Volume 23 Issue 12
Dec.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2101-2104
ZHENG Yanan, ZHANG Jixin, YAN Chenchen, WANG Yifei, JIAO Min. The correlation among anxiety, mental resilience and immune response in patients with colorectal cancer after chemotherapy[J]. Chinese Journal of General Practice, 2025, 23(12): 2101-2104. doi: 10.16766/j.cnki.issn.1674-4152.004301
Citation: ZHENG Yanan, ZHANG Jixin, YAN Chenchen, WANG Yifei, JIAO Min. The correlation among anxiety, mental resilience and immune response in patients with colorectal cancer after chemotherapy[J]. Chinese Journal of General Practice, 2025, 23(12): 2101-2104. doi: 10.16766/j.cnki.issn.1674-4152.004301
shu

The correlation among anxiety, mental resilience and immune response in patients with colorectal cancer after chemotherapy

doi: 10.16766/j.cnki.issn.1674-4152.004301

  • Department of Gastrointestinal Surgery, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China

Funds:

 20241845

  • Received Date: 2025-05-11
    Available Online: 2026-03-13
    Abstract
  •   Objective  To study the correlation among anxiety, mental resilience, and immune response in patients with colorectal cancer after chemotherapy, in order to provide a reference for clinical treatment.  Methods  A total of 140 patients with chemotherapy after colorectal cancer surgery, admitted to the First Affiliated Hospital of Hebei North University from May 2021 to January 2024, were chosen. The anxiety and mental resilience were evaluated by the Zung anxiety self-rating scale (SAS) and the Chinese version of the Connor-Davidson resilience scale (CD-RISC), and an enzyme-linked immunosorbent assay was used to detect immune response levels and the correlation was analyzed by Pearson correlation. Logistic regression was used to analyze the influencing factors of immune response ability.  Results  The results of single-factor repeated measurement showed that there were significant differences in SAS, tenacity, self-reliance and optimism score before chemotherapy, after 1 course and 3 courses of chemotherapy (P < 0.05), the levels of interleukin-2 (IL-2), IL-4, IL-10 and IL-17 also had significant differences (P < 0.05); The levels of IL-2 and IL-17 were positively correlated with SAS scores, and negatively correlated with scores of various dimensions of mental resilience; IL-4 and IL-10 levels were negatively correlated with SAS scores (r=0.767 and 0.703), and negatively correlated with scores of various dimensions of mental resilience (r=-0.674, -0.714, -0.674, -0.615, -0.643, -0.523); IL-4 and IL-10 levels were negatively correlated with SAS scores (r=-0.664, -0.736), and positively correlated with scores of mental resilience (r=0.502, 0.534, 0.481, 0.601, 0.622, 0.515, P < 0.05). Logistic regression analysis showed that TNM stage, SAS score, mental resilience score, educational level, and per capita monthly income were independent risk factors affecting the immune response ability of patients with colorectal cancer after chemotherapy (OR 95% CI: 1.130-15.990, 1.029-11.557, 1.327-5.841, 1.680-8.125, 1.626-12.630, P < 0.05).  Conclusion  The anxiety and psychological resilience of patients with postoperative chemotherapy for colorectal cancer may be related to the abnormal level of immune response.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    赵敏, 桑畅野, 闫长红. EEN+PN方案对直肠癌根治术围手术期患者营养和免疫指标及康复的影响[J]. 中华全科医学, 2022, 20(9): 1587-1589, 1611. doi: 10.16766/j.cnki.issn.1674-4152.002655

    ZHAO M, SANG C Y, YAN C H. Effect of EEN and PN scheme on the nutrition indicators, immunological function and rehabilitation in patients undergoing laparoscopic colorectal surgery[J]. Chin J Gen Pract, 2022, 20(9): 1587-1589, 1611. doi: 10.16766/j.cnki.issn.1674-4152.002655
    [2]
    孙富云, 王维鹏, 张会会, 等. 结直肠癌术后患者人格特质与抑郁, 焦虑症状的关联性[J]. 山东大学学报: 医学版, 2021, 59(7): 91-96.

