Volume 23 Issue 4
Apr.  2025
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PAN Ye, JIN Huawei, GAO Qian. Analyzing the correlation of GLP-1R with blood glucose and lipids and its effect on obese patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(4): 596-599. doi: 10.16766/j.cnki.issn.1674-4152.003959
Citation: PAN Ye, JIN Huawei, GAO Qian. Analyzing the correlation of GLP-1R with blood glucose and lipids and its effect on obese patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(4): 596-599. doi: 10.16766/j.cnki.issn.1674-4152.003959
shu

Analyzing the correlation of GLP-1R with blood glucose and lipids and its effect on obese patients with type 2 diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.003959

  • Department of Endocrinology, Affiliated Hospital of Shaoxing University of Arts and Sciences, Shaoxing, Zhejiang 312000, China

Funds:

 2024KY1739

  • Received Date: 2024-07-25
    Available Online: 2025-06-30
    Abstract
  •   Objective  To analyze the effect of glucagon-like peptide-1 receptor (GLP-1R) gene polymorphisms on obese patients with type 2 diabetes mellitus and investigate the correlation between this receptor and glycemic and lipid indices.  Methods  A total of 80 obese patients with type 2 diabetes mellitus admitted to the Affiliated Hospital of Shaoxing University of Arts and Sciences from January 2022 to November 2023 were selected as the observation group, while 80 cases of healthy individuals were selected as the control group. The glycemic and lipid indices, gene distribution, correlation, and multifactorial logistic analysis were compared between the two groups.  Results  The distribution of total cholesterol, triglycerides, fasting blood glucose, glycosylated hemoglobin levels, rs3765467 locus CC genotype and rs2268657 locus GG genotype were higher in the observation group than those in the control group (P < 0.05). The glycated hemoglobin was significantly higher in patients with CC genotype at rs3765467 locus than CT+TT genotype, and HDL was significantly higher in patients with GG genotype at rs2268657 locus than GA+AA genotype (P < 0.05). The CC gene at locus rs3765467 was positively correlated with glycated hemoglobin (r=0.825, P=0.036), and the GG genotype at locus rs2268657 was positively correlated with HDL (r=0.812, P=0.023). The GLP-1R rs3765467 locus and rs2268657 locus were identified as factors influencing the development of type 2 diabetes mellitus (OR=3.414, 3.206, all P < 0.05).  Conclusion  The CC gene at locus rs3765467 was positively correlated with glycated hemoglobin, while the GG genotype at locus rs2268657 was positively correlated with HDL. The GLP-1R rs3765467 and rs2268657 loci are associated with the development of type 2 diabetes.

     

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    • References(20)
  • [1]
    何博, 陈日超, 易莉娜, 等. 彩色多普勒超声检查参数评估肾动脉血流变化与检测平均血小板体积及血小板分布宽度对早期2型糖尿病肾病的诊断价值[J]. 中国医学装备, 2023, 20(2): 82-87.

    HE B, CHEN R C, YI L N, et al. Diagnostic value of color Doppler ultrasonography parameters for assessing renal artery blood flow changes and detecting mean platelet volume and platelet distribution width in early type 2 diabetic nephropathy[J]. China Medical Equipment, 2023, 20(2): 82-87.
    [2]
    田沫, 岳岩坤, 邓禹, 等. 血糖控制不佳2型糖尿病视网膜病变患者外周血VEGF、HIF-1α和ET-1水平及其临床意义[J]. 中国现代医学杂志, 2020, 30(5): 54-59.

    TIAN M, YUE Y K, DENG Y, et al. Peripheral blood levels of VEGF, HIF-1α and ET-1 in patients with type 2 diabetic retinopathy with poor glycemic control and their clinical significance[J]. Chinese Journal of Modern Medicine, 2020, 30(5): 54-59.
    [3]
    张咪, 梁伟, 许祥. 达格列净和西格列汀治疗超重及肥胖2型糖尿病的疗效及安全性对比[J]. 实用医学杂志, 2021, 37(9): 1182-1186.

