Volume 23 Issue 9
Sep.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(9): 1488-1491
LI Siqing, LIANG Bing, TIAN Peiran, JIN Guoxi, JIANG Shuhong. Correlation between serum BDNF and RBP4 levels and depressive severity in patients with co-morbid depression and metabolic syndrome[J]. Chinese Journal of General Practice, 2025, 23(9): 1488-1491. doi: 10.16766/j.cnki.issn.1674-4152.004161
Citation: LI Siqing, LIANG Bing, TIAN Peiran, JIN Guoxi, JIANG Shuhong. Correlation between serum BDNF and RBP4 levels and depressive severity in patients with co-morbid depression and metabolic syndrome[J]. Chinese Journal of General Practice, 2025, 23(9): 1488-1491. doi: 10.16766/j.cnki.issn.1674-4152.004161
shu

Correlation between serum BDNF and RBP4 levels and depressive severity in patients with co-morbid depression and metabolic syndrome

doi: 10.16766/j.cnki.issn.1674-4152.004161
  • 1.

    Department of General Practice, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 202204295107020049

 Byycx23148

  • Received Date: 2024-10-08
    Available Online: 2025-11-17
    Abstract
  •   Objective  To investigate the relationship between serum levels of brain-derived neurotrophic factor (BDNF) and retinol binding protein 4 (RBP4) and the degree of depression in patients with metabolic syndrome (MS) co-morbid with major depressive disorder (MDD), as well as its diagnostic value. In order to provide a new theoretical basis for the prevention, diagnosis and treatment of MS comorbidities with MDD.  Methods  A total of 166 MS patients admitted to the First Affiliated Hospital of Bengbu Medical University from October 2023 to July 2024 were selected and divided into MS co-morbid MDD group (observation group, 114 cases) and MS group (control group, 52 cases) according to the presence or absence of co-morbid depressive disorder; 70 healthy people who had medical checkups in our hospital during the same period were selected and set up as the healthy group. In the MS co-morbid MDD group, they were divided into three subgroups according to the degree of depression: mild (n=53), moderate (n=39) and severe (n=22). The correlation between the serum BDNF and RBP4 levels and the HAMD score of MS patients with co-morbid MDD, and the diagnostic value of the two for MS co-morbid MDD were analyzed.  Results  The serum BDNF and RBP4 levels in the control and healthy groups were lower than those in the observation group, and the difference was statistical significance (P < 0.05). Comparison among the three subgroups: serum BDNF and RBP4 levels were higher in the mildly depressed and moderately depressed groups than those in the severely depressed group, and the difference was statistical significance (P < 0.05). Regression analysis showed that BDNF and RBP4 were protective factors for MS co-morbid of MDD (P < 0.05). ROC curves showed that the cut-off values of serum BDNF and RBP4 in patients of the observation group were 254.80 pg/mL and 37.50 mg/L, respectively, with a sensitivity of 85.96% and 61.40%, a specificity of 78.85%, and an area under the curve of 0.863 and 0.736, and the sensitivity of the combination of the two was 77.19%, the specificity was 84.62%, and the area under the curve was 0.887.  Conclusion  Detection of serum BDNF and RBP4 is valuable in diagnosing MDD in MS.

     

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