    SUN F Y, WANG W P, ZHANG H H, et al. Correlation among personality traits and depression, anxiety symptoms in patients after colorectal cancer resection[J]. J Shandong Univ(Health Sci), 2021, 59(7): 91-96.
    [3]
    黄庆, 邹旻红, 蒋叶, 等. 错配修复功能缺陷的结直肠癌术后患者预后影响因素的分析[J]. 新医学, 2021, 52(7): 482-487.

    HUANG Q, ZOU M H, JIANG Y, et al. Analysis of prognostic factors for patients with colorectal cancer who have undergone surgery and have defects in mismatch repair function[J]. Journal of New Medicine, 2021, 52(7): 482-487.
    [4]
    BAZILIANSKY S, COHEN M. Post-treatment psychological distress among colorectal cancer survivors: relation to emotion regulation patterns and personal resources[J]. Int J Behav Med, 2021, 28(5): 591-601. doi: 10.1007/s12529-020-09952-y
    [5]
    郭志娟, 吉茹, 王振飞, 等. 结直肠癌患者外周血CTC改变与预后的关系[J]. 贵州医科大学学报, 2021, 46(5): 590-595.

    GUO Z J, JI R, WANG Z F, et al. The relationship between changes in circulating CTCs in patients with colorectal cancer and prognosis[J]. Journal of Guizhou Medical University, 2021, 46(5): 590-595.
    [6]
    胡根花, 张倩, 严丽洁, 等. 乳腺癌根治术患者术前焦虑的影响因素分析及其对术后恢复、细胞免疫功能和生命质量的影响[J]. 现代生物医学进展, 2023, 23(17): 3263-3267.

    HU G H, ZHANG Q, YAN L J, et al. Analysis of influencing factors of preoperative anxiety in patients undergoing radical mastectomy and its effect on postoperative recovery, cellular immune function and quality of life[J]. Prog in Mod Biomed, 2023, 23(17): 3263-3267.
    [7]
    中华医学会消化内镜学分会, 中国抗癌协会肿瘤内镜学专业委员会. 中国早期结直肠癌筛查及内镜诊治指南(2014, 北京)[J]. 中华医学杂志, 2015, 95(28): 2235-2252.

    Chinese Society of Digestive Endoscopy, Professional Committee of Tumor Endoscopy, Chinese Anticancer Association. Guidelines for early colorectal cancer screening and endoscopic diagnosis and treatment in China (2014, Beijing)[J]. Nati Med J Chin, 2015, 95(28): 2235-2252.
    [8]
    王文菁, 谭文艳. 验证性因子分析在焦虑自评量表中的应用[J]. 中国健康心理学杂志, 2011, 19(7): 781-783.

    WANG W J, TAN W Y. Confirmatory factor analysis of the Zung self-rating anxiety scale[J]. Chin J Health Psychol, 2011, 19(7): 781-783.
    [9]
    李静, 刘艳存, 冯韶, 等. 中文版Connor-Davidson心理弹性量表在冠心病患者中的信效度[J]. 临床心身疾病杂志, 2020, 26(5): 63-67, 102.

    LI J, LIU Y C, FENG S, et al. Reliability and validity of the Chinese version of CD-RISC among coronary heart disease patients[J]. J Clin Psychosom Dis, 2020, 26(5): 63-67, 102.
    [10]
    AMINISANI N, NIKBAKHT H A, SHOJAIE L, et al. Gender differences in psychological distress in patients with colorectal cancer and its correlates in the Northeast of Iran[J]. J Gastrointest Cancer. 2022, 53(2): 245-252. doi: 10.1007/s12029-020-00558-x
    [11]
    李梅娜, 王晓薇, 王亚宇, 等. Snyder希望理论干预对结直肠癌术后结肠造口患者负性情绪、希望水平的影响[J]. 癌症进展, 2023, 21(5): 570-573.

    LI M N, WANG X W, WANG Y Y, et al. Effect of Snyder hope theory intervention on negative emotion and hope level in patients with colorectal cancer undergoing colostomy[J]. Oncol Prog, 2023, 21(5): 570-573.
    [12]
    张江, 赵喜娟, 吴江, 等. 家庭赋权护理干预方案在肺癌放疗患者中的应用[J]. 昆明医科大学学报, 2021, 42(12): 169-176.

