Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus

ZHAO Qi; ZHU Pinghui; MA Li; LYU Taihong; CHEN Yuru

doi:10.16766/j.cnki.issn.1674-4152.004030

Volume 23 Issue 6

Jun. 2025

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2025 > 23(6): 912-915

ZHAO Qi, ZHU Pinghui, MA Li, LYU Taihong, CHEN Yuru. Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(6): 912-915. doi: 10.16766/j.cnki.issn.1674-4152.004030

Citation:

ZHAO Qi, ZHU Pinghui, MA Li, LYU Taihong, CHEN Yuru. Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(6): 912-915. doi: 10.16766/j.cnki.issn.1674-4152.004030

Citation:

ZHAO Qi, ZHU Pinghui, MA Li, LYU Taihong, CHEN Yuru. Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(6): 912-915. doi: 10.16766/j.cnki.issn.1674-4152.004030

PDF( 406 KB)

Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.004030

ZHAO Qi¹
, ZHU Pinghui²
, MA Li^{1
,
,}
, LYU Taihong¹
, CHEN Yuru¹

1.
Department of General Practice, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Funds:

22QK13

学科带头人-02-09

2021-1-05

Received Date: 2024-11-11
Available Online: 2025-09-04

Abstract

Abstract

Objective In recent years, the relationship between blood lipid level and cognitive impairment has received much attention, but there are few studies on plasma apolipoprotein A1 (APOA1). The objective of this study was to investigate the relationship between APOA1 levels and cognitive function in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 223 T2DM patients admitted to Beijing Tiantan Hospital from October 2023 to March 2024 were enrolled by mini-mental state examination. The patients were divided into mild cognitive impairment (MCI) group (n=81) and normal cognitive (NC) group (n=142) with MMSE. The general condition and blood lipid of the two groups were compared, and analyze the correlation between MCI and plasma APOA1 levels. Results Among 223 T2DM patients, 81 cases were in MCI group, accounting for 36.3%. After adjusting for confounders, plasma APOA1 levels plasma APOA1 levels were an independent risk factor for MCI in T2DM patients (OR=6.359, P=0.022), and this association was more significant in people over 60 years of age after age-stratified studies. In addition, among patients with T2DM, significant differences in plasma APOA1 levels were observed across different MMSE score groups (P < 0.001). Conclusion Plasma APOA1 concentration is associated with MCI in T2DM patients, and comprehensive management measures should be taken to actively control plasma APOA1 level in T2DM patients.
- Type 2 diabetes,
- Mild cognitive impairment,
- Middle and old age,
- Plasma apolipoprotein A1

FullText(HTML)

References(20)

