Volume 23 Issue 11
Nov.  2025
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CHEN Caifei, CAO Yi, WEI Lei, FU Hongyang. Dynamic effect of Qingre Sanjie Recipe on acne based on a DID model[J]. Chinese Journal of General Practice, 2025, 23(11): 1937-1941. doi: 10.16766/j.cnki.issn.1674-4152.004264
Citation: CHEN Caifei, CAO Yi, WEI Lei, FU Hongyang. Dynamic effect of Qingre Sanjie Recipe on acne based on a DID model[J]. Chinese Journal of General Practice, 2025, 23(11): 1937-1941. doi: 10.16766/j.cnki.issn.1674-4152.004264
shu

Dynamic effect of Qingre Sanjie Recipe on acne based on a DID model

doi: 10.16766/j.cnki.issn.1674-4152.004264
  • 1.

    Department of Dermatology, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, China

Funds:

 2025ZF031

  • Received Date: 2025-03-14
    Available Online: 2026-01-07
    Abstract
  •   Objective  Acne vulgaris (stagnation of blood-heat syndrome) is a common inflammatory dermatological condition that affects patients ' appearance, and the efficacy of current treatments is limited. This study applied a difference-in-differences (DID) model to analyze the dynamic effect of the Qingre Sanjie Recipe, aiming to provide evidence-based basis for an integrated traditional Chinese and western medicine diagnosis and treatment of acne based on syndrome classification.  Methods  A total of 92 patients with acne vulgaris (stagnation of blood-heat syndrome) admitted to our hospital from September 2023 to September 2024 were randomly divided into a control group (n=46) and an observation group (n=46). The control group received doxycycline capsules combined with fusidic acid cream, while the observation group was supplemented with Qingre Sanjie Recipe on the basis of the control group. The clinical efficacy, traditional Chinese medicine (TCM) syndrome score, inflammation-oxidation, and adverse reactions were compared between the two groups.  Results  The total clinical effective rate in the observation group was significantly higher than that in the control group [95.65% (44/46) vs. 82.61% (38/46), χ2=4.039, P=0.044]. Qingre Sanjie Recipe was significantly related to the decrease of TCM syndrome score of acne vulgaris patients (P < 0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α) and interleukin-17 (IL-17) decreased, while the levels of superoxide dismutase (SOD) increased. The levels of TNF-α and IL-17 in the observation group were lower than those in the control group, while the levels of SOD were higher than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the control group and the observation group [6.52% (3/46) vs. 13.04% (6/46), χ2=0.493, P=0.483].  Conclusion  The Qingre Sanjie Recipe is effective in treating acne vulgaris (stagnation of blood-heat syndrome), and it can regulate inflammatory-oxidative factors, reduce the score of TCM syndromes, and demonstrates safety.

     

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