Volume 23 Issue 6
Jun.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(6): 927-929
HAO Cuijun, WANG Rui, HONG Yang, LI Xiaoying, HAN Shaojie, LI Fangjiang. The correlation between serum protein kinase Cε activity, myocardial injury markers and myocardial infarction in patients with acute chest pain[J]. Chinese Journal of General Practice, 2025, 23(6): 927-929. doi: 10.16766/j.cnki.issn.1674-4152.004034
Citation: HAO Cuijun, WANG Rui, HONG Yang, LI Xiaoying, HAN Shaojie, LI Fangjiang. The correlation between serum protein kinase Cε activity, myocardial injury markers and myocardial infarction in patients with acute chest pain[J]. Chinese Journal of General Practice, 2025, 23(6): 927-929. doi: 10.16766/j.cnki.issn.1674-4152.004034
shu

The correlation between serum protein kinase Cε activity, myocardial injury markers and myocardial infarction in patients with acute chest pain

doi: 10.16766/j.cnki.issn.1674-4152.004034
  • 1.

    Department of Cardiovascular Medicine, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China

Funds:

 20242070

 20200509

  • Received Date: 2024-10-16
    Available Online: 2025-09-04
    Abstract
  •   Objective  To explore the correlation between serum protein kinase Cε (PKCε) activity, myocardial injury markers and acute myocardial infarction (AMI) in patients with acute chest pain. The study will provide a reference for the prevention and treatment of AMI in patients with acute chest pain.  Methods  A total of 268 patients with acute chest pain who were admitted to the First Affiliated Hospital of Hebei North University from March 2022 to March 2024 were selected and divided into two groups: the AMI group and the non-AMI group according to the occurrence of AMI. Serum PKCε activity and levels of myocardial injury markers [myoglobin (MB), cardiac troponin Ⅰ (cTnI) and creatine kinase-MB (CK-MB)] were evaluated.  Results  The present study found that the AMI group exhibited a lower level of PKCε [(60.31±11.24) μg/L] in comparison to the control group [(87.25±15.96) μg/L]. Furthermore, the AMI group demonstrated higher levels of Mb, cTnI and CK-MB [(119.85±24.72) μg/L, (1.58±0.30) ng/mL and (33.47±8.19) U/L], with the concentrations of (90.69±18.41) μg/L, (0.91±0.15) ng/mL and (15.36±3.79) U/L being found to be significantly higher (t=16.148, 10.788, 22.494, 22.556, P < 0.05). Spearman correlation analysis demonstrated a negative correlation between PKCε and AMI occurrence in patients with acute chest pain, while Mb, cTnI and CK-MB exhibited a positive correlation with this outcome (r=-0.762, 0.611, 0.841, 0.799, P < 0.05).  Conclusion  Serum PKCε activity and myocardial injury markers have been demonstrated to be closely related to AMI occurrence in patients with acute chest pain, and they which can therefore serve as a means to evaluate AMI occurrence in this patient group to a certain extent.

     

    • FullText(HTML)
  • loading
    • References(21)
  • [1]
    孙维忆, 邢欣, 卞晓华, 等. 急诊科急性心肌梗死患者临床特征分析[J]. 中国临床医生杂志, 2023, 51(5): 577-581.

    SUN W Y, XING X, BIAN X H, et al. Analysis of clinical characteristics of acute myocardial infarction patients in emergency department[J]. Chin J Clin, 2023, 51(5): 577-581.
    [2]
    唐骁, 张玉婷, 王志禄. 急性心肌梗死早期诊断的生物标志物研究进展[J]. 医学综述, 2023, 29(5): 877-881.

