Volume 23 Issue 12
Dec.  2025
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HU Lihong, YANG Xianling, LI Erna, ZHANG Zihua, WANG Xiaofan, LI Lijing, XU Meixian. The characteristics and risk factors of PICC related bloodstream infection in children[J]. Chinese Journal of General Practice, 2025, 23(12): 2080-2083. doi: 10.16766/j.cnki.issn.1674-4152.004296
Citation: HU Lihong, YANG Xianling, LI Erna, ZHANG Zihua, WANG Xiaofan, LI Lijing, XU Meixian. The characteristics and risk factors of PICC related bloodstream infection in children[J]. Chinese Journal of General Practice, 2025, 23(12): 2080-2083. doi: 10.16766/j.cnki.issn.1674-4152.004296

The characteristics and risk factors of PICC related bloodstream infection in children

doi: 10.16766/j.cnki.issn.1674-4152.004296
Funds:

 ZF2024181

 20190844

  • Received Date: 2025-07-11
    Available Online: 2026-03-13
  •   Objective  To investigate the characteristics of peripherally inserted central catheter (PICC) related bloodstream infection in children, and to analyze the risk factors.  Methods  A total of 1 700 children receiving PICC in Hebei Children' s Hospital from January 2018 to August 2023 were chosen. The differences in general information and catheterization-related conditions were investigated by questionnaire. The characteristics of PICC-related bloodstream infection in children were analyzed, and the risk factors of infection were analyzed by multivariate logistic regression analysis.  Results  A total of 1 700 questionnaires were distributed in this study, and 1 658 were effectively recovered, with a questionnaire recovery rate of 97.53%. Among 1 658 children with PICC, 38 cases had PICC-related bloodstream infection, with an infection rate of 2.29%, and they were included in the infection group. The remaining 1 620 cases were included in the non-infected group. The main pathogenic bacteria were Gram-negative bacilli, with a total of 22 strains (57.89%). The highest number of pathogenic bacteria was Acinetobacter baumannii (23.68%), followed by Enterobacter clacae (21.05%) and Candida parapsilosis (14.71%). The proportions of catheter indwelling time >2 weeks, catheterization frequency >3 times, and dressing change frequency < 3 days in the infection group were 55.26% (21/38), 60.53% (23/38), and 71.05% (27/38), respectively, which were all higher than 26.60% (431/1 620), 33.40% (541/1 620), and 15.37% (249/1 620) in the non-infection group. The differences were statistically significant (χ2=15.378, 12.177, 82.966, P < 0.05). Multivariate logistic regression analysis showed that catheter indwelling time >2 weeks, catheter times >3 times, dressing change frequency < 3 days were all risk factors for PICC-related infection in children (P < 0.05).  Conclusion  The pathogenic bacteria of PICC bloodstream infection in children are mainly closely related to gram-negative bacilli. Catheter indwelling time >2 weeks, catheter times >3 times, and dressing change frequency < 3 days were the risk factors of PICC bloodstream infection.

     

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  • [1]
    赵亚莉, 李玉华, 李纳新, 等. 原发性肝癌患者经外周静脉置入中心静脉导管相关性静脉血栓形成的影响因素分析[J]. 北京医学, 2023, 45(12): 1058-1061.

    ZHAO Y L, LI Y H, LI N X, et al. Analysis of the influencing factors of central venous catheter-related venous thrombosis in patients with primary liver cancer via peripheral venous insertion[J]. Beijing Medical Journal, 2023, 45(12): 1058-1061.
    [2]
    黄婷, 殷杰, 陈梅. 儿童先天性心脏病的危险因素及预后分析[J]. 贵州医科大学学报, 2023, 48(12): 1521-1525.

    HUANG T, YIN J, CHEN M. Risk factors and prognosis of children with congenital heart disease[J]. Journal of Guizhou Medical University, 2023, 48(12): 1521-1525.
    [3]
    尹萌萌, 胡群. 儿童中心静脉导管相关的血栓形成性及感染性并发症的预防和治疗[J]. 中国生育健康杂志, 2022, 33(1): 94-97.

