Correlation between cognitive impairment and metabolic level in patients with amyotrophic lateral sclerosis

DOU Ruixia; GU Cheng; ZHANG Lulu; LIANG Yunhua; ZHANG Yi

doi:10.16766/j.cnki.issn.1674-4152.004078

Volume 23 Issue 7

Jul. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(7): 1119-1122

DOU Ruixia, GU Cheng, ZHANG Lulu, LIANG Yunhua, ZHANG Yi. Correlation between cognitive impairment and metabolic level in patients with amyotrophic lateral sclerosis[J]. Chinese Journal of General Practice, 2025, 23(7): 1119-1122. doi: 10.16766/j.cnki.issn.1674-4152.004078

Citation:

DOU Ruixia, GU Cheng, ZHANG Lulu, LIANG Yunhua, ZHANG Yi. Correlation between cognitive impairment and metabolic level in patients with amyotrophic lateral sclerosis[J]. Chinese Journal of General Practice, 2025, 23(7): 1119-1122. doi: 10.16766/j.cnki.issn.1674-4152.004078

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Correlation between cognitive impairment and metabolic level in patients with amyotrophic lateral sclerosis

doi: 10.16766/j.cnki.issn.1674-4152.004078

DOU Ruixia^{1, 2}
, GU Cheng²
, ZHANG Lulu^{1, 2}
, LIANG Yunhua^{1, 2}
, ZHANG Yi^{2
,
,}

1.
Department of Neurology, Gansu Provincial People' s Hospital, Lanzhou, Gansu 730000, China

Funds:

2021ZD0201801

23JRRA1290

Received Date: 2025-01-25
Available Online: 2025-10-25

Abstract

Abstract

Objective To explore the relationship between cognitive impairment and metabolic indicators in patients with amyotrophic lateral sclerosis (ALS) in order to improve the early intervention rate of cognitive impairment in ALS patients. Methods The basic clinical data of 36 ALS patients who visited the Outpatient and Inpatient Departments of Gansu Provincial People' s Hospital from July 2022 to March 2024 were collected. Metabolic indexes such as serum creatinine (Cr), uric acid (UA), creatine kinase (CK), total cholesterol (TC), triglycerides (TG), high/low-density lipoprotein cholesterol (H/LDL-C) were also collected. Spearman and logistic regression were used to analyze the correlation between metabolic indexes and cognitive impairment. Results Univariate analysis: among the 36 ALS patients, 20 patients had cognitive impairment after minimum mental state examination (MMSE) evaluation, and the incidence of cognitive impairment was 55.56%. Compared with the non-cognitively impaired group, the cognitively impaired group had a higher percentage of females, higher ALSFRSr scores, higher CK and LDL-C, and lower education and UA, with statistically significant differences (P < 0.05). After Montreal cognitive assessment (MoCA) evaluation, 19 patients had cognitive impairment, and the incidence of cognitive impairment was 52.78%. Compared with the non-cognitively impaired group, the cognitively impaired group had a higher percentage of females, higher ALSFRSr scores, higher CK and LDL-C, and lower education and UA, and the differences were statistically significant (P < 0.05). Logistic regression analysis showed that female, high ALSFRSr score, and low UA were the main risk factors for cognitive impairment in patients (P < 0.05). Conclusion Female gender, ALSFRSr score, blood lipids, bulbar onset, education level and UA are associated with cognitive impairment in ALS patients. It is necessary to pay more attention to the above factors and intervene in time for ALS patients.
- Amyotrophic lateral sclerosis,
- Cognitive impairment,
- Metabolic markers

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References(26)

