Volume 23 Issue 11
Nov.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(11): 1933-1936
KONG Lingchun, PAN Yajie, LIU Huixia, LI Jingjing, LING Yun, QIU Wenjing, ZOU Hong. Clinical study of Modified Taohong Siwu Decoction in the treatment of diabetic macular edema of Qi-Yin deficiency combined with blood stasis[J]. Chinese Journal of General Practice, 2025, 23(11): 1933-1936. doi: 10.16766/j.cnki.issn.1674-4152.004263
Citation: KONG Lingchun, PAN Yajie, LIU Huixia, LI Jingjing, LING Yun, QIU Wenjing, ZOU Hong. Clinical study of Modified Taohong Siwu Decoction in the treatment of diabetic macular edema of Qi-Yin deficiency combined with blood stasis[J]. Chinese Journal of General Practice, 2025, 23(11): 1933-1936. doi: 10.16766/j.cnki.issn.1674-4152.004263
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Clinical study of Modified Taohong Siwu Decoction in the treatment of diabetic macular edema of Qi-Yin deficiency combined with blood stasis

doi: 10.16766/j.cnki.issn.1674-4152.004263
  • 1.

    Department of Ophthalmology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Funds:

 81874384

 PW2021D-03

  • Received Date: 2024-12-09
    Available Online: 2026-01-07
    Abstract
  •   Objective  To observe the clinical efficacy of Modified Taohong Siwu Decoction (MTSD) combined with Ranibizumab in the treatment of diabetic macular edema (DME) and its influence on retinal microcirculation.  Methods  A total of 100 patients (100 eyes) with DME in the Ophthalmology Department of Shuguang Hospital from September 2022 to September 2023 were picked and randomly divided into two groups according to the random list method, with 50 cases and 50 eyes in each group. The control group was treated with intravitreal injection of Ranibizumab. The treatment group was treated with oral MTSD combined with intravitreal injection of Ranibizumab, and followed up for 3 months. TCM syndrome score, best corrected visual acuity, central macular thickness, superficial vascular density and superficial perfusion density in three zones and four places by OCTA in the two groups were measured and compared before and after treatment.  Results  The improvement in TCM symptoms in the treatment group was better than that in the control group (P < 0.05). The BCVA of the treatment group after treatment (4.80±0.21) was greater than that of the control group (4.64±0.30, F=34.857, P < 0.05). After treatment, both groups could reduce CMT (P < 0.001), but there was no statistically significant difference in the groups (P>0.05). After treatment in the treatment group, the VD and PD above and below the inner layer area and above and below the outer layer area increased compared with those before treatment (all P < 0.05). And except for the temporal side, the VD and PD in the central area, the upper part of the inner and outer layers, the nasal side and the lower part of the treatment group increased compared with the control group (P < 0.05).  Conclusion  Compared with simple intravitreal injection of Ranibizumab, MTSD combined in the treatment of DME can improve the discomfort symptoms of patients with Qi-Yin deficiency combined with blood stasis, improve the visual acuity, and improve the retinal microcirculation except the temporal side, which is an effective method for the adjuvant treatment of DME.

     

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