    YIN M M, HU Q. Prevention and treatment of thrombogenic and infectious complications associated with central venous catheters in children[J]. Chin J Repro Health, 2022, 33(1): 94-97.
    [4]
    申玉洁, 李禄全, 张先红, 等. 多学科联合质量改进项目在早产儿中心静脉导管相关性血流感染中的促进作用[J]. 解放军护理杂志, 2022, 39(4): 85-88.

    SHEN Y J, LI L Q, ZHANG X H, et al. Effect of multidisciplinary quality improvement program on central line-associated blood stream infection in preterm infants[J]. Milit Nurs, 2022, 39(4): 85-88.
    [5]
    ARUN S, MURKI S, VARDHELLI V, et al. Comparison of UVC with PICC line for reducing central line associated blood stream infections in preterm neonates with birth weight < 1 250 g: an open-label randomized controlled trial[J]. Indian Pediatr, 2024, 61(11): 1017-1023. doi: 10.1007/s13312-024-3309-7
    [6]
    丁亚光, 王春立, 迟巍, 等. 基于改进科学降低儿童PICC导管相关性血流感染的循证护理实践[J]. 中国护理管理, 2024, 24(8): 1130-1135.

    DING Y G, WANG C L, CHI W, et al. Evidence-based nursing practice of reducing the incidence of PICC Catheter Related Bloodstream Infection in pediatric patients based on improvement science[J]. Chin Nurs Manage, 2024, 24(8): 1130-1135.
    [7]
    韩敏, 朱莉, 徐兵. 医护一体PDCA护理模式对新生儿PICC护理的效果观察[J]. 中华全科医学, 2021, 19(9): 1604-1607. doi: 10.16766/j.cnki.issn.1674-4152.002122

    HAN M, ZHU L, XU B. Observation on the effect of PDCA nursing model of integrated medical and nursing on newborn PICC nursing[J]. Chin J Gen Pract, 2021, 19(9): 1604-1607. doi: 10.16766/j.cnki.issn.1674-4152.002122
    [8]
    雷常彬, 刘珊珊, 蒋艳. 导管相关血流感染指南的质量评价及内容分析[J]. 护理学报, 2021, 28(23): 47-52.

    LEI C B, LIU S S, JIANG Y. Quality evaluation and content analysis of guidelines for catheter-associated bloodstream infections[J]. J Nurs, 2021, 28(23): 47-52.
    [9]
    赵霞, 段富交, 张小琴, 等. 肿瘤患者经外周静脉置入中心静脉导管发生导管相关感染危险因素分析[J]. 中华实用诊断与治疗杂志, 2015, 29(8): 809-811.

    ZHAO X, DUAN F J, ZHANG X Q, et al. Risk factors of peripherally inserted central catheter-related infection in tumor patients[J]. Journal of Chinese Practical Diagnosis and Therapy, 2015, 29(8): 809-811.
    [10]
    刘娟, 肖舒文, 张晓霞. 基于外文医学信息资源检索系统的经外周穿刺中心静脉导管研究现状文献计量学分析[J]. 华西医学, 2021, 36(8): 1102-1107.

    LIU J, XIAO S W, ZHANG X X. Research status of peripherally inserted central catheter: a bibliometric analysis based on foreign medical retrieval system[J]. West Chin Med J, 2021, 36(8): 1102-1107.
    [11]
    王童语, 林琴, 李旭英, 等. PICC维护时导管相关性血流感染预防措施应用现状调查[J]. 护理学杂志, 2023, 38(3): 49-53.

    WANG T Y, LIN Q, LI X Y, et al. Survey on application of preventive measures for catheter-related bloodstream infection in PICC maintenance[J]. J Nurs Sci, 2023, 38(3): 49-53.
    [12]
    SWAMINATHAN L, FLANDERS S, HOROWITZ J, et al. Safety and outcomes of midline catheters vs peripherally inserted central catheters for patients with short-term indications: a multicenter study[J]. JAMA Intern Med, 2022, 182(1): 50-58. doi: 10.1001/jamainternmed.2021.6844
    [13]
    刘蕾, 郑侠, 丁翊君. 新生儿经外周静脉置入中心静脉导管渗漏性胸腔积液的临床特征和原因分析[J]. 北京医学, 2025, 47(1): 82-84, 88.

    LIU L, ZHENG X, DING Y J. Clinical characteristics and cause analysis of peripherally inserted central venous catheter leakage-induced pleural effusion in newborns[J]. Beijing Medical Journal, 2025, 47(1): 82-84, 88.
    [14]
    李钦领, 王杨, 代会, 等. 基于重症患者PICC导管堵塞影响因素建立临床预警工具[J]. 中华全科医学, 2022, 20(10): 1637-1640.

    LI Q L, WANG Y, DAI H, et al. Establishment of clinical warning tool based on the influencing factors of PICC catheter occlusion in critically ill patients[J]. Chin J Gen Pract, 2022, 20(10): 1637-1640.
    [15]
    许燕萍, 商祯茹, DORAZIO R M, 等. 经外周静脉穿刺中心静脉置管患儿相关性血源感染的危险因素分析[J]. 中国当代儿科杂志, 2022, 24(2): 141-146.

    XU Y P, SHANG Z R, ROBERT M D, et al. Risk factors for peripherally inserted central catheterization-associated bloodstream infection in neonates[J]. Chin J Contempor Pediat, 2022, 24(2): 141-146.
    [16]
    徐海琳, 张智洁, 徐资涵, 等. 新生儿经外周静脉穿刺中心静脉置管相关血流感染病原菌及危险因素[J]. 中华医院感染学杂志, 2022, 32(21): 3347-3351.

    XU H L, ZHANG Z J, XU Z H, et al. Pathogenic bacteria isolated from neonates with PICC-related bloodstream infection and risk factors[J]. Chin J Nosocomiol, 2022, 32(21): 3347-3351.
    [17]
    夏巧湘, 方锦平, 卢小蕴, 等. 先天性心脏病患儿经外周静脉置入中心静脉导管相关血流感染现状和病原菌分布情况分析[J]. 中国妇幼保健, 2022, 37(3): 470-472.

    XIA Q X, FANG J P, LU X Y, et al. Analysis of current situation and pathogenic bacteria distribution of blood flow infection associated with central venous catheter implantation through peripheral vein in children with congenital heart disease[J]. Mater Child Health Care Chin, 2022, 37(3): 470-472.
    [18]
    徐晓蓬, 袁伯稳, 季凤华. 早产儿中心静脉导管相关血流感染的菌群特征及其相关基因表达变化[J]. 中国消毒学杂志, 2022, 39(7): 504-506.

    XU X P, YUAN B W, JI F H. Microflora characteristics and gene expression changes of central venous catheter-associated bloodstream infections in premature infants[J]. Chin J Disinfect, 2022, 39(7): 504-506.
    [19]
    刘佳, 和茵, 刘鑫. 肿瘤患者PICC导管相关性感染的危险因素及护理对策[J]. 昆明医科大学学报, 2021, 42(1): 173-176.

    LIU J, HE Y, LIU X. Risk factors and nursing strategies of PICC catheter associated infection in cancer patients[J]. Chin Mod Doctor, 2021, 42(1): 173-176.
    [20]
    曾兆兰, 史泽瑶, 杨茹, 等. 不同定位技术在新生儿PICC辅助置管中定位效果及安全性的网状meta分析[J]. 护士进修杂志, 2024, 39(10): 1058-1065.

    ZENG Z L, SHI Z Y, YANG R, et al. Network meta-analysis of location efficacy and safety of different positioning techniques in PICC placement of neonates[J]. J Nurs Train, 2024, 39(10): 1058-1065.
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