The role of the mitochondria-inflammasome pathway in the progression of chronic liver disease

WU Huan; WU Long; ZHANG Baofang

doi:10.16766/j.cnki.issn.1674-4152.003972

Volume 23 Issue 4

Apr. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(4): 651-655

WU Huan, WU Long, ZHANG Baofang. The role of the mitochondria-inflammasome pathway in the progression of chronic liver disease[J]. Chinese Journal of General Practice, 2025, 23(4): 651-655. doi: 10.16766/j.cnki.issn.1674-4152.003972

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WU Huan, WU Long, ZHANG Baofang. The role of the mitochondria-inflammasome pathway in the progression of chronic liver disease[J]. Chinese Journal of General Practice, 2025, 23(4): 651-655. doi: 10.16766/j.cnki.issn.1674-4152.003972

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The role of the mitochondria-inflammasome pathway in the progression of chronic liver disease

doi: 10.16766/j.cnki.issn.1674-4152.003972

WU Huan¹
, WU Long²
, ZHANG Baofang^{1
,
,}

1.
Department of Infectious Diseases, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China

Funds:

gzwkj2024-10

黔科合基础-ZK[2024]一般210

gzwkj2023-042

Received Date: 2024-03-21
Available Online: 2025-06-30

Abstract

Abstract

Chronic liver disease is a serious global health concern, with increasing incidence and mortality rates. Mitochondrial dysfunction and activation of the inflammasome pathway play key roles in the progression of chronic liver disease. As the energy center of cells, mitochondria are involved not only in energy metabolism but also in apoptosis, oxidative stress, and inflammation. The inflammasome, an intracellular multiprotein complex, is essential for the cell' s response to pathogens and cellular stress. Recent studies have increasingly linked mitochondria and inflammasome activation, revealing that mitochondria play an important role in inflammasome activation. Damaged mitochondria release signaling molecules that promote the formation and activation of inflammasome, triggering the release of inflammatory cytokines such as IL-1β, IL-18, and TNF-α. Additionally, mitochondria-related proteins directly participate in the assembly and activation of inflammasome. Current researches have shed light on the relationship between mitochondria and inflammasomes in chronic liver disease. In this review, we aim to elaborate on the structure, activation signal pathways, regulatory mechanisms, and their relationship with chronic liver diseases. These insights may offer new directions and targets for the treatment of chronic liver diseases.
- Mitochondria,
- Inflammasome,
- Chronic liver disease

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References(43)

References

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The role of the mitochondria-inflammasome pathway in the progression of chronic liver disease

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