Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2030-2032
ZHANG Handong, WANG Gongteng, ZHANG Zhenbin, LI Guangxing, WANG Xufeng, ZHANG Wenqi, SUN Huaqiang, LI Shufeng. Observations on the efficacy and safety of celecoxib combined with diosmin in the treatment of moderate to severe knee osteoarthritis[J]. Chinese Journal of General Practice, 2025, 23(12): 2030-2032. doi: 10.16766/j.cnki.issn.1674-4152.004284
Citation: ZHANG Handong, WANG Gongteng, ZHANG Zhenbin, LI Guangxing, WANG Xufeng, ZHANG Wenqi, SUN Huaqiang, LI Shufeng. Observations on the efficacy and safety of celecoxib combined with diosmin in the treatment of moderate to severe knee osteoarthritis[J]. Chinese Journal of General Practice, 2025, 23(12): 2030-2032. doi: 10.16766/j.cnki.issn.1674-4152.004284
shu

Observations on the efficacy and safety of celecoxib combined with diosmin in the treatment of moderate to severe knee osteoarthritis

doi: 10.16766/j.cnki.issn.1674-4152.004284
  • 1.

    Department of Orthopedic Surgery, the First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, Shandong 250014, China

Funds:

 ZR2022MH128

  • Received Date: 2024-12-02
    Available Online: 2026-03-13
    Abstract
  •   Objective  To evaluate the clinical efficacy and safety of celecoxib combined with diosmin in the treatment of moderate to severe knee osteoarthritis (KOA) and to explore an optimized therapeutic strategy.  Methods  This prospective randomized controlled study included 86 KOA patients admitted to the First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital) from June to July 2024. Patients were assigned to the celecoxib group (control) or the celecoxib combined with diosmin group (observation) according to random number table method, with 43 cases in each group. The treatment duration was 8 weeks. The Western Ontario and McMaster Universities osteoarthritis index (WOMAC) scores, knee joint swelling scores and visual analogue scale (VAS) scores of the two groups of patients before taking the medicine, at 4 and 8 weeks after taking the medicine, and at 4, 8 and 12 weeks after discontinuation of treatment were evaluated. The adverse reactions were recorded.  Results  At 4 and 8 weeks post-treatment and 4, 8, and 12 weeks after discontinuation, the observation group showed significantly lower WOMAC scores [8 weeks after taking the medicine: 15 (13, 19) vs. 25 (19, 33), P < 0.001], knee swelling scores [8 weeks after taking the medicine: 1 (1, 1) vs. 1 (1, 2), P < 0.001], and VAS scores [8 weeks after taking the medicine: 3 (2, 3) vs. 3 (3, 4), P < 0.001] compared to the control group. The incidence of adverse reactions was lower in the observation group than in the control group [9.3% (4/43) vs. 37.2% (16/43), P=0.002].  Conclusion  The combination of celecoxib and diosmin provides superior efficacy in reducing pain and swelling in moderate to severe KOA compared to celecoxib alone, with a lower incidence of adverse events, making it a valuable clinical treatment option.

     

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