Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2038-2041
YU Liang, YIN Lixia, NIU Minzhu, CHEN Siao, LIU Yike, GUO Yibing, GENG Zhijun. The relationship of RAB24 expression in gastric cancer with clinical prognosis and immune infiltration[J]. Chinese Journal of General Practice, 2025, 23(12): 2038-2041. doi: 10.16766/j.cnki.issn.1674-4152.004286
Citation: YU Liang, YIN Lixia, NIU Minzhu, CHEN Siao, LIU Yike, GUO Yibing, GENG Zhijun. The relationship of RAB24 expression in gastric cancer with clinical prognosis and immune infiltration[J]. Chinese Journal of General Practice, 2025, 23(12): 2038-2041. doi: 10.16766/j.cnki.issn.1674-4152.004286
shu

The relationship of RAB24 expression in gastric cancer with clinical prognosis and immune infiltration

doi: 10.16766/j.cnki.issn.1674-4152.004286
  • 1.

    Central Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2020A0563

  • Received Date: 2024-10-21
    Available Online: 2026-03-13
    Abstract
  •   Objective  To investigate the expression of RAB24 in the tissues of gastric cancer patients and its relationship with clinical prognosis, and to deeply analyze the role of RAB24 in regulating the immune infiltration of cancer cells.  Methods  A total of 105 patients who underwent radical gastric cancer surgery in First Affiliated Hospital of Bengbu Medical University from February 2013 and March 2018 was included. Immunohistochemical staining methods were used to analyze the expression of RAB24 in gastric cancer and to explore the relationship between it and patient survival. ROC curve, univariate, and multivariate analyses were performed to assess the predictive value of RAB24 for the 5-year postoperative survival rate and to identify risk factors influencing patient survival. GO and GSEA analyses were performed to predict the biological functions of RAB24 in gastric cancer. Bioinformatics online platforms were used to analyze the relationship between levels of RAB24 and immune infiltration as well as immune cells.  Results  High expression of RAB24 in gastric cancer tissue was significantly associated with poor patient prognosis (P < 0.05) and had a good predictive value for prognosis (AUC=0.844, P < 0.05). The results of Cox regression analysis showed that high expression of RAB24, CEA≥5 μg/L, CA199≥37 kU/L, T3-4 stage, and N2-3 stage were independent risk factors affecting the 5-year survival rate of gastric cancer patients (P < 0.05). Gene enrichment analysis suggested that RAB24 may participate in immune infiltration processes. The results of immune infiltration correlation analysis showed that the expression level of RAB24 was positively correlated with immune infiltration (P < 0.05), while the results of immune cell correlation analysis showed that the expression level of RAB24 was positively correlated with macrophages, myeloid derived suppressor cells, and Th17 cells (P < 0.05), and negatively correlated with effector memory CD4+T cells, Th2 cells, and memory B cells (P < 0.05).  Conclusion  The high expression of RAB24 in gastric cancer may affect the long-term prognosis of gastric cancer patients by influencing the infiltration of immune cells.

     

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