Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1152-1156
ZHANG Tingting, LI Hui, ZHANG Xingping. Bidirectional two-sample mendelian randomization investigation of the causal association between chronic kidney disease and renal function related indicators with insomnia[J]. Chinese Journal of General Practice, 2025, 23(7): 1152-1156. doi: 10.16766/j.cnki.issn.1674-4152.004086
Citation: ZHANG Tingting, LI Hui, ZHANG Xingping. Bidirectional two-sample mendelian randomization investigation of the causal association between chronic kidney disease and renal function related indicators with insomnia[J]. Chinese Journal of General Practice, 2025, 23(7): 1152-1156. doi: 10.16766/j.cnki.issn.1674-4152.004086
shu

Bidirectional two-sample mendelian randomization investigation of the causal association between chronic kidney disease and renal function related indicators with insomnia

doi: 10.16766/j.cnki.issn.1674-4152.004086
  • 1.

    The Fourth Affiliated Hospital of Xinjiang Medical University, Department of Endocrinology, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang 830099, China

Funds:

 82160873

 81960837

 81560762

 81260526

 国中医药人教函〔2022〕75号

 国中医药人教函〔2023〕85号

  • Received Date: 2024-11-06
    Available Online: 2025-10-25
    Abstract
  •   Objective  Chronic kidney disease (CKD) and renal function-related index abnormalities and insomnia often occur simultaneously in clinical practice. This study aimed to explore the potential causal association through Bidirectional two-sample Mendelian randomization (MR) analysis.  Methods  Single nucleotide polymorphisms (SNPs) that were strongly correlated with exposure factors and satisfied the linkage disequilibrium were screened from the published genome-wide association study (GWAS) dataset of European population as instrumental variables, and the SNPs were extracted from the corresponding outcomes for MR analysis. The inverse-variance weighted (IVW) method was used as the main causal inference result, and MR-Egger regression, weighted median, weighted mode, and simple mode methods were used as supplements and validation of IVW to explore the two-way causal association between chronic kidney disease and its related indicators and insomnia.  Results  There was no significant causal association between CKD, serum creatinine, serum uric acid, cystatin C and insomnia by IVW method. The OR (95% CI) were 0.997 (0.993-1.002), 0.924 (0.844-1.011), 1.008 (0.997-1.019), 1.001 (0.993-1.009), respectively (P>0.05). There was no significant causal association between insomnia and CKD and serum creatinine, serum uric acid, and cystatin C. The OR (95% CI) were 1.403 (0.625~3.151), 1.002 (0.983-1.021), 1.010 (0.871-1.170), and 0.954 (0.679-1.342), respectively (P>0.05). MR-Egger regression method, weighted median method, weighted mode method, and simple mode method further verified that there was no bidirectional causal relationship between CKD and its related indicators (serum creatinine, serum uric acid, cystatin C) and insomnia (P>0.05). In addition, the overall effect of level pleiotropy test, heterogeneity test, and leave one method analysis results were not affected by a single instrumental variable, further confirming the robustness and reliability of MR analysis results.  Conclusion  There is no obvious bidirectional causal association between CKD and renal function related indicators and insomnia.

     

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