Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1920-1924
QI Hongyang, LIN Xiuqin, ZHOU Jie. Evaluated the value of MRI multi-sequence in brain lesions among AD patients based on hidden structure model and data mining[J]. Chinese Journal of General Practice, 2025, 23(11): 1920-1924. doi: 10.16766/j.cnki.issn.1674-4152.004260
Citation: QI Hongyang, LIN Xiuqin, ZHOU Jie. Evaluated the value of MRI multi-sequence in brain lesions among AD patients based on hidden structure model and data mining[J]. Chinese Journal of General Practice, 2025, 23(11): 1920-1924. doi: 10.16766/j.cnki.issn.1674-4152.004260
shu

Evaluated the value of MRI multi-sequence in brain lesions among AD patients based on hidden structure model and data mining

doi: 10.16766/j.cnki.issn.1674-4152.004260
  • 1.

    Radiology Department, Shaoxing 7th People' s Hospital, Shaoxing, Zhejiang 312000, China

Funds:

 2023KY1271

  • Received Date: 2025-05-27
    Available Online: 2026-01-07
    Abstract
  •   Objective  Evaluate the diagnostic value of MRI multi-sequence combined examination for the degree of cognitive dysfunction in patients with Alzheimer' s disease (AD) based on hidden structure models and data mining.  Methods  A total of 203 AD patients (AD group) and 102 non-AD patients (control group) diagnosed and treated at Shaoxing 7th People' s Hospital from January 2021 to August 2024 were selected as the subjects in this study. The AD patients were divided into the following three groups according to their degree of cognitive dysfunction: mild, moderate and severe.  Results  The hippocampal volume and SN phase shift values in the AD group were lower than those in the control group, while the ADC value was higher (P < 0.05). The implicit structure model demonstrates a close relationship between AD, ADC, hippocampal volume, and the phase shift value of substantia nigra structure. The results of the Modeler data mining show that patients in the "high-risk brain lesion feature cluster" have a higher MMSE score, however, there is a potential risk of lesion. Patients in the "significant brain lesion feature cluster" exhibit more pronounced lesion features and lower MMSE scores. The severity group exhibited reduced volumes of the left and right hippocampus and the SN phase shift value when compared to the mild and moderate groups, and the ADC value in the severity group was higher than observed in the mild and moderate groups (P < 0.05). The cognitive function of AD patients was found to be negatively correlated with hippocampal volume and SN phase shift value, and positively correlated with ADC (P < 0.05). ROC curve analysis demonstrated that the AUC values of hippocampal volume, ADC, SN phase shift, and multi-sequence combined diagnosis of severe cognitive dysfunction in AD patients were 0.748, 0.673, 0.802 and 0.892.  Conclusion  MRI multi-sequence combined examination has been shown to have a certain value in the evaluation of cognitive dysfunction in AD patients, and the combination of hidden structure models and data mining techniques has been demonstrated to be conducive to providing an important reference basis for the early diagnosis and condition assessment of AD.

     

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