Volume 23 Issue 9
Sep.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(9): 1484-1487
CHEN Ling, LYU Daping, YAO Ming, WANG Yongquan, WANG Ling. Association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and severe intracranial/extracranial atherosclerotic stenosis[J]. Chinese Journal of General Practice, 2025, 23(9): 1484-1487. doi: 10.16766/j.cnki.issn.1674-4152.004160
Citation: CHEN Ling, LYU Daping, YAO Ming, WANG Yongquan, WANG Ling. Association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and severe intracranial/extracranial atherosclerotic stenosis[J]. Chinese Journal of General Practice, 2025, 23(9): 1484-1487. doi: 10.16766/j.cnki.issn.1674-4152.004160
shu

Association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and severe intracranial/extracranial atherosclerotic stenosis

doi: 10.16766/j.cnki.issn.1674-4152.004160
  • 1.

    Department of Neurology, the First Affiliated Hospital of Anhui Medical University/Anhui Public Health Clinical Center, Hefei, Anhui 230011, China

Funds:

 AHWJ2024Aa30270

 2024YKJ12

  • Received Date: 2025-04-03
    Available Online: 2025-11-17
    Abstract
  •   Objective  To investigate the correlation between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and severe atherosclerotic stenosis of intracranial/extracranial arteries. The study also seeks to provide a basis for the early screening of high-risk populations with severe intracranial/extracranial artery stenosis.  Methods  The present study is based on a cohort of 286 patients who underwent DSA examination in the Department of Neurology of the North District of the First Affiliated Hospital of Anhui Medical University from September 2018 to December 2024. The subjects were divided into two groups, namely the severe stenosis group (stenosis≥70% or occlusion, 197 cases) and the non-severe stenosis group (no stenosis or stenosis < 70%, 89 cases), according to the degree of stenosis. Clinical data and lipid profiles (total cholesterol and high-density lipoprotein cholesterol) were collected, and the NHHR was calculated. Multivariate logistic regression analysis was utilized to assess the independent association between NHHR and severe stenosis. Restricted cubic splines were used to analyze the nonlinear relationship between NHHR and the risk of stenosis. A stratified analysis was conducted in order to test the heterogeneity of the association.  Results  NHHR has been identified as an independent risk factor for severe atherosclerotic stenosis in intracranial and extracranial arteries (OR=1.141, P < 0.05). Subgroup analysis demonstrated consistent associations across different populations, with notably stronger effects observed in individuals aged 58-69 years (OR=1.474) and in patients with concurrent stenosis of both intracranial and extracranial arteries (OR=10.122, P < 0.05).  Conclusion  NHHR serves as a valuable indicator for predicting or evaluating severe atherosclerotic stenosis, particularly in the 58-69 age group and patients with concurrent stenosis of both intracranial and extracranial arteries.

     

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