Volume 23 Issue 6
Jun.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(6): 950-953
GU Fangfang, PAN Yongkang, LU Kongjie, ZHU Yingwei, DENG Lang. Effect of sacubitril valsartan on preventing ventricular remodeling after radiofrequency ablation for atrial fibrillation and its influence on inflammatory factors[J]. Chinese Journal of General Practice, 2025, 23(6): 950-953. doi: 10.16766/j.cnki.issn.1674-4152.004040
Citation: GU Fangfang, PAN Yongkang, LU Kongjie, ZHU Yingwei, DENG Lang. Effect of sacubitril valsartan on preventing ventricular remodeling after radiofrequency ablation for atrial fibrillation and its influence on inflammatory factors[J]. Chinese Journal of General Practice, 2025, 23(6): 950-953. doi: 10.16766/j.cnki.issn.1674-4152.004040
shu

Effect of sacubitril valsartan on preventing ventricular remodeling after radiofrequency ablation for atrial fibrillation and its influence on inflammatory factors

doi: 10.16766/j.cnki.issn.1674-4152.004040

  • Department of Cardiovascular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2023KY316

  • Received Date: 2024-12-20
    Available Online: 2025-09-04
    Abstract
  •   Objective  To investigate the effect of sacubitril valsartan on the prediction of ventricular remodeling after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) and analyze its influence on inflammatory factors, with a view to providing a new strategy for clinical treatment.  Methods  A total of 152 AF patients in Huzhou Central Hospital from January 2022 to October 2023 were selected and received RFCA. After surgery, according to the random envelope method, patients were divided into a conventional group (receiving conventional postoperative treatment) and a treatment group (sacubitril valsartan in addition to the conventional group), with 76 cases in each group. The indicators of ventricular remodeling, inflammatory factors, recurrence of atrial fibrillation, and adverse reactions before and after treatment were compared between the two groups.  Results  After 60 days of treatment, the left ventricular ejection fraction and QRS voltage of patients in the treatment group were higher than those in the conventional group (P < 0.05), while the left ventricular end-diastolic diameter, end-systolic diameter, interventricular wall thickness, P wave dispersion and QRS duration were lower than those in the conventional group (P < 0.05). After 60 days of treatment, the levels of serum C-reactive protein and interleukin-6 in the treatment group with (5.33±1.27) mg/L and (5.44±1.15) pg/mL were lower than (6.38±1.18) mg/L and (7.08±1.44) pg/mL in the conventional group (F=28.281, 61.441, both P < 0.05). No statistical differences were observed in the cumulative recurrence rates of atrial fibrillation at 3, 6, and 12 months after treatment between the two groups (P>0.05). There were no statistical differences in the adverse drug reactions between the two groups (P>0.05).  Conclusion  Sacubitril valsartan can effectively improve ventricular remodeling and reduce the inflammatory response in AF patients after RFCA, and it has high safety.

     

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