References

[1]	李瑞, 王国平. 运动神经元病的诊断与治疗[J]. 中华全科医学, 2019, 17(7): 1073-1074. http://zhqkyx.net/article/id/2df5e613-96c8-4c61-b366-03ed9ccf8ea2 LI R, WANG G P. Diagnosis and treatment of motor neuronal disease[J]. Chinese Journal of General Practice, 2019, 17(7): 1073-1074. http://zhqkyx.net/article/id/2df5e613-96c8-4c61-b366-03ed9ccf8ea2
[2]	FELDMAN E L, GOUTMAN S A, PETRI S, et al. Amyotrophic lateral sclerosis[J]. The Lancet, 2022, 400(10360): 1363-1380. doi: 10.1016/S0140-6736(22)01272-7
[3]	GOUTMAN S A, HARDIMAN O, AL-CHALABI A, et al. Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis[J]. The Lancet, 2022, 21(5): 480-493.
[4]	MEAD R J, SHAN N, REISER H J, et al. Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation[J]. Natrev Drug Discov, 2023, 22(3): 185-212. doi: 10.1038/s41573-022-00612-2
[5]	张秋丽, 张明. 肌萎缩侧索硬化症患者神经影像学研究进展[J]. 西安交通大学学报(医学版), 2023, 44(5): 668-673. ZHANG Q L, ZHANG M. Neuroimaging advances in patients with amyotrophic lateral sclerosis[J]. Journal of Xi'an Jiaotong University(Medical Sciences), 2023, 44(5): 668-673.
[6]	赵小泉, 卢祖能. 肌萎缩侧索硬化临床特征及预后因素研究进展[J]. 天津医药, 2023, 51(7): 694-697. ZHAO X Q, LU Z N. Advances in clinical characteristics and prognostic factors of amyotrophic lateral sclerosis[J]. Tianjin Medical Journal, 2023, 51(7): 694-697.
[7]	朱思佳, 俞立强, 方琪. 肌萎缩侧索硬化症患者认知损害和行为障碍的影像学研究进展[J]. 中国临床神经科学, 2024, 32(2): 220-227. ZHU S J, YU L Q, FANG Q. Multi-dimensional neuroimagings in amyotrophic lateral sclerosis with cognitive and behavioral disorders[J]. Chinese Journal of Clinical Neurosciences, 2024, 32(2): 220-227.
[8]	XIA K L, WITZEL S, WITZEL C, et al. Mutation-specific metabolic profiles in presymptomatic amyotrophic lateral sclerosis[J]. Eur J Neurol, 2023, 30(1): 87-95. doi: 10.1111/ene.15584
[9]	张一方, 张海鑫, 张纹菱, 等. 基于Meta分析的中国老年人轻度认知障碍风险评估模型的构建与验证[J]. 中华疾病控制杂志, 2023, 27(6): 705-710. ZHANG Y F, ZHANG H X, ZHANG W L, et al. Construction and validation of a risk assessment model for mild cognitive impairment in Chinese elderly based on Meta-analysis[J]. Chinese Journal of Disease Control & Prevention, 2023, 27(6): 705-710.
[10]	LEE Y G, PARK M, JEONG S H, et al. Alzheimer' s disease neuroimaging initiative. Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism[J]. Neurobiol Aging, 2021, 106: 223-231. doi: 10.1016/j.neurobiolaging.2021.05.003
[11]	刘潇, 秦星, 靳娇婷, 等. 肌萎缩侧索硬化症患者抑郁与代谢水平的相关性[J]. 西安交通大学学报(医学版), 2020, 41(6): 816-820. LIU X, QIN X, JIN J T, et al. Association between depression and metabolomic biomarkers of patients with amyotrophic lateral sclerosis[J]. Journal of Xi'an Jiaotong University(Medical Sciences), 2020, 41(6): 816-820.
[12]	VAN DAMME P, AL-CHALABI A, ANDERSEN P M, et al. European Academy of Neurology (EAN) guideline on the management of amyotrophic lateral sclerosis in collaboration with European Reference Network for Neuromuscular Diseases (ERN EURO-NMD)[J]. Eur J Neurol, 2024, 31(6): e16264. DOI: 10.1111/ene.16264.
[13]	郭晓敏, 魏爱芹, 刘宗伟, 等. 脑小血管病认知障碍患者脑电功率谱变化与中性粒细胞/淋巴细胞比值相关性及临床价值研究[J]. 陕西医学杂志, 2024, 53(3): 361-367. GUO X M, WEI A Q, LIU Z W, et al. Relationship between electroencephalographic power spectrum changes and NLR in CSVCI patients and its clinical value[J]. Shaanxi Medical Journal, 2024, 53(3): 361-367.
