Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1196-1198
TAN Kai, WANG Guoyu, WU Yulin, YANG Xiaoping, XU Zuliang, LIU Hongyu. Influence of intrahepatic fat on the evaluation of hepatic fibrosis using different T1 mapping techniques[J]. Chinese Journal of General Practice, 2025, 23(7): 1196-1198. doi: 10.16766/j.cnki.issn.1674-4152.004096
Citation: TAN Kai, WANG Guoyu, WU Yulin, YANG Xiaoping, XU Zuliang, LIU Hongyu. Influence of intrahepatic fat on the evaluation of hepatic fibrosis using different T1 mapping techniques[J]. Chinese Journal of General Practice, 2025, 23(7): 1196-1198. doi: 10.16766/j.cnki.issn.1674-4152.004096
shu

Influence of intrahepatic fat on the evaluation of hepatic fibrosis using different T1 mapping techniques

doi: 10.16766/j.cnki.issn.1674-4152.004096

  • Department of Radiology, Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Taizhou, Zhejiang 318000, China

Funds:

 2023KY1341

  • Received Date: 2024-10-15
    Available Online: 2025-10-25
    Abstract
  •   Objective  To explore the influence of intrahepatic fat on the assessment of hepatic fibrosis by different magnetic resonance T1 mapping methods.  Methods  A total of 140 patients with nonalcoholic fatty liver disease (NAFLD) treated at Taizhou Central Hospital from February 2021 to February 2024 were selected as the research objects. The proton density fat fraction of patients and liver T1 values obtained using different T1 mapping methods were collected. The relationship between T1 values and liver fat content was analyzed by Pearson correlation.  Results  T1 value of liver parenchyma on OP image was significantly higher than that on IP image and Water image, while the T1 value on Water image was higher than that on IP image (P < 0.05). The T1 value of liver parenchyma was weakly positively correlated with the proton density fat fraction (PDFF) in OP image (r=0.219, P=0.015), and negatively correlated with PDFF in IP image (r=-0. 499, P < 0.001). There is no correlation between the T1 value of liver parenchyma on Water image and PDFF (r=-0.138, P=0.130), while the absolute value of T1 value difference between OP image and IP image is also correlated with PDFF (r=0.373, P < 0.001; r=-0.258, P=0.004).  Conclusion  T1 mapping water sequence images obtained using Dixon water-fat separation imaging technology are minimally affected by hepatic fat, providing the most effective correction for fat-related interference in liver T1 measurements.

     

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