Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1842-1845
XU Pengfei, LI Rui, SHEN Nan, ZHOU Qianqian, WANG Li, ZHU Yuyou. sTREM-1 and MMP-9 in predicting futile recanalization after endovascular treatment in acute middle cerebral artery occlusion ischemic stroke[J]. Chinese Journal of General Practice, 2025, 23(11): 1842-1845. doi: 10.16766/j.cnki.issn.1674-4152.004241
Citation: XU Pengfei, LI Rui, SHEN Nan, ZHOU Qianqian, WANG Li, ZHU Yuyou. sTREM-1 and MMP-9 in predicting futile recanalization after endovascular treatment in acute middle cerebral artery occlusion ischemic stroke[J]. Chinese Journal of General Practice, 2025, 23(11): 1842-1845. doi: 10.16766/j.cnki.issn.1674-4152.004241
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sTREM-1 and MMP-9 in predicting futile recanalization after endovascular treatment in acute middle cerebral artery occlusion ischemic stroke

doi: 10.16766/j.cnki.issn.1674-4152.004241

  • Department of Neurology, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China

Funds:

 82471310

  • Received Date: 2025-04-03
    Available Online: 2026-01-07
    Abstract
  •   Objective  To analyze the influencing factors of futile recanalization after endovascular thrombectomy (EVT) in patients with acute middle cerebral artery occlusion stroke (MCAO-AIS), and to explore the predictive value of serum sTREM-1 and MMP-9 levels for futile recanalization.  Methods  A total of 115 MCAO-AIS patients who underwent EVT and achieved successful recanalization in the Department of Neurology, the First Affiliated Hospital of University of Science and Technology of China (USTC) from August 2020 to September 2022, were prospectively enrolled. The patients were divided into the meaningful recanalization and futile recanalization groups according to the mRS score 3 months after EVT. Independent influencing factors for futile recanalization were analyzed by multivariate logistic regression. The receiver operating characteristic curve was used to analyze the efficacy of sTREM-1 and MMP-9 in predicting futile recanalization.  Results  Compared with the meaningful recanalization group, the futile recanalization group had higher age, NIHSS score at admission, blood glucose, neutrophil-to-lymphocyte ratio, serum sTREM-1 and MMP-9 levels, and lower preoperative ASPECT score (P < 0.05). Multivariate logistic regression analysis showed that age (OR=1.060, P=0.030, 95% CI: 1.006-1.117), serum MMP-9 level (OR=1.007, P=0.019, 95% CI: 1.001-1.014), and serum sTREM-1 level (OR=1.009, P < 0.001, 95% CI: 1.004-1.014) were independent influencing factors for post-procedural futile recanalization. The AUC of sTREM-1 and MMP-9 for predicting futile recanalization were 0.837 and 0.763, respectively.  Conclusion  Age, serum sTREM-1 and MMP-9 level are independent influencing factors for futile recanalization in MCAO-AIS patients after EVT. sTREM-1 and MMP-9 are potential biomarkers for predicting futile recanalization.

     

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