Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1846-1849
CHEN Hao, XIAO Renyi, NI Xiaofeng, ZHOU Yili. Variation of serum calcium, parathyroid hormone and NLR, and their relationship between prognosis of patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2025, 23(11): 1846-1849. doi: 10.16766/j.cnki.issn.1674-4152.004242
Citation: CHEN Hao, XIAO Renyi, NI Xiaofeng, ZHOU Yili. Variation of serum calcium, parathyroid hormone and NLR, and their relationship between prognosis of patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2025, 23(11): 1846-1849. doi: 10.16766/j.cnki.issn.1674-4152.004242
shu

Variation of serum calcium, parathyroid hormone and NLR, and their relationship between prognosis of patients with papillary thyroid carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.004242

  • Department of Thyroid Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 LY20H160011

 Y2023494

  • Received Date: 2024-09-30
    Available Online: 2026-01-07
    Abstract
  •   Objective  Postoperative prognoses of papillary thyroid carcinoma (PTC) exhibit significant inter-patient variability, with some patients experiencing unfavourable outcomes. This study aims to investigate the impact of serum calcium, parathyroid hormone, and inflammatory markers on recurrence and metastasis in PTC patients.  Methods  A total of 87 patients with PTC undergoing surgical resection at the First Affiliated Hospital of Wenzhou Medical University were enrolled between January 2019 and January 2021. Patients were subjected to a three-year follow-up period after surgery in order to statistically analyze the recurrence and metastasis of the disease. The present study set out to compare the levels of peripheral blood calcium, PTH and NLR were compared before and after surgery. A comparison was made of the clinical data, levels of peripheral blood calcium, PTH and NLR in the good prognosis group and poor. The prognostic value of serum calcium, PTH and NLR was analyzed by receiver operating characteristic (ROC) curve analysis.  Results  Post-surgically, there was a significant decrease in the levels of peripheral blood calcium, PTH and NLR in patients with PTC (P < 0.05). After 3 years of follow-up, there were 37 cases (42.53%) exhibited signs of recurrence or metastasis. The level of peripheral blood calcium in the poor prognosis group was lower than that in the good prognosis group, PTH and NLR in the poor prognosis group were higher than those in the good prognosis group (P < 0.05). The two groups differed significantly two groups in terms of time from operation to 131Ⅰ treatment, preoperative lymph node metastasis, and tumor stage (P < 0.05). ROC curve analysis demonstrated that the area under the curve (AUC) value of calcium, PTH, NLR and combined detection for evaluating the prognosis of PTC patients was 0.724, 0.690, 0.734 and 0.929 (all P < 0.05).  Conclusion  Post-surgically, there is a marked decrease in the levels of peripheral blood calcium, PTH and NLR are significantly decreased in PTC patients. The combined detection of the three indexes has evaluation value for the prognosis of PTC patients.

     

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