    ZHANG M, LIANG W, XU X. Comparison of efficacy and safety of dagliflozin and selegiline in the treatment of overweight and obese type 2 diabetes mellitus[J]. Journal of Practical Medicine, 2021, 37(9): 1182-1186.
    [4]
    卢姗, 李立, 张朝云, 等. GLP-1R rs6923761基因多态性和不同剂量利拉鲁肽对2型糖尿病伴肥胖/超重患者治疗效果和减重的影响[J]. 中南药学, 2021, 19(2): 351-355.

    LU S, LI L, ZHANG C Y, et al. Effects of GLP-1R rs6923761 gene polymorphism and different doses of liraglutide on the therapeutic efficacy and weight loss in type 2 diabetes mellitus with obesity/overweight patients[J]. Zhongnan Pharmacology, 2021, 19(2): 351-355.
    [5]
    房彬彬, 罗俊一, 李艳红, 等. GLP1R基因rs1042044多态性与2型糖尿病的相关性研究[J]. 新疆医科大学学报, 2021, 44(1): 8-11.

    FANG B B, LUO J Y, LI Y H, et al. Correlation between rs1042044 polymorphism of GLP1R gene and type 2 diabetes mellitus[J]. Journal of Xinjiang Medical University, 2021, 44(1): 8-11.
    [6]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)(上)[J]. 中国实用内科杂志, 2021, 41(8): 668-695.

    Chinese Medical Association Diabetes Branch. Guidelines for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition)[J]. Chinese Journal of Practical Internal Medicine, 2021, 41(8): 668-695.
    [7]
    高晶晶, 李聪, 高磊, 等. 早发2型糖尿病骨密度、骨代谢变化及影响因素分析[J]. 中华全科医学, 2023, 21(1): 24-27, 32. doi: 10.16766/j.cnki.issn.1674-4152.002803

    GAO J J, LI C, GAO L, et al. Analysis of changes in bone mineral density and bone metabolism in early-onset type 2 diabetes mellitus and the factors affecting them[J]. Chinese Family Medicine, 2023, 21(1): 24-32. doi: 10.16766/j.cnki.issn.1674-4152.002803
    [8]
    金昕, 侯瑞芳, 陆灏. 胰岛素强化治疗后转换为利拉鲁肽治疗新诊断2型糖尿病合并肥胖1例[J]. 中华糖尿病杂志, 2023, 15(Z1): 189-192.

    JIN X, HOU R F, LU H. A case of newly diagnosed type 2 diabetes mellitus combined with obesity treated with liraglutide after intensive insulin therapy[J]. Chinese Journal of Diabetes, 2023, 15(2): 189-192.
    [9]
    罗琼, 徐文光, 李琴, 等. GLP-1RA、DPP-4抑制剂治疗2型糖尿病肥胖患者的疗效及其对心血管疾病发病风险的对比[J]. 心血管康复医学杂志, 2021, 30(2): 159-164.

    LUO Q, XU W G, LI Q, et al. Comparison of the efficacy of GLP-1RA and DPP-4 inhibitors in the treatment of obese patients with type 2 diabetes mellitus and their risk of cardiovascular disease[J]. Journal of Cardiovascular Rehabilitation Medicine, 2021, 30(2): 159-164.
    [10]
    姜露, 厉平. GLP-1类似物和受体激动剂对2型糖尿病合并肥胖及单纯肥胖患者体重影响的研究进展[J]. 医学综述, 2020, 26(2): 341-345.

    JIANG L, LI P. Research progress on the effects of GLP-1 analogs and receptor agonists on body weight in obese and simple obese patients with type 2 diabetes mellitus[J]. Medical Review, 2020, 26(2): 341-345.
    [11]
    周英旎, 石敏, 赖敬波, 等. 聚乙二醇洛塞那肽联合二甲双胍治疗新诊断肥胖2型糖尿病[J]. 实用医学杂志, 2023, 39(2): 170-174.

    ZHOU Y N, SHI M, LAI J B, et al. Treatment of newly diagnosed obese type 2 diabetes mellitus with polyethylene glycol losenatide combined with metformin[J]. Journal of Practical Medicine, 2023, 39(2): 170-174.
    [12]
    张静静, 祝超瑜, 肖元元, 等. 胰高血糖素样肽1受体基因rs3765467变异与2型糖尿病的关联研究[J]. 上海交通大学学报(医学版), 2021, 41(9): 1215-1221.