References

[1]	田金洲, 解恒革, 王鲁宁, 等. 中国阿尔茨海默病痴呆诊疗指南(2020年版)[J]. 中华老年医学杂志, 2021, 40(3): 269-283. doi: 10.3760/cma.j.issn.0254-9026.2021.03.001 TIAN J Z, XIE H G, WANG L N, et al. Chinese guideline for the diagnosis and treatment of Alzheimer's disease dementia (2020)[J]. Chinese Journal of Geriatrics, 2021, 40(3): 269-283. doi: 10.3760/cma.j.issn.0254-9026.2021.03.001
[2]	JIA L, DU Y, CHU L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study[J]. Lancet Public Health, 2020, 5(12): e661-e671. doi: 10.1016/S2468-2667(20)30185-7
[3]	王琼, 王国平. 阿尔茨海默病的诊断与治疗[J]. 中华全科医学, 2019, 17(8): 1255-1256. http://www.zhqkyx.net/article/id/18f73bba-8d0a-4fc0-8880-f792d4b6bd77 WANG Q, WANG G P. Diagnosis and treatment of Alzheimer's disease[J]. Chinese Journal of General Practice, 2019, 17(8): 1255-1256. http://www.zhqkyx.net/article/id/18f73bba-8d0a-4fc0-8880-f792d4b6bd77
[4]	ANDERSON N D. State of the science on mild cognitive impairment (MCI)[J]. CNS Spectr, 2019, 24(1): 78-87. doi: 10.1017/S1092852918001347
[5]	JONGSIRIYANYONG S, LIMPAWATTANA P. Mild cognitive impairment in clinical practice: a review article[J]. Am J Alzheimers Dis Other Demen, 2018, 33(8): 500-507. doi: 10.1177/1533317518791401
[6]	QARNI T, SALARDINI A. A multifactor approach to mild cognitive impairment[J]. Semin Neurol, 2019, 39(2): 179-187. doi: 10.1055/s-0039-1678585
[7]	ALI M K, PEARSON-STUTTARD J, SELVIN E, et al. Interpreting global trends in type 2 diabetes complications and mortality[J]. Diabetologial, 2022, 65(1): 3-13. doi: 10.1007/s00125-021-05585-2
[8]	BIESSELS G J, NOBILI F, TEUNISSEN C E, et al. Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective[J]. Lancet Neurol, 2020, 19(8): 699-710. doi: 10.1016/S1474-4422(20)30139-3
[9]	XUE M, XU W, OU Y N, et al. Diabetes mellitus and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 144 prospective studies[J]. Ageing Res Rev, 2019, 55: 100944. DOI: 10.1016/j.arr.2019.100944.
[10]	POWER M C, RAWLINGS A, SHARRETT A R, et al. Association of midlife lipids with 20-year cognitive change: a cohort study[J]. Alzheimers Dement, 2018, 14(2): 167-177. doi: 10.1016/j.jalz.2017.07.757
[11]	MARTENS Y A, ZHAO N, LIU C C, et al. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias[J]. Neuron, 2022, 110(8): 1304-1317. doi: 10.1016/j.neuron.2022.03.004
[12]	中华医学会糖尿病学分会, 朱大龙. 中国2型糖尿病防治指南(2020年版)[J]. 中华内分泌代谢杂志, 2021, 37(4): 311-398. doi: 10.3760/cma.j.cn311282-20210304-00142 Chinese Diabetes Society, ZHU D L. Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition)[J]. Chinese Journal of Endocrinology and Metabolism, 2021, 37(4): 311-398. doi: 10.3760/cma.j.cn311282-20210304-00142
[13]	CORREA Y, RAVEL M, IMBERT M, et al. Lipid exchange of apolipoprotein AI amyloidogenic variants in reconstituted high-density lipoprotein with artificial membranes[J]. Protein Sci, 2024, 33(5): e4987. DOI: 10.1002/pro.4987.
[14]	ENDRES K. Apolipoprotein A1, the neglected relative of Apolipoprotein E and its potential role in Alzheimer's disease[J]. Neural Regen Res, 2021, 16(11): 2141-2148. doi: 10.4103/1673-5374.310669
[15]	PILLAI J A, BENA J, BEKRIS L, et al. Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer's disease[J]. Alzheimers Res Ther, 2023, 15(1): 54. DOI: 10.1186/s13195-023-01203-y.
[16]	DENG X, SAFFARI S E, NG S Y E, et al. Blood lipid biomarkers in early Parkinson's disease and Parkinson's disease with mild cognitive impairment[J]. J Parkinsons Dis, 2022, 12(6): 1937-1943. doi: 10.3233/JPD-213135
[17]	PILLAI J A, MAXWELL S, BENA J, et al. Key inflammatory pathway activations in the MCI stage of Alzheimer's disease[J]. Ann Clin Transl Neurol, 2019, 6(7): 1248-1262. doi: 10.1002/acn3.50827
[18]	TONG J H, GONG S Q, ZHANG Y S, et al. Association of circulating apolipoprotein AI levels in patients with Alzheimer's disease: a systematic review and meta-analysis[J]. Front Aging Neurosci, 2022, 14: 899175. DOI: 10.3389/fnagi.2022.899175.
[19]	GUO Y, LI P, MA X, et al. Association of circulating cholesterol level with cognitive function and mild cognitive impairment in the elderly: a community-based population study[J]. Curr Alzheimer Res, 2020, 17(6): 556-565. doi: 10.2174/1567205017666200810165758
[20]	NORDESTGARRD L T, CHRISTOFFERSEN M, AFZAL S, et al. Triglycerides as a shared risk factor between dementia and atherosclerotic cardiovascular disease: a study of 125 727 individuals[J]. Clin Chem, 2021, 67(1): 245-255. doi: 10.1093/clinchem/hvaa269

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(4)

Get Citation

PDF

XML

Article Metrics

Article views (38) PDF downloads(3)

Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.004030

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Relationship between plasma apolipoprotein A1 level and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.004030

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content