Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage

YU Xuanhua; ZHANG Weizhen; LIU Changquan; LYU Xuebing; WU Yueping; CHEN Rongyan; HUANG Huijuan

doi:10.16766/j.cnki.issn.1674-4152.004176

Volume 23 Issue 9

Sep. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(9): 1555-1560

YU Xuanhua, ZHANG Weizhen, LIU Changquan, LYU Xuebing, WU Yueping, CHEN Rongyan, HUANG Huijuan. Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage[J]. Chinese Journal of General Practice, 2025, 23(9): 1555-1560. doi: 10.16766/j.cnki.issn.1674-4152.004176

Citation:

YU Xuanhua, ZHANG Weizhen, LIU Changquan, LYU Xuebing, WU Yueping, CHEN Rongyan, HUANG Huijuan. Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage[J]. Chinese Journal of General Practice, 2025, 23(9): 1555-1560. doi: 10.16766/j.cnki.issn.1674-4152.004176

Citation:

YU Xuanhua, ZHANG Weizhen, LIU Changquan, LYU Xuebing, WU Yueping, CHEN Rongyan, HUANG Huijuan. Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage[J]. Chinese Journal of General Practice, 2025, 23(9): 1555-1560. doi: 10.16766/j.cnki.issn.1674-4152.004176

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Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage

doi: 10.16766/j.cnki.issn.1674-4152.004176

1.
Department of Rheumatology, People' s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350004, China

Funds:

2022J01851

2023GGA071

Received Date: 2024-12-22
Available Online: 2025-11-17

Abstract

Abstract

Objective To explore the correlation between changes in lymphocyte subsets in systemic lupus erythematosus (SLE) patients and disease activity, as well as the value in predicting different system impairments, in order to provide laboratory indicators for clinical assessment of SLE disease activity and system impairments. Methods A total of 85 SLE patients and 80 healthy controls admitted to People' s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from March 2023 to June 2024 were enrolled. The SLE patients were classified based on disease activity and damage to different systems. The counts of T lymphocyte subsets, B lymphocytes, and NK cells were measured. Correlation analysis and logistic regression analysis were used to explore the correlation between these parameters and SLE disease activity indicators and their predictive value for damage to different systems. Results The absolute counts of CD3⁺, CD4⁺, CD8⁺ T lymphocytes, B lymphocytes, and NK cells in SLE patients and the disease activity group were all lower than those in the healthy control group and the disease inactivity group. The absolute counts of CD3⁺, CD4⁺, and CD8⁺ T lymphocytes in the SLE renal lesion, hematological system involvement, arthritis, and serositis groups were all lower than those in the groups without corresponding system damage. The absolute count of NK cells was decreased in the renal lesion group. The absolute counts of CD3⁺ and CD8⁺ T lymphocytes were decreased in the infection group (P < 0.05). The combined detection of erythrocyte sedimentation rate (ESR), anti-dsDNA antibody, absolute counts of CD3⁺, CD4⁺, and CD8⁺ T lymphocytes, NK cells, and B lymphocytes had an AUC of 0.882 for predicting SLE disease activity. The combined detection of complement (C)3, absolute counts of CD3⁺, CD4⁺, and CD8⁺ T lymphocytes, and NK cells had an AUC of 0.833 for predicting SLE renal lesions. Conclusion Lymphocyte subsets are abnormal in SLE patients with disease activity, damage to different systems, and concomitant infections, etc. Combined detection of lymphocyte subsets and SLE disease activity indicators can assess SLE disease activity and predict damage to different systems.
- Systemic lupus erythematosus,
- Lymphocyte subsets,
- Disease activity,
- System damage

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Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage

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Changes in peripheral blood lymphocyte subsets in patients with systemic lupus erythematosus correlate with disease activity and predict the value of systemic damage

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