The relationship of TCM syndrome types with ultrasound hemodynamic and serological indicators in patients with fatty liver

CHEN Yuxiang; YU Haitao; LIU Juan; LI Linjian; YANG Zhifang; XU Jing

doi:10.16766/j.cnki.issn.1674-4152.004054

Volume 23 Issue 6

Jun. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(6): 1008-1012

CHEN Yuxiang, YU Haitao, LIU Juan, LI Linjian, YANG Zhifang, XU Jing. The relationship of TCM syndrome types with ultrasound hemodynamic and serological indicators in patients with fatty liver[J]. Chinese Journal of General Practice, 2025, 23(6): 1008-1012. doi: 10.16766/j.cnki.issn.1674-4152.004054

Citation:

CHEN Yuxiang, YU Haitao, LIU Juan, LI Linjian, YANG Zhifang, XU Jing. The relationship of TCM syndrome types with ultrasound hemodynamic and serological indicators in patients with fatty liver[J]. Chinese Journal of General Practice, 2025, 23(6): 1008-1012. doi: 10.16766/j.cnki.issn.1674-4152.004054

Citation:

CHEN Yuxiang, YU Haitao, LIU Juan, LI Linjian, YANG Zhifang, XU Jing. The relationship of TCM syndrome types with ultrasound hemodynamic and serological indicators in patients with fatty liver[J]. Chinese Journal of General Practice, 2025, 23(6): 1008-1012. doi: 10.16766/j.cnki.issn.1674-4152.004054

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The relationship of TCM syndrome types with ultrasound hemodynamic and serological indicators in patients with fatty liver

doi: 10.16766/j.cnki.issn.1674-4152.004054

CHEN Yuxiang¹
, YU Haitao^{1
,
,}
, LIU Juan²
, LI Linjian³
, YANG Zhifang³
, XU Jing⁴

1.
Department of Ultrasound Medicine, Zhangjiakou First Hospital, Zhangjiakou, Hebei 075000, China

Funds:

2024418

Received Date: 2024-09-06
Available Online: 2025-09-04

Abstract

Abstract

Objective To investigate the correlation among the distribution of traditional Chinese medicine (TCM) syndromes, color Doppler ultrasound hemodynamic changes and serological indexes in patients with fatty liver. Methods A total of 191 patients with fatty liver disease admitted to Zhangjiakou First Hospital from October 2022 to October 2023 were selected as the study objects. According to TCM syndrome differentiation, the patients were divided into group A (syndrome of liver-qi stagnation, n=41), group B (syndrome of liver-Qi and spleen deficiency, n=32), group C (syndrome of phlegm and dampness internal obstruction, n=51), group D (syndrome of dampness-heat accumulation, n=45), and group E (syndrome of phlegm and blood stasis interassociation, n=22). Another 50 healthy examinee were selected as the control group during the same period and were all given Doppler ultrasound examination. Serological indexes were detected. Results There were statistically significant differences in mean portal vein velocity (MPVV), peak portal vein velocity (PPVV), hepatic artery resistive index (HARI), serum ferritin (SF), homocysteine (Hcy) and hypersensitive C-reactive protein (hs-CRP) levels among all groups (P < 0.05). Compared with groups A and B, the levels of MPVV, PPVV and HARI in groups C, D and E showed a gradually decreasing trend (P < 0.05), while the levels of SF, Hcy and hs-CRP showed a gradually increasing trend (P < 0.05). With the aggravation of the severity of fatty liver, the levels of MPVV, PPVV and HARI were gradually decreased (P < 0.05), while the levels of SF, Hcy and hs-CRP were gradually increased (P < 0.05). MPVV, PPVV and HARI showed high sensitivity and specificity in determining phlegm stasis interjunction (P < 0.05). MPVV, PPVV, HARI were negatively correlated with the severity of fatty liver (r=-0.459, -0.436, -0.441, all P < 0.05). The sensitivity and specificity of MPVV, PPVV and HARI in determining severe fatty liver were higher (P < 0.05). Conclusion With the progression of fatty liver disease, MPVV, PPVV and HARI in patients decreases, and the levels of SF, Hcy and hs-CRP in the body gradually increases, and the changes are most obvious in patients with turbid phlegm and blood stasis.
- Fatty liver,
- Types of traditional Chinese medicine syndrome,
- Hemodynamics,
- Serological index,
- Correlation

