Volume 23 Issue 4
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SHANG Ruimiao, KONG Mingang. Correlation between carotid hypoechoic plaques and recurrent cerebral infarction based on quantitative analysis of contrast-enhanced ultrasound[J]. Chinese Journal of General Practice, 2025, 23(4): 640-642. doi: 10.16766/j.cnki.issn.1674-4152.003969
Citation: SHANG Ruimiao, KONG Mingang. Correlation between carotid hypoechoic plaques and recurrent cerebral infarction based on quantitative analysis of contrast-enhanced ultrasound[J]. Chinese Journal of General Practice, 2025, 23(4): 640-642. doi: 10.16766/j.cnki.issn.1674-4152.003969
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Correlation between carotid hypoechoic plaques and recurrent cerebral infarction based on quantitative analysis of contrast-enhanced ultrasound

doi: 10.16766/j.cnki.issn.1674-4152.003969

  • Department of Ultrasound, Jinhua Municipal Central Hospital (the Affiliated Jinhua Hospital Zhejiang University School of Medicine), Jinhua, Zhejiang 321000, China

Funds:

 2020KY1012

  • Received Date: 2024-04-11
    Available Online: 2025-06-30
    Abstract
  •   Objective  To evaluate the value of quantitative contrast-enhanced ultrasound analysis in predicting recurrence cerebral infarction by assessing carotid hypoechoic plaques.  Methods  A total of 116 patients diagnosed with cerebral infarction for the first time at Jinhua Municipal Central Hospital Affiliated to Zhejiang University School of Medicine from August 2019 to August 2021 were included in the study. All patients underwent quantitative contrast-enhanced ultrasound analysis and were followed up for 1 year. Based on recurrence, they were divided into a recurrence group (n=17) and a non-recurrence group (n=99). The general clinical data and relevant parameters of contrast-enhanced ultrasound time-intensity curve were compared between the two groups. The diagnostic performance of contrast-enhanced ultrasound time-intensity curve parameters in predicting cerebral infarction recurrence was analyzed by ROC curves.  Results  (1) There were no significant differences in gender, the National Institutes of Health stroke scale (NIHSS) score, and stroke between the two groups (P > 0.05). However, the average age of the recurrence group was higher than that of the non-recurrence group (P < 0.05). (2) There were no significant differences in the risk factors of cerebrovascular disease between the two groups (P > 0.05). (3) The enhanced intensity (EI) value, slope, and ratio value of the recurrence group were significantly higher than in the non-recurrence group (P < 0.05). (4) Multifactorial logistic regression analysis revealed that EI value and ratio value were independent risk factors for recurrence of cerebral infarction. (5) The AUC values of EI value and ratio in predicting the recurrence of cerebral infarction were 0.679 and 0.706, respectively (Z=1.051, P=0.318), with a higher AUC observed when both values were combined.  Conclusion  Quantitative contrast-enhanced ultrasound analysis can effectively detect the neovascularization and density, and provide valuable reference value for predicting the recurrence of cerebral infarction.

     

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