Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2128-2131
CHU Meili, FANG Zhou, PENG Xuebing, WANG Bