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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2013-2016
DU Jia, TIAN Xiaojun, WANG Congcong, JI Jiyu. Predictive value of serum TSPO, BDNF, and TNF-α levels for post-stroke depression in patients with acute ischemic stroke[J]. Chinese Journal of General Practice, 2025, 23(12): 2013-2016. doi: 10.16766/j.cnki.issn.1674-4152.004280
Citation: DU Jia, TIAN Xiaojun, WANG Congcong, JI Jiyu. Predictive value of serum TSPO, BDNF, and TNF-α levels for post-stroke depression in patients with acute ischemic stroke[J]. Chinese Journal of General Practice, 2025, 23(12): 2013-2016. doi: 10.16766/j.cnki.issn.1674-4152.004280
shu

Predictive value of serum TSPO, BDNF, and TNF-α levels for post-stroke depression in patients with acute ischemic stroke

doi: 10.16766/j.cnki.issn.1674-4152.004280

  • Department of Neurology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453100, China

Funds:

 LHGJ20200490

 19A320031

 QN-2022-B13

  • Received Date: 2024-12-30
    Available Online: 2026-03-13
    Abstract
  •   Objective  To investigate the predictive value of serum translocator protein 18 kDa (TSPO), brain-derived neurotrophic factor (BDNF), and tumor necrosis factor-α (TNF-α) levels for post-stroke depression (PSD) in patients with acute ischemic stroke (AIS).  Methods  A total of 121 AIS patients admitted to the First Affiliated Hospital of Xinxiang Medical University from January 2022 to January 2024 were enrolled in this study. Based on the 17-item Hamilton depression rating scale assessment at 3 months after discharge, patients were divided into PSD group (n=38) and non-PSD group (n=83). Demographic data, clinical characteristics, and serum levels of TSPO, BDNF, and TNF-α were compared between the two groups. Logistic regression analysis was used to identify independent risk factors for PSD, and a receiver operating characteristic (ROC) curve was constructed to evaluate the predictive value of combined detection of serum TSPO, BDNF, and TNF-α levels for PSD.  Results  Serum TSPO and TNF-α levels were significantly higher in the PSD group than those in the non-PSD group (P < 0.05), while BDNF levels were significantly lower in the PSD group (P < 0.05). Logistic regression analysis showed that elevated serum TSPO (OR=2.065, 95% CI: 1.052-4.055, P < 0.05) and TNF-α (OR=1.374, 95% CI: 1.031-1.832, P < 0.05) levels were risk factors for PSD, while elevated BDNF level (OR=0.696, 95% CI: 0.521-0.929, P < 0.05) was a protective factor. ROC curve analysis showed that the combined detection of serum TSPO, BDNF, and TNF-α levels had a good predictive value for PSD, with an area under the curve of 0.797.  Conclusion  Serum TSPO, BDNF, and TNF-α levels are closely related to the development of PSD in patients with AIS. The combined detection of these three biomarkers may be helpful for early identification of high-risk populations for PSD, providing a basis for clinical prevention and treatment of PSD.

     

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