    TANG X, ZHANG Y T, WANG Z L. Advances in biomarkers for early diagnosis of acute myocardial infarction[J]. Med Recapitul, 2023, 29(5): 877-881.
    [3]
    POZZI G, PRESTA V, MASSELLI E, et al. Interplay between protein kinase c epsilon and reactive oxygen species during myogenic differentiation[J]. Cells, 2023, 12(13): 1792. DOI: 10.3390/cells12131792.
    [4]
    郑曦, 陈世蓉, 熊挺淋, 等. 乌头提取物通过调控蛋白激酶C信号通路对心力衰竭大鼠钙转运及心肌线粒体呼吸功能的影响[J]. 世界中西医结合杂志, 2023, 18(1): 62-67.

    ZHENG X, CHEN S R, XIONG T L, et al. Effects of aconitum carmichaelii extract on calcium transport and myocardial mi-tochondrial respiratory function in rats with heart failure by regulating PKC sig-naling pathway[J]. World J Integr Tradit West Med, 2023, 18(1): 62-67.
    [5]
    THYGESEN K, ALPERT J S, JAFFE A S, et al. Fourth universal definition of myocardial infarction (2018)[J]. Glob Heart, 2018, 13(4): 305-338. doi: 10.1016/j.gheart.2018.08.004
    [6]
    何文君, 张小芳, 金瑜, 等. 胸痛中心建设持续改进对急性ST段抬高型心肌梗死抢救时间及心血管不良事件的影响[J]. 中华全科医学, 2022, 20(9): 1603-1607. doi: 10.16766/j.cnki.issn.1674-4152.002659

    HE W J, ZHANG X F, JIN Y, et al. Impact of continuous improvement in the construction of the chest-pain centre on the rescue time of acute ST segment elevated myocardial infarction and cardiovascular adverse events[J]. Chin J Gen Pract, 2022, 20(9): 1603-1607. doi: 10.16766/j.cnki.issn.1674-4152.002659
    [7]
    孔璨, 彭辉. 沙库巴曲缬沙坦对急性ST段抬高型心肌梗死合并HFpEF患者的疗效[J]. 新医学, 2023, 54(6): 426-431.

    KONG C, PENG H. Clinical efficacy of sacubitril/valsartan in treatment of acute STEMI complicated with HFpEF[J]. New Med, 2023, 54(6): 426-431.
    [8]
    谢振林, 冯雅建, 范志伟, 等. 心锚重复蛋白、肌红蛋白、α1-微球蛋白在急性心肌梗死中的临床意义[J]. 心脑血管病防治, 2023, 23(3): 47-49, 60.

    XIE Z L, FENG Y J, FAN Z W, et al. Clinical significance of anchor-repeat protein, myoglobin and α1-microglobulin in acute myocardial infarction[J]. Prev Treat Cardio-Cerebr-Vasc Dis, 2023, 23(3): 47-49, 60.
    [9]
    吴晓, 王苏英, 李珊. 联合检测NLR、hs-CRP、cTnI、MYO和BNP在急性心肌梗死中的早期诊断价值[J]. 中国急救复苏与灾害医学杂志, 2022, 17(5): 647-650.

    WU X, WANG S Y, LI S. Early diagnostic value of combined detection of NLR, hs-CRP, cTnI, MYO and BNP in acute myocardial infarction[J]. Chin J Emerg Resusc Disas Med, 2022, 17(5): 647-650.
    [10]
    张林敏, 张凯楠, 伏建峰. 神经诱导损伤蛋白1联合CK-MB检测在急性心肌梗死中的诊断价值[J]. 检验医学与临床, 2023, 20(20): 2969-2972, 2977.

    ZHANG L M, ZHANG K N, FU J F. Clinical diagnostic value of nerve-induced injury protein 1 combined with CK-MB detection in acute myocardial infarction[J]. Lab Med Clin, 2023, 20(20): 2969-2972, 2977.
    [11]
    杜宣莉, 牛帅, 吴广福, 等. 床边即时检测技术检测cTnI联合CK-MB、Mb对急性心肌梗死的早期诊断效能分析[J]. 中国急救复苏与灾害医学杂志, 2022, 17(7): 853-855, 868.