[14]	黄晓东, 罗伟良, 梁素琴, 等. 无症状性中重度颈内动脉狭窄患者认知功能障碍的临床研究[J]. 中国处方药, 2022, 20(4): 184-186. HUANG X D, LUO W L, LIANG S Q, et al. Correlation between asymptomatic moderate and severe carotid stenosis and cognitive impairment[J]. Journal of China Prescription Drug, 2022, 20(4): 184-186.
[15]	段倩倩, 张秋丽, 李海宁, 等. 肌萎缩侧索硬化患者丘脑局灶性损伤与认知功能障碍的相关性[J]. 西安交通大学学报(医学版), 2023, 44(5): 688-693. DUAN Q Q, ZHANG Q L, LI H N, et al. Focal thalamus alterations and their associations with cognitive impairment in patients with amyotrophic lateral sclerosis[J]. Journal of Xi'an Jiaotong University(Medical Sciences), 2023, 44(5): 688-693.
[16]	BENATAR M, WUU J, MCHUTCHISON C, et al. First International Pre-Symptomatic ALS Workshop. Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases[J]. Brain, 2022, 145(1): 27-44. doi: 10.1093/brain/awab404
[17]	KACEM I, ABIDA Y, FERCHICHI W, et al. Arabic adaptation of the Edinburgh Cognitive and behavioural Amyotrophic lateral Sclerosis screen(ECAS-AR)[J]. Rev Neurol(Paris), 2022, 178(8): 817-825. doi: 10.1016/j.neurol.2021.12.015
[18]	MOGLIA C, CALVO A, CANOSA A, et al. Cognitive and behavioral features of patients with amyotrophic lateral sclerosis who are carriers of the TARDBP pathogenic variant[J]. Neurology, 2024, 102(4): e208082. DOI: 10.1212/WNL.0000000000208082.
[19]	TELEANU D M, NICULESCU A G, LUNGU I I, et al. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases[J] Int J Mol Sci, 2022, 23(11): 5938. DOI: 10.3390/ijms23115938.
[20]	KUNITSKAYA N A, ARIEV A L. The role of hyperuricemia in the development of cognitive changes in the elderly[J]. Adv Gerontol, 2022, 35(5): 775-782.
[21]	KORCZOWSKA-ŁACKA I, SŁOWIKOWSKI B, PIEKUT T, et al. Disorders of endogenous and exogenous antioxidants in neurological diseases[J]. Antioxidants(Basel), 2023, 29, 12(10): 1811. DOI: 10.3390/antiox12101811.
[22]	AERQIN Q, JIA S S, SHEN X N, et al. Serum uric acid levels in neurodegenerative disorders: a cross-sectional study[J]. Alzheimers Dis, 2022, 90(2): 761-773. doi: 10.3233/JAD-220432
[23]	NISSEN S E, MENON V, NICHOLLS S J, et al. Bempedoic acid for primary prevention of cardiovascular events in statin-intolerant patients[J]. JAMA, 2023, 330(2): 131-140. doi: 10.1001/jama.2023.9696
[24]	AMES B N, CATHCART R, SCHWIERS E, et al. Uric acid provides an antioxidant defense in humans against oxidant and radical-caused aging and cancer: a hypothesis[J]. Proc Natl Acad Sci U S A, 1981, 78(11): 6858-6862. doi: 10.1073/pnas.78.11.6858
[25]	WALK D, NICHOLSON K, LOCATELLI E, et al. Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis[J]. Muscle Nerve, 2023, 67(5): 378-386. doi: 10.1002/mus.27807
[26]	李丽娜, 魏洪娟, 杨雪雯, 等. 中国老年人群阿尔茨海默病疾病负担的年龄-时期-队列分析[J]. 现代预防医学, 2024, 51(10): 1754-1759. LI L N, WEI H J, YANG X W, et al. Age period cohort analysis of Alzheimer' s disease burden in the elderly population in China[J]. Modern Preventive Medicine, 2024, 51(10): 1754-1759.

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Correlation between cognitive impairment and metabolic level in patients with amyotrophic lateral sclerosis

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