Analysis of clinical features and prognostic factors of amyloidosis

ZHANG Shangyi; ZHANG Qike; WEI Xiaofang; FENG Youfan; FU Yuan; CHEN Qiaolin; ZHANG Yuanyuan; ZHANG Shaohua; LIU Jie; LI Chenyang

doi:10.16766/j.cnki.issn.1674-4152.004074

Volume 23 Issue 7

Jul. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(7): 1103-1106

ZHANG Shangyi, ZHANG Qike, WEI Xiaofang, FENG Youfan, FU Yuan, CHEN Qiaolin, ZHANG Yuanyuan, ZHANG Shaohua, LIU Jie, LI Chenyang. Analysis of clinical features and prognostic factors of amyloidosis[J]. Chinese Journal of General Practice, 2025, 23(7): 1103-1106. doi: 10.16766/j.cnki.issn.1674-4152.004074

Citation:

ZHANG Shangyi, ZHANG Qike, WEI Xiaofang, FENG Youfan, FU Yuan, CHEN Qiaolin, ZHANG Yuanyuan, ZHANG Shaohua, LIU Jie, LI Chenyang. Analysis of clinical features and prognostic factors of amyloidosis[J]. Chinese Journal of General Practice, 2025, 23(7): 1103-1106. doi: 10.16766/j.cnki.issn.1674-4152.004074

Citation:

ZHANG Shangyi, ZHANG Qike, WEI Xiaofang, FENG Youfan, FU Yuan, CHEN Qiaolin, ZHANG Yuanyuan, ZHANG Shaohua, LIU Jie, LI Chenyang. Analysis of clinical features and prognostic factors of amyloidosis[J]. Chinese Journal of General Practice, 2025, 23(7): 1103-1106. doi: 10.16766/j.cnki.issn.1674-4152.004074

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Analysis of clinical features and prognostic factors of amyloidosis

doi: 10.16766/j.cnki.issn.1674-4152.004074

1.
The First Clinical Medical College of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China

Funds:

22JR5RA660

25JRRA295

Received Date: 2024-09-24
Available Online: 2025-10-25

Abstract

Abstract

Objective The clinical manifestations of patients with amyloidosis often lack specificity and are often accompanied by multi-organ impairment, resulting in poor prognosis. Therefore, the purpose of this study was to analyze the laboratory and imaging characteristics of patients with amyloidosis and to explore the factors affecting the prognosis of these patients. Methods The clinical data of 41 patients with amyloidosis admitted to Gansu Provincial People' s Hospital from July 2017 to August 2023 were collected, and their clinical characteristics and prognosis were retrospectively analyzed and summarized. Results The median age of onset of 41 patients was 64 (41-75) years. There were 27 males (65.85%) and 14 females (34.15%). Twenty-eight patients (68.29%) received chemotherapy; 6 patients (14.63%) underwent autologous hematopoietic stem cell transplantation (ASCT). Thirteen (31.71%) patients were untreated; Efficacy was evaluated in 28 patients who received treatment, 5 (17.86%) patients had CR, 7 (25.00%) patients had PR, 1 (3.57%) had SD, 1 (3.57%) patients had PD, 7 (25.00%) patients were lost to follow-up, and 7 (25.00%) patients died. Whether there was cardiac involvement, renal involvement, and whether transplantation was performed were risk factors affecting the overall survival of patients (P < 0.05), among which cardiac and renal involvement were independent risk factors affecting the overall survival of patients. Median follow-up was 8 (1-68) months, and median PFS was 6 (1-68) months. Conclusion Amyloidosis is mainly treated with light chain amyloidosis, and the treatment is mainly combined with chemotherapy, patient prognosis is associated with age, cardiac involvement, and renal involvement. ASCT is still the first choice for transplant-eligible patients.
- Amyloidosis,
- Light chain amyloidosis,
- Clinical features,
- Prognosis

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Analysis of clinical features and prognostic factors of amyloidosis

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