    DU X L, NIU S, WU G F, et al. Analysis of the early diagnosis efficacy of cTnI combined with CK-MB and Mb by POCT for patients with acute myocardial infarction[J]. Chin J Emerg Resusc Disas Med, 2022, 17(7): 853-855, 868.
    [12]
    张义龙, 李保军, 靳波, 等. 院外急救中即时检测CK-MB、cTnI和Myo对心肌梗死的早期预测价值临床研究[J]. 中国急救复苏与灾害医学杂志, 2022, 17(9): 1155-1159.

    ZHANG Y L, LI B J, JIN B, et al. Predictive value of point-of-care testing of CK-MB, cTnI, and Myo for acute myocardial infarction in emergency treatment[J]. Chin J Emerg Resusc Disas Med, 2022, 17(9): 1155-1159.
    [13]
    范继红, 刘江红, 王刚, 等. 肌钙蛋白峰值超过检测上限在急性心肌梗死中的临床意义及其早期预测指标[J]. 中国心血管病研究, 2023, 21(8): 673-679.

    FAN J H, LIU J H, WANG G, et al. Clinical significance and early predictive indicators of peak troponin levels exceeding the upper detection limit in acute myocardial infarction (AMI)[J]. Chin J Cardiovasc Res, 2023, 21(8): 673-679.
    [14]
    沈红良, 杨斌, 王星, 等. CK-MBmass, hs-cTnT及CK-MB与急性心肌梗死的相关性及其联合诊断价值[J]. 现代生物医学进展, 2022, 22(11): 2100-2104.

    SHEN H L, YANG B, WANG X, et al. Correlation of CK-MBmass, hs-cTnT and CK-MB with acute myocardial infarction and their combined diagnostic value[J]. Prog Mod Biomed, 2022, 22(11): 2100-2104.
    [15]
    贾寒, 饶慧瑛. 蛋白激酶Cε在非酒精性脂肪性肝病与胰岛素抵抗关系中的作用[J]. 肝脏, 2020, 25(6): 567-568.

    JIA H, RAO H Y. The role of protein kinase Cε in the relationship between non-alcoholic fatty liver disease and insulin resistance[J]. Chin Hepatol, 2020, 25(6): 567-568.
    [16]
    LAI X J, LIANG Y L, JIN J, et al. Protein Kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2[J]. Exp Cell Res, 2023, 422(1): 113427. DOI: 10.1016/j.yexcr.2022.113427.
    [17]
    杨晓林, 齐琦. 蛋白激酶C在运动预适应诱导的心肌保护效应中的作用机制[J]. 基因组学与应用生物学, 2020, 39(6): 2741-2747.

    YANG X L, QI Q. Mechanism of protein kinase C in myocardial protection induced by exercise preconditioning[J]. Genom Appl Biol, 2020, 39(6): 2741-2747.
    [18]
    LA COGNATA V, D'AMICO A G, MAUGERI G, et al. The ε-isozyme of protein kinase C (PKCε) is impaired in ALS motor cortex and its pulse activation by bryostatin-1 produces long term survival in degenerating SOD1-G93A motor neuron-like cells[J]. Int J Mol Sci, 2023, 24(16): 12825. DOI: 10.3390/ijms241612825.
    [19]
    KEBBE M, NAUD P, ASSOUS I, et al. Distinct protein Kinase C isoforms drive the cell cycle re-entry of two separate populations of neonatal rat ventricular cardiomyocytes[J]. Am J Physiol Cell Physiol, 2023, 325(2): C406-C419.
    [20]
    WANG Y, MORISHIMA M, ONO K. Protein Kinase C regulates expression and function of the Cav3.2 T-Type Ca2+ channel during maturation of neonatal rat cardiomyocyte[J]. Membranes (Basel), 2022, 12(7): 686. DOI: 10.3390/membranes12070686.
    [21]
    SOPHOCLEOUS G, OWEN D, MOTT H R. The structure and function of protein Kinase C-related kinases (PRKs)[J]. Biochem Soc Trans, 2021, 49(1): 217-235.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (12) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return