    ZHANG J, ZHAO X J, WU J, et al. Application of family empowerment nursing intervention program in patients with lung cancer undergoing radiotherapy[J]. J Kunming Med Univ, 2021, 42(12): 169-176.
    [13]
    刘佳欣, 王雁军. 认知行为疗法对接受放化疗的直肠癌患者不良情绪及免疫功能的效果[J]. 国际精神病学杂志, 2023, 50(4): 860-863.

    LIU J X, WANG Y J. The effect of cognitive behavioral therapy on adverse mood and immune function in patients with rectal cancer undergoing radiotherapy and chemotherapy chemoradiotherapy[J]. J Int Psychiat, 2023, 50(4): 860-863.
    [14]
    丁中航, 王晓辉, 顾晓芬, 等. 中晚期结直肠癌患者生活质量及健康相关影响因素分析[J]. 中华肿瘤防治杂志, 2024, 31(19): 1209-1215.

    DING Z H, WANG X H, GU X F, et al. Analysis of quality of life and health-related factors in patients with advanced colorectal cancer[J]. Chin J Cancer Prev Treat, 2024, 31(19): 1209-1215.
    [15]
    董飞男. 肿瘤化疗患者焦虑抑郁状态的相关影响因素研究[J]. 中国预防医学杂志, 2020, 21(1): 85-88.

    DONG F N. Study on anxiety, depression and related factors of cancer patients with chemotherapy[J]. Chin Prev Med, 2020, 21(1): 85-88.
    [16]
    中华护理学会伤口、造口、失禁护理专业委员会, 中国抗癌协会大肠癌整合护理专业委员会, 北京大学医学部循证护理研究中心, 等. 成人肠造口护理指南[J]. 新医学, 2025, 56(10): 937-944.

    The Wound, Ostomy and Incontinence Nursing Committee of the Chinese Nursing Association, the Integrated Cancer Care Committee of the Chinese Anti-Cancer Association, the Evidence-Based Nursing Research Center of Peking University Health Science Center, et al. Guidelines for adult enterostomy care[J]. Journal of New Medicine, 2025, 56(10): 937-944.
    [17]
    侯春立, 景凤敏, 陈连刚, 等. 恶性肿瘤知情患者首次化疗不同阶段中负性情绪发生情况及精神支持需求调查分析[J]. 实用医院临床杂志, 2021, 18(1): 8-11.

    HOU C L, JING F M, CHEN L G, et al. A survey of the incidence of negative emotions and spiritual support needs in informed patients with malignant tumor at different stage of their first chemotherapy[J]. Pract J Clin Med, 2021, 18(1): 8-11.
    [18]
    陈向文, 姜亚君, 于林冲, 等. 扶正解毒汤对结直肠癌术后化疗患者免疫功能及不良反应的影响[J]. 现代中西医结合杂志, 2022, 31(23): 3318-3321.

    CHEN X W, JIANG Y J, YU L C, et al. Effect of Fuzheng Jiedu Decoction on immune function and adverse reactions in patients with colorectal cancer after chemotherapy[J]. Mod J Integr Tradit Chin West Med, 2022, 31(23): 3318-3321.
    [19]
    刘波, 吴乔联, 张权昌. 腹腔镜以及开腹手术对老年结直肠癌患者术后肠功能恢复时间的影响[J]. 昆明医科大学学报, 2024, 45(1): 143-148.

    LIU B, WU Q L, ZHANG Q C. The effects of the laparoscopic and open surgery on the postoperative intestinal function recovery time in elderly patients with colorectal cancer[J]. J Kunming Med Univ, 2024, 45(1): 143-148.
    [20]
    王努, 马腾飞, 孙刚, 等. 喉癌患者术后焦虑状况与围手术期营养状况及免疫功能指标的相关性[J]. 肿瘤预防与治疗, 2021, 34(6): 527-530.

    WANG N, MA T F, SUN G, et al. Correlation between postoperative anxiety and perioperative nutrition status and immune functions for patients with laryngeal cancer[J]. J Cancer Contr Treat, 2021, 34(6): 527-530.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (19) PDF downloads(0) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return