The application of negative vacuum stealing drainage technology combined with <i>Badu Shengji</i> Powder in diabetic foot ulcer patients

FAN Bobo; MA Haitao; CAI Gaopo; DAI Xuena; WANG Hanjie; ZHOU Tao

doi:10.16766/j.cnki.issn.1674-4152.004285

Volume 23 Issue 12

Dec. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(12): 2033-2037

FAN Bobo, MA Haitao, CAI Gaopo, DAI Xuena, WANG Hanjie, ZHOU Tao. The application of negative vacuum stealing drainage technology combined with Badu Shengji Powder in diabetic foot ulcer patients[J]. Chinese Journal of General Practice, 2025, 23(12): 2033-2037. doi: 10.16766/j.cnki.issn.1674-4152.004285

Citation:

FAN Bobo, MA Haitao, CAI Gaopo, DAI Xuena, WANG Hanjie, ZHOU Tao. The application of negative vacuum stealing drainage technology combined with Badu Shengji Powder in diabetic foot ulcer patients[J]. Chinese Journal of General Practice, 2025, 23(12): 2033-2037. doi: 10.16766/j.cnki.issn.1674-4152.004285

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The application of negative vacuum stealing drainage technology combined with Badu Shengji Powder in diabetic foot ulcer patients

doi: 10.16766/j.cnki.issn.1674-4152.004285

Department of Peripheral Vascular Surgery, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450000, China

Funds:

2022JDZX053

Received Date: 2025-06-11
Available Online: 2026-03-13

Abstract

Abstract

Objective To investigate the effects of negative vacuum sealing drainage (VSD) technology combined with Badu Shengji Powder on wound healing, serum C-reactive protein (CRP), interleukin-18 (IL-18), and glycogen synthase kinase 3β (GSK-3β) levels in patients with diabetic foot ulcer (DFU). Methods A total of 118 DFU patients admitted to the department of peripheral vascular, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, from January 2023 to May 2025, were separated into the observation group (n=59, VSD technology + Badu Shengji Powder) and the control group (n=59, VSD technology). The effects of the combination on wound healing, CRP, IL-18, GSK-3β, and other indices were analyzed. Results Wound area, wound depth, granulation growth and wound exudation scores of both groups significantly decreased after treatment, and the above scores in the observation group [(1.14±0.15) points, (1.23±0.15) points, (1.15±0.16) points and (1.21±0.15) points] were significantly lower than the other group [(1.62±0.17) points, (1.64±0.19) points, (1.72±0.19) points and (1.68±0.17) points, F=14.156, 11.278, 114.287, 13.564, all P < 0.001]; After treatment, CRP, white blood cell count (WBC), IL-18, GSK-3β, transforming growth factor (TGF-β1) and endostatin (ES) in the observation group were significantly lower than those in the control group (P < 0.001), while vascular diameter, blood flow velocity, resistance coefficient, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) significantly higher (P < 0.001). Conclusion VSD technology combined with Badu Shengji Powder can effectively promote DFU wound healing, regulate IL-18, GSK-3β, and other indicators, improve the hemodynamics of the back of the foot, and promote angiogenesis.
- Diabetic foot ulcer,
- Vacuum sealing drainage technology,
- Badu Shengji Powder,
- C-reactive protein,
- Interleukin-18,
- Glycogen synthase kinase 3β

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References(20)

References

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