Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1830-1833
Dilihumaer·Aili, Zainula·Yiming, Zulipiyemu·Xier, PENG Hui. Analysis of risk factors affecting all-cause mortality in patients with coronary artery disease with mitral regurgitation[J]. Chinese Journal of General Practice, 2025, 23(11): 1830-1833. doi: 10.16766/j.cnki.issn.1674-4152.004238
Citation: Dilihumaer·Aili, Zainula·Yiming, Zulipiyemu·Xier, PENG Hui. Analysis of risk factors affecting all-cause mortality in patients with coronary artery disease with mitral regurgitation[J]. Chinese Journal of General Practice, 2025, 23(11): 1830-1833. doi: 10.16766/j.cnki.issn.1674-4152.004238
shu

Analysis of risk factors affecting all-cause mortality in patients with coronary artery disease with mitral regurgitation

doi: 10.16766/j.cnki.issn.1674-4152.004238

  • Department of Cardiology, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang 830000, China

Funds:

 2022B03009-3

  • Received Date: 2024-09-27
    Available Online: 2026-01-07
    Abstract
  •   Objective  The incidence of coronary artery disease (CAD) continues to increase, and mitral regurgitation (MR) is the most common heart valve disease. This study aims to investigate the clinical characteristics exhibited by patients diagnosed with coronary artery disease with MR and analyze the risk factors that have a detrimental effect on their prognosis.  Methods  This study comprised 813 patients diagnosed with coronary artery disease with mitral regurgitation, who were admitted to the Xinjiang Uygur Autonomous Region People's Hospital from January 2018 to December 2023, with a median follow-up period of 2.5 years, and the primary focus of the analysis was all-cause mortality. Patients were categorized into an endpoint event group (n=314) and a non-endpoint event group (n=499) according to the occurrence of an endpoint event. A Cox regression model was used to analyze the correlation between echocardiographic indices and prognosis in the present study, and the predictive ability of left atrial diameter (LAD), left ventricular end-diastolic internal diameter (LVEDD), and left ventricular end-systolic internal diameter (LVESD) for prognosis was assessed by the subjects' operating curves (ROCs), and the optimal cut-off values were determined by the Youden index, and analyzed by using the Kaplan-Meier survival curve.  Results  After making several adjustments to the data, it was found that LAD (HR=1.031, 95% CI: 1.015-1.048), LVEDD (HR=1.057, 95% CI: 1.043-1.071), LVESD (HR=1.046, 95% CI: 1.031-1.062) were all risk factors for the occurrence of endpoint events in patients with coronary heart disease and MR (P < 0.001). The ROC curve showed that LAD, LVEDD and LVESD could predict long-term all-cause death in patients with coronary heart disease and MR (AUC=0.666, 0.755, 0.761, P < 0.001), and the best cut-off values were 42.5 mm, 49.5 mm and 37.5 mm, respectively. The Kaplan-Meier survival curve showed that the survival rate of patients above the threshold was significantly reduced (log-rank χ2=59.737, 123.156, 171.803, P < 0.001).  Conclusion  Cardiac echocardiographic indices have been shown to possess a degree of predictive value regarding prognosis in patients suffering from coronary artery disease and mitral regurgitation, and the increase of LAD, LVEDD and LVESD has been identified as a risk factor for endpoint events in patients.

     

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