Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2050-2053
XIA Yezi, SHEN Jiehong, SHI Nengneng, LI Xiaojing. Effects of auricular therapy combined with estazolam on sleep architecture and cognitive function in patients with senile dementia and sleep disorders[J]. Chinese Journal of General Practice, 2025, 23(12): 2050-2053. doi: 10.16766/j.cnki.issn.1674-4152.004289
Citation: XIA Yezi, SHEN Jiehong, SHI Nengneng, LI Xiaojing. Effects of auricular therapy combined with estazolam on sleep architecture and cognitive function in patients with senile dementia and sleep disorders[J]. Chinese Journal of General Practice, 2025, 23(12): 2050-2053. doi: 10.16766/j.cnki.issn.1674-4152.004289
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Effects of auricular therapy combined with estazolam on sleep architecture and cognitive function in patients with senile dementia and sleep disorders

doi: 10.16766/j.cnki.issn.1674-4152.004289
  • 1.

    Department of Geriatrics, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315000, China

Funds:

 2024ZL910

  • Received Date: 2025-05-28
    Available Online: 2026-03-13
    Abstract
  •   Objective  To address sleep disorders in patients with senile dementia, this study compared the therapeutic effects of auricular therapy combined with estazolam versus auricular therapy or estazolam monotherapy, and investigated the effects of the three treatment methods on sleep architecture, cognitive function, and relevant serological indicators, aiming to provide new insights for clinical treatment of senile dementia complicated with sleep disorders.  Methods  A total of 120 patients with senile dementia and sleep disorders admitted to the First Affiliated Hospital of Ningbo University from January 2024 to March 2025 were selected and randomly divided into the auricular therapy group A (30-min stimulation in the morning), the auricular therapy group B (30-min stimulation in the afternoon), the estazolam group, and the combination group (auricular therapy combined with estazolam), with 30 cases in each group. Sleep architecture, cognitive function, serum levels of melatonin (MT), cortisol (COR), and 5-hydroxytryptamine (5-HT), as well as adverse reactions, were compared across the four groups.  Results  After treatment, the combination group showed a lower arousal index (AI) and higher sleep efficiency index (SEI) and percentage of rapid eye movement (REM) sleep time to total sleep time (TST) compared with the other three groups (P < 0.05). After treatment, the mini-mental state examination (MMSE) score of the combination group (23.78±1.20) was higher than those of the other three groups (19.65±1.15, 19.70±1.08, 16.36±1.42, F=219.809, P < 0.001). After treatment, MT and 5-HT levels in the combination group were higher than those in the other three groups, while COR level was lower than those in the other three groups (P < 0.001). No statistically significant difference in the incidence of adverse reactions was observed among the four groups (P=0.309).  Conclusion  Auricular therapy combined with estazolam effectively improves sleep quality, enhances cognitive function, and modulates MT, COR, and 5-HT levels, making it a promising treatment for patients with senile dementia and sleep disorders.

     

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