Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1850-1853
CHANG Dongge, YANG Ning, YUAN Yongmei, TIAN Qi. Establish Nomogram for myocardial damage in emergency sepsis patients based on mitochondrial damage index, and evaluate its predictive efficacy[J]. Chinese Journal of General Practice, 2025, 23(11): 1850-1853. doi: 10.16766/j.cnki.issn.1674-4152.004243
Citation: CHANG Dongge, YANG Ning, YUAN Yongmei, TIAN Qi. Establish Nomogram for myocardial damage in emergency sepsis patients based on mitochondrial damage index, and evaluate its predictive efficacy[J]. Chinese Journal of General Practice, 2025, 23(11): 1850-1853. doi: 10.16766/j.cnki.issn.1674-4152.004243
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Establish Nomogram for myocardial damage in emergency sepsis patients based on mitochondrial damage index, and evaluate its predictive efficacy

doi: 10.16766/j.cnki.issn.1674-4152.004243

  • Emergency Department of Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, China

Funds:

 242102310120

  • Received Date: 2024-10-18
    Available Online: 2026-01-07
    Abstract
  •   Objective  The present study investigates the risk index of myocardial damage in patients with emergency sepsis based on mitochondrial damage index (MDI). In addition, the prediction model of Nomograph was constructed to verify its prediction efficiency.  Methods  A prospective analysis was performed on 156 patients with acute sepsis who were diagnosed and treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from March 2022 to March 2024, and they were divided into two groups: a myocardial injury group (98 cases) and non-myocardial injury group (58 cases) according to whether myocardial injury occurred. Peripheral venous blood was collected on the day of admission, and the MDI of serum T lymphocyte subsets, helper T cells (Th) and inhibitory T cells (Ts) were detected by flow cytometry. The indicators affecting myocardial injury in patients with emergency sepsis were analyzed by uni-factor and multi-factor analysis, and the prediction efficiency of Nomogram was analyzed by receiver operating characteristic curve (ROC).  Results  The myocardial injury group exhibited elevated levels of hyperlipidemia, pulmonary infection, abdominal infection, septic shock, E/A, CD3+, CD4+, CD8+, Th MDI positive and Ts MDI positive when compared to the myocardial injury group were higher than those in non-myocardial injury group (P < 0.05), and EF value was found to be lower in the myocardial injury group than that in the non-myocardial injury group (P < 0.05). Peritoneal infection, septic shock, ejection fraction (EF), Th MDI positive and Ts MDI positive are the influential factors for myocardial injury in emergency sepsis patients. The calibration curve demonstrated that the consistency index was 0.866 (95% CI: 0.773-0.945), the H-L goodness-of-fit test (χ2=6.476, P>0.05), and the area under the ROC curve was 0.829 (95% CI: 0.744-0.906). The sensitivity and specificity were found to be 80.70% and 72.00%, respectively.  Conclusion  Abdominal infection, septic shock, EF, Th MDI positive and Ts MDI positive are the influential factors for myocardial injury in emergency sepsis patients. The Nomograph model established in this study has been shown to be an effective in predicting myocardial injury.

     

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