nationwide analysis[J]. Pancreatology, 2024, 24(3): 370-377. doi: 10.1016/j.pan.2024.02.010
    [5]
    JABER S, GARNIER M, ASEHNOUNE K, et al. Guidelines for the management of patients with severe acute pancreatitis, 2021[J]. Anaesth Crit Care Pain Med, 2022, 41(3): 101060-101072. doi: 10.1016/j.accpm.2022.101060
    [6]
    JOHNA S, BOWMAN N, MAC O, et al. The role of the urinary bladder in the diagnosis of abdominal compartment syndrome: a prospective study in trauma patients[J]. Cureus, 2022, 14(4): e24238-e24249.
    [7]
    ZHAO M X, D'ATTELLIS N, EMERSON D, et al. Automated intra-abdominal pressure monitoring during orthotopic heart transplant leads to early diagnosis and treatment of intraoperative abdominal compartment syndrome: a case report[J]. Front Surg, 2022, 9(81): 2288-2299. http://pubmed.ncbi.nlm.nih.gov/35296128/
    [8]
    YAMAZAKI M, NAGAO T, KONO K, et al. Abdominal compartment syndrome secondary to a large retroperitoneal hematoma caused by ruptured gastroduodenal artery pseudoaneurysms in a patient with severe acute pancreatitis[J]. Acute Med Surg, 2023, 10(1): e866-e871. doi: 10.1002/ams2.866
    [9]
    KAWASAKI Y, KAMIDANI R, OKADA H, et al. Midline fasciotomy for severe acute pancreatitis with abdominal compartment syndrome: case report[J]. Ann Med Surg(Lond), 2022, 79(10): 4081-4092.
    [10]
    XU J M, YANG H D, TIAN X P. Effects of early hemofiltration on organ function and intra-abdominal pressure in severe acute pancreatitis patients with abdominal compartment syndrome[J]. Clin Nephrol, 2019, 92(5): 243-249. doi: 10.5414/CN109435
    [11]
    MANIJASHVILI Z, LOMIDZE N, AKHALADZE G, et al. Fasciotomy in the complex treatment of the abdominal compartment syndrome for pancreatic necrosis[J]. Georgian Med News, 2019(286): 40-45.
    [12]
    NASA P, CHANCHALANI G, JUNEJA D, et al. Surgical decompression for the management of abdominal compartment syndrome with severe acute pancreatitis: a narrative review[J]. World J Gastrointest Surg, 2023, 15(9): 1879-1891. doi: 10.4240/wjgs.v15.i9.1879
    [13]
    JENA A, SINGH A, KOCHHAR R. Intra-abdominal hypertension and abdominal compartment syndrome in acute pancreatitis[J]. Indian J Gastroenterol, 2023, 42(4): 455-466. doi: 10.1007/s12664-023-01407-y
    [14]
    HUANG Z, GONG H, TANG C, et al. Remission of organ failure in patients with predicted severe acute pancreatitis treated by somatostation, octreotide and cyclooxygenase-2 inhibitors[J]. Pancreatology, 2024, 24(1): 24-31. doi: 10.1016/j.pan.2023.12.006
    [15]
    宋杰, 银艳桃, 王建超, 等. 血塞通对急性胰腺炎瘀毒互结证患者的炎症、微循环以及肠屏障功能的影响[J]. 中国中医基础医学杂志, 2021, 27(8): 1289-1294.

    SONG J, YIN Y T, WANG J C, et al. Effects of Xuesaitong on inflammation, microcirculation and intestinal barrier function in patients with acute pancreatitis of blood stasis toxin syndrome[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2021, 27(8): 1289-1294.
    [16]
    DE WAELE J. Intra-abdominal hypertension and abdominal compartment syndrome[J]. Curr Opin Crit Care, 2022, 28(6): 695-701. doi: 10.1097/MCC.0000000000000991
    [17]
    LEON M, CHAVEZ L, SURANI S. Abdominal compartment syndrome among surgical patients[J]. World J Gastrointest Surg, 2021, 13(4): 330-339. doi: 10.4240/wjgs.v13.i4.330
    [18]
    程峰, 邱兆磊, 郑传明, 等. JAK/STAT信号通路在大鼠重症急性胰腺炎早期作用机制的研究[J]. 中华全科医学, 2023, 21(1): 41-44, 65. doi: 10.16766/j.cnki.issn.1674-4152.002807

    CHENG F, QIU Z L, ZHENG C M, et al. Study on the mechanism of JAK/STAT signaling pathway in the early stage of severe acute pancreatitis in rats[J]. Chinese Journal of General Practice, 2023, 21(1): 41-44, 65. doi: 10.16766/j.cnki.issn.1674-4152.002807
    [19]
    李磊, 郑传明, 夏群, 等. 肝素结合蛋白联合降钙素原在评估急性胰腺炎合并感染中的预测价值[J]. 中华全科医学, 2020, 18(6): 927-929, 1068. doi: 10.16766/j.cnki.issn.1674-4152.001394

    LI L, ZHENG C M, XIA Q, et al. The predictive value of heparin binding protein combined with procalcitonin in evaluating the co infection of acute pancreatitis[J]. Chinese Journal of General Practice, 2020, 18(6): 927-929, 1068. doi: 10.16766/j.cnki.issn.1674-4152.001394
    [20]
    BROWN J, WARNOCK B, TURK E, et al. Open abdomen during extracorporeal membrane oxygenation is a safe and effective treatment for abdominal compartment syndrome[J]. J Pediatr Surg, 2022, 57(9): 216-222. doi: 10.1016/j.jpedsurg.2021.11.020
    [21]
    樊斌, 李庆贺, 李伟, 等. 血清胆碱酯酶水平联合炎性反应因子对重症急性胰腺炎并发肺部感染的预测价值[J]. 河北医学, 2024, 30(6): 1003-1007. doi: 10.3969/j.issn.1006-6233.2024.06.024

    FAN B, LI Q H, LI W, et al. Predictive value of serum cholinesterase levels combined with inflammatory response factors for pulmonary infection complicating severe acute pancreatitis[J]. Hebei Medicine, 2024, 30(6): 1003-1007. doi: 10.3969/j.issn.1006-6233.2024.06.024
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