    ZHANG J J, ZHU C H, XIAO Y Y, et al. Association between the rs3765467 variant of glucagon-like peptide 1 receptor gene and type 2 diabetes mellitus[J]. Journal of Shanghai Jiao Tong University(Medical Edition), 2021, 41(9): 1215-1221.
    [13]
    罗琼, 徐文光, 李琴, 等. GLP-1RA、DPP-4抑制剂治疗2型糖尿病肥胖患者的疗效及其对心血管疾病发病风险的对比[J]. 心血管康复医学杂志, 2021, 30(2): 159-164.

    LUO Q, XU W G, LI Q, et al. Comparison of the efficacy of GLP-1RA and DPP-4 inhibitors in the treatment of obese patients with type 2 diabetes mellitus and their risk of cardiovascular disease[J]. Journal of Cardiovascular Rehabilitation Medicine, 2021, 30(2): 159-164.
    [14]
    刘东华, 荆凡波, 全香花, 等. 基因多态性与胰高血糖素样肽1受体激动剂疗效的相关性研究进展[J]. 中国药房, 2020, 31(2): 245-250.

    LIU D H, JING F B, QUAN X H, et al. Correlation between gene polymorphisms and efficacy of glucagon-like peptide 1 receptor agonists[J]. Chinese Pharmacy, 2020, 31(2): 245-250.
    [15]
    韩辰宇, 叶晓梅, 张敏. 重组人胰高血糖素样肽-1对2型糖尿病合并肥胖患者脂肪组织功能障碍的影响[J]. 临床内科杂志, 2023, 40(7): 489-490.

    HAN C Y, YE X M, ZHANG M. Effect of recombinant human glucagon-like peptide-1 on adipose tissue dysfunction in obese patients with type 2 diabetes mellitus[J]. Journal of Clinical Internal Medicine, 2023, 40(7): 489-490.
    [16]
    吴丽娜, 秦贵军. SGLT2抑制剂在肥胖2型糖尿病治疗中的价值[J]. 中国实用内科杂志, 2020, 40(8): 638-640.

    WU L N, QIN G J. The value of SGLT2 inhibitors in the treatment of obese type 2 diabetes mellitus[J]. Chinese Journal of Practical Internal Medicine, 2020, 40(8): 638-640.
    [17]
    杨祉妍, 杜悦, 王昕宇, 等. GLP-1受体激动剂治疗2型糖尿病合并肾损伤患者的疗效和安全性: 一项Meta分析[J]. 中国医院药学杂志, 2022, 42(18): 1910-1917.

    YANG Z Y, DU Y, WANG X Y, et al. Efficacy and safety of GLP-1 agonists in the treatment of patients with type 2 diabetes mellitus combined with renal injury: a meta-analysis[J]. Chinese Journal of Hospital Pharmacy, 2022, 42(18): 1910-1917.
    [18]
    刘思琪, 赵一璟, 杨昱, 等. GLP-1受体激动剂对2型糖尿病肥胖患者肌少症影响的研究进展[J]. 东南大学学报(医学版), 2021, 40(4): 552-556.

    LIU S Q, ZHAO Y J, YANG Y, et al. Research progress on the effects of GLP-1 receptor agonists on sarcopenia in obese patients with type 2 diabetes mellitus[J]. Journal of Southeast University(Medical Edition), 2021, 40(4): 552-556.
    [19]
    苗瑞田, 高萍. GLP-1RA对2型糖尿病合并心血管疾病的影响[J]. 心血管康复医学杂志, 2023, 32(1): 99-102.

    MIAO R T, GAO P. Effect of GLP-1RA on cardiovascular disease in type 2 diabetes mellitus[J]. Journal of Cardiovascular Rehabilitation Medicine, 2023, 32(1): 99-102.
    [20]
    闫坤, 原丽敏, 张培育, 等. PPARα激动剂联合GLP-1 RAs对2型糖尿病患者Omentin-1、Asprosin水平的影响[J]. 广东医学, 2022, 43(1): 90-93.

    YAN K, YUAN L M, ZHANG P Y, et al. Effects of PPARα agonists combined with GLP-1 RAs on Omentin-1 and Asprosin levels in patients with type 2 diabetes mellitus[J]. Guangdong Medicine, 2022, 43(1): 90-93.
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