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References(15)

References

[1]	李茜, 杨洋俊, 孙易, 等. 运动促进肝脏健康: 表观遗传视域下非酒精性脂肪肝病的转归[J]. 中国体育科技, 2024, 60(2): 28-36. LI Q, YANG Y J, SUN Y, et al. Exercise promotes liver health: outcome of nonalcoholic fatty liver disease from an epigenetic perspective[J]. Chin Sport Sci Technol, 2024, 60(2): 28-36.
[2]	KAZANKOV K, JØRGENSEN S M D, THOMSEN K L, et al. The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[J]. Nat Rev Gastroenterol Hepatol, 2019, 16(3): 145-159. doi: 10.1038/s41575-018-0082-x
[3]	TARGHER G, TILG H, BYRNE C D. Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach[J]. Lancet Gastroenterol Hepatol, 2021, 6(7): 578-588. doi: 10.1016/S2468-1253(21)00020-0
[4]	贾绘, 倪薇, 包成明, 等. CT和彩色多普勒超声对急性胰腺炎合并脂肪肝的临床诊断价值[J]. 中华消化病与影像杂志(电子版), 2024, 14(3): 239-243. JIA H, NI W, BAO C M, et al. Clinical diagnostic value of CT and color Doppler ultrasound in acute pancreatitis complicated with fatty liver[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(3): 239-243.
[5]	徐祥涛, 史会连, 陈冉, 等. 基于肝脏磁共振质子密度脂肪分数研究非酒精性脂肪肝病患者中医证候分布及临床特征[J]. 中西医结合肝病杂志, 2023, 33(9): 790-794. XU X T, SHI H L, CHEN R, et al. The distribution of TCM syndromes and the clinical characteristics of nonalcoholic fatty Liver disease on the base of magnetic resonance imaging proton density fat fraction[J]. Chin J Integr Tradit West Med Liver Dis, 2023, 33(9): 790-794.
[6]	曹宇萌, 张海燕, 刘立新. 非酒精性脂肪性肝病的病理改变与血清铁蛋白和血清铁含量变化关系的meta分析[J]. 临床荟萃, 2023, 38(3): 197-207. doi: 10.3969/j.issn.1004-583X.2023.03.001 CAO Y M, ZHANG H Y, LIU L X. Correlation between pathological changes and serum ferritin and iron levels in nonalcoholic fatty liver disease: a meta-analysis[J]. Clin Focus, 2023, 38(3): 197-207. doi: 10.3969/j.issn.1004-583X.2023.03.001
[7]	李潇萌, 吴少玉, 王媛媛. 非酒精性脂肪性肝病合并2型糖尿病患者血清同型半胱氨酸、成纤维细胞生长因子21和核因子-κB水平变化及其临床意义探讨[J]. 实用肝脏病杂志, 2023, 26(2): 202-205. doi: 10.3969/j.issn.1672-5069.2023.02.013 LI X M, WU S Y, WANG Y Y. Implication of serum homocystein, fibroblast growth factor-21 and nuclear factor-κB levels in patients with non-alcoholic fatty liver diseases and T2DM[J]. J Pract Hepatol, 2023, 26(2): 202-205. doi: 10.3969/j.issn.1672-5069.2023.02.013
[8]	周国艳, 李青, 瞿子春, 等. 二甲双胍对2型糖尿病合并非酒精性脂肪肝患者血清FGF21、Hs-CRP的影响[J]. 湖南师范大学学报(医学版), 2022, 19(2): 59-63. doi: 10.3969/j.issn.1673-016X.2022.02.016 ZHOU G Y, LI Q, QU Z C, et al. Effect of metformin on serum FGF21 and Hs-CRP in patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease[J]. J Hunan Normal Univ(Med Sci), 2022, 19(2): 59-63. doi: 10.3969/j.issn.1673-016X.2022.02.016
