Construction and verification of prediction model and treatment strategy for shunt loss after portal hypertension TIPS

QIAN Jinyu; YANG Peipei; ZHANG Yang; XIE Bo; WU Di; TANG Xiaoyun; ZHANG Leiming; TAN Yulin; ZHANG Zichen

doi:10.16766/j.cnki.issn.1674-4152.004075

Volume 23 Issue 7

Jul. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(7): 1107-1110

QIAN Jinyu, YANG Peipei, ZHANG Yang, XIE Bo, WU Di, TANG Xiaoyun, ZHANG Leiming, TAN Yulin, ZHANG Zichen. Construction and verification of prediction model and treatment strategy for shunt loss after portal hypertension TIPS[J]. Chinese Journal of General Practice, 2025, 23(7): 1107-1110. doi: 10.16766/j.cnki.issn.1674-4152.004075

Citation:

QIAN Jinyu, YANG Peipei, ZHANG Yang, XIE Bo, WU Di, TANG Xiaoyun, ZHANG Leiming, TAN Yulin, ZHANG Zichen. Construction and verification of prediction model and treatment strategy for shunt loss after portal hypertension TIPS[J]. Chinese Journal of General Practice, 2025, 23(7): 1107-1110. doi: 10.16766/j.cnki.issn.1674-4152.004075

Citation:

QIAN Jinyu, YANG Peipei, ZHANG Yang, XIE Bo, WU Di, TANG Xiaoyun, ZHANG Leiming, TAN Yulin, ZHANG Zichen. Construction and verification of prediction model and treatment strategy for shunt loss after portal hypertension TIPS[J]. Chinese Journal of General Practice, 2025, 23(7): 1107-1110. doi: 10.16766/j.cnki.issn.1674-4152.004075

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Construction and verification of prediction model and treatment strategy for shunt loss after portal hypertension TIPS

doi: 10.16766/j.cnki.issn.1674-4152.004075

1.
Department of Intervention, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

2021jyxm0956

KJ2021A0804

AHWJ2023BAc10022

Received Date: 2025-03-16
Available Online: 2025-10-25

Abstract

Abstract

Objective To identify the risk factors of shunt dysfunction after transjugular intrahepatic portosystemic shunt (TIPS) in patients with portal hypertension, to construct and verify the clinical prediction model, and to formulate corresponding countermeasures for different types of shunt dysfunction, so as to provide reasonable treatment for patients. Methods The clinical data of 120 patients who underwent TIPS in the interventional department of the First Affiliated Hospital of Bengbu Medical University from January 2020 to December 2024 were retrospectively analyzed. Subsequent to the surgical procedure, the subjects were categorized into two distinct groups, namely the shunt dysfunction group and the non-dysfunction group, with the respective numbers amounting to 35 and 85 cases. Variables with significant differences were included in multivariate logistic regression analysis to determine the independent risk factors, and a prediction model was constructed based on this. The discrimination capacity of the model was evaluated by means of the ROC curve. Finally, the corresponding countermeasures are proposed for the various types of shunt failure. Results Multivariate logistic regression analysis demonstrated that anticoagulation therapy (OR=15.754, P=0.030), portal vein thrombosis (OR=0.052, P=0.008) and portal vein puncture site (OR=0.064, P=0.007) were independent influencing factors for shunt dysfunction after TIPS. The area under the ROC curve (95% CI) of the constructed model was 0.933 (0.882-0.983), and the corresponding optimal cut-off value was 0.866. The sensitivity was 0.894, and the specificity was 0.971. Conclusion Therapy, portal vein thrombosis and portal vein puncture site are independent influencing factors of shunt dysfunction after TIPS. The prediction model constructed accordingly has the potential to assist clinicians in the early identification of risks and the implementation of intervention measures.
- Portal hypertension,
- Transjugular intrahepatic portosystemic shunt,
- Stent dysfunction,
- Risk factors,
- Model development and validation

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References(21)

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