Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2046-2049
ZHANG Jianqiang, SHEN Ruile. Value of serum neurofilament light chain and glial fibrillary acidic protein levels in predicting neurological recovery and prognosis in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2025, 23(12): 2046-2049. doi: 10.16766/j.cnki.issn.1674-4152.004288
Citation: ZHANG Jianqiang, SHEN Ruile. Value of serum neurofilament light chain and glial fibrillary acidic protein levels in predicting neurological recovery and prognosis in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2025, 23(12): 2046-2049. doi: 10.16766/j.cnki.issn.1674-4152.004288
shu

Value of serum neurofilament light chain and glial fibrillary acidic protein levels in predicting neurological recovery and prognosis in patients with acute cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.004288

  • Department of Neurology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, China

Funds:

 SBGJ202302095

  • Received Date: 2025-08-11
    Available Online: 2026-03-13
    Abstract
  •   Objective  To investigate the impact of serum neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) levels on neurological injury and recovery in acute ischemic stroke (AIS) patients, providing evidence for personalized treatment.  Methods  A total of 129 AIS patients admitted to our hospital from January 2020 to December 2022 were included. According to the modified Rankin scale (mRS) score at 3 months post-discharge, patients were divided into a good prognosis group (mRS≤2, 83 cases) and a poor prognosis group (mRS>2, 46 cases). The clinical characteristics and serum levels of NfL and GFAP were compared between the two groups. The prognostic predictive value of these biomarkers and risk factors for poor neurological outcomes in AIS patients were analyzed.  Results  Compared with the good prognosis group, the poor prognosis group had significantly higher levels of NfL (15.2±6.3 vs. 22.8±8.5, t=5.777, P < 0.001) and GFAP [0.85 (0.62, 1.18) vs. 1.12 (0.79, 1.45), U=1 254.000, P=0.003], both of which were positively correlated with NIHSS scores and infarct volume. Multivariate regression analysis showed that elevated NfL (OR=1.861, 95% CI: 1.076-3.220, P=0.024) and GFAP (OR=2.979, 95% CI: 1.428-6.218, P=0.004) were independent influencing factors for poor prognosis in AIS patients. The combined detection of NfL and GFAP demonstrated higher predictive accuracy for neurological outcomes (AUC=0.809) compared to single biomarker detection.  Conclusion  Combined detection of serum NfL and GFAP levels is useful for early identification of AIS patients at risk of poor neurological outcomes and provides evidence for developing personalized treatment strategies.

     

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