[9]	中国中西医结合学会消化系统疾病专业委员会. 非酒精性脂肪性肝病中西医结合诊疗共识意见(2017年)[J]. 中国中西医结合消化杂志, 2017, 25(11): 805-811. Digestive Diseases Professional Committee of Chinese Association of Integrated Traditional and Western Medicine. Consensus opinions on the diagnosis and treatment of non-alcoholic fatty liver disease with integrated chinese and western medicine (2017)[J]. Chin J Integr Tradit West Med Diges, 2017, 25(11): 805-811.
[10]	林颖鑫, 孟健, 冯蕾, 等. 声衰减成像在代谢相关脂肪性肝病分级诊断中的应用[J]. 中国医学影像学杂志, 2023, 31(10): 1080-1084, 1102. doi: 10.3969/j.issn.1005-5185.2023.10.015 LIN Y X, MENG J, FENG L, et al. Attenuation imaging in the grading diagnosis of metabolic dyfunction-associated fatty liver disease[J]. Chin J Med Imaging, 2023, 31(10): 1080-1084, 1102. doi: 10.3969/j.issn.1005-5185.2023.10.015
[11]	李新, 李瀛, 蒋春梅, 等. 非酒精性脂肪肝脂肪分数与门脉血流动力学的MRI研究[J]. 中国医学计算机成像杂志, 2022, 28(2): 142-146. doi: 10.3969/j.issn.1006-5741.2022.02.007 LI X, LI Y, JIANG C M, et al. Study on fat fraction and hemodynamics of nonalcoholic fatty liver[J]. Chin Comput Med Imaging, 2022, 28(2): 142-146. doi: 10.3969/j.issn.1006-5741.2022.02.007
[12]	陈长喜, 杜娟, 宋健, 等. 血清超敏C反应蛋白与老年人非酒精性脂肪肝的相关性[J]. 中华全科医学, 2023, 21(9): 1491-1494. doi: 10.16766/j.cnki.issn.1674-4152.003153 CHEN C X, DU J, SONG J, et al. Study on correlation between serum hypersensitive C-reactive protein and nonalcoholic fatty liver disease in the elderly[J]. Chin J Gen Pract, 2023, 21(9): 1491-1494. doi: 10.16766/j.cnki.issn.1674-4152.003153
[13]	韩艳, 张凡, 毛永华, 等. 非酒精性脂肪肝患者血清铁蛋白水平与肝脏硬度的关系[J]. 医学研究杂志, 2021, 50(7): 130-135. HAN Y, ZHANG F, MAO Y H, et al. Relationship between serum ferritin level and liver stiffness among patients with nonalcoholic fatty liver disease[J]. J Med Res, 2021, 50(7): 130-135.
[14]	张瑶, 霍迎新, 赵伟, 等. H型高血压患者血尿酸水平与非酒精性脂肪性肝病的关系[J]. 实用医学杂志, 2024, 40(18): 2561-2565. doi: 10.3969/j.issn.1006-5725.2024.18.009 ZHANG Y, HUO Y X, ZHAO W, et al. The relationship between blood uric acid levels and non-alcoholic fatty liver disease in patients with type H hypertension[J]. J Pract Med, 2024, 40(18): 2561-2565. doi: 10.3969/j.issn.1006-5725.2024.18.009
[15]	POUWELS S, SAKRAN N, GRAHAM Y, et al. Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss[J]. BMC Endocr Disord, 2022, 22(1): 63. DOI: 10.1186/s12902-022-00980-1.

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The relationship of TCM syndrome types with ultrasound hemodynamic and serological indicators in patients with fatty liver

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