Correlation analysis between functional status and anxiety-depressive emotions in patients with ankylosing spondylitis

WEI Zhimin; ZHANG Jiaxin; WANG Lei; SONG Chuan; WANG Yiwen; JI Xiaojian; LI Gang; HUANG Feng

doi:10.16766/j.cnki.issn.1674-4152.004300

Volume 23 Issue 12

Dec. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(12): 2097-2100

WEI Zhimin, ZHANG Jiaxin, WANG Lei, SONG Chuan, WANG Yiwen, JI Xiaojian, LI Gang, HUANG Feng. Correlation analysis between functional status and anxiety-depressive emotions in patients with ankylosing spondylitis[J]. Chinese Journal of General Practice, 2025, 23(12): 2097-2100. doi: 10.16766/j.cnki.issn.1674-4152.004300

Citation:

WEI Zhimin, ZHANG Jiaxin, WANG Lei, SONG Chuan, WANG Yiwen, JI Xiaojian, LI Gang, HUANG Feng. Correlation analysis between functional status and anxiety-depressive emotions in patients with ankylosing spondylitis[J]. Chinese Journal of General Practice, 2025, 23(12): 2097-2100. doi: 10.16766/j.cnki.issn.1674-4152.004300

Citation:

WEI Zhimin, ZHANG Jiaxin, WANG Lei, SONG Chuan, WANG Yiwen, JI Xiaojian, LI Gang, HUANG Feng. Correlation analysis between functional status and anxiety-depressive emotions in patients with ankylosing spondylitis[J]. Chinese Journal of General Practice, 2025, 23(12): 2097-2100. doi: 10.16766/j.cnki.issn.1674-4152.004300

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Correlation analysis between functional status and anxiety-depressive emotions in patients with ankylosing spondylitis

doi: 10.16766/j.cnki.issn.1674-4152.004300

1.
Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China, Beijing 100031, China

Funds:

19BJZ41

Received Date: 2024-10-25
Available Online: 2026-03-13

Abstract

Abstract

Objective To explore the relationship between functional status and anxiety-depressive emotions in patients with ankylosing spondylitis (AS), and to assess potential influences of clinical medications on anxiety-depressive emotions of AS patients in different functional status. Methods This study included 148 AS patients treated at Outpatient Rheumatology Clinics in the First Medical Center of Chinese PLA General Hospital from March 2021 to June 2021. The Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI) were used to evaluate the functional status, while the self-rating depression scale (SDS) and the self-rating anxiety scale (SAS) were utilized to assess the emotional disorder. Linear or nonlinear correlation between functional status and anxiety-depressive emotions was analyzed, and potential influences of different treatments on proportions of patients accompanied with anxiety-depressive emotions in subgroups based on functional status were investigated. Results Among included AS patients, 30.41% (45/148) were accompanied with emotional disorder, in which proportions of anxiety and depression were 14.19% (21/148) and 22.97% (34/148) respectively. Significant linear correlations were found between BASFI and scores of SAS and SDS (P < 0.001), while the correlation between BASMI and the scores of SAS and SDS was not statistically significant (P > 0.05). In functional limitation subgroup (BASFI < 1.5), AS patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) exhibited lower proportion of depression than those treated without NSAIDs (P=0.024), whereas impacts of tumor necrosis factor inhibitor, conventional synthetic disease modifying antirheumatic drug, and traditional Chinese medicine on SDS showed no significant difference. The effects of medications on anxiety were statistically non-different. Conclusion There are significant correlations between functional status and anxiety-depressive emotions in AS patients. Treatment with NSAIDs may improve the depressive emotional status of AS patients with functional limitation.
- Ankylosing spondylitis,
- Functional limitation,
- Anxiety-depression,
- Correlation analysis

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References

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