Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1889-1891
HONG Yanqing, HU Chenliang. Factors influencing the occurrence of diabetic nephropathy and correlation analysis with non-HDL-C and TyG indices[J]. Chinese Journal of General Practice, 2025, 23(11): 1889-1891. doi: 10.16766/j.cnki.issn.1674-4152.004253
Citation: HONG Yanqing, HU Chenliang. Factors influencing the occurrence of diabetic nephropathy and correlation analysis with non-HDL-C and TyG indices[J]. Chinese Journal of General Practice, 2025, 23(11): 1889-1891. doi: 10.16766/j.cnki.issn.1674-4152.004253
shu

Factors influencing the occurrence of diabetic nephropathy and correlation analysis with non-HDL-C and TyG indices

doi: 10.16766/j.cnki.issn.1674-4152.004253

  • Department of Endocrinology, Huangshan People's Hospital, Huangshan, Anhui 245000, China

Funds:

 AHWJ2023BAc20027

  • Received Date: 2024-10-14
    Available Online: 2026-01-07
    Abstract
  •   Objective  To analyze the relationship between non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride glucose (TyG) index and diabetic nephropathy (DN), and to explore the risk factors for DN.  Methods  A retrospective analysis was conducted on 300 patients with type 2 diabetes mellitus (T2DM) who were admitted to Huangshan People's Hospital from July 2022 to July 2024. The patients were divided into the occurrence group (n=120) and non-occurrence group (n=180) according to the presence or absence of DN. The non-HDL-C and TyG index in the two groups were compared using a paired t-test, and the factors affecting DN were analyzed using a logistic regression analysis. The relationship between non-HDL-C, TyG index and DN was analyzed using Pearson's correlation coefficient.  Results  The mean levels of non-HDL-C [(4.98±1.10) mmol/L vs. (4.22±1.26) mmol/L, t=5.480, P < 0.05] and TyG index [(9.16±2.04) mmol/L vs. (7.90±1.75) mmol/L, t=5.714, P < 0.05] were higher in the occurrence group were higher than those in the non-occurrence group. The findings of this study indicate that non-HDL-C (OR=1.745, 95% CI: 1.318-2.311) and TyG index (OR=1.453, 95% CI: 1.219-1.732) are risk factors for DN in T2DM patients (P < 0.05). The present study found a positive correlation between non-HDL-C (r=0.405) and TyG index (r=0.498) and DN (P < 0.05).  Conclusion  The non-HDL-C and TyG index have been identified as risk factors for the development of DN in T2DM patients, and are closely associated with the occurrence of DN. In order to reduce the occurrence of DN, clinical combination and early targeted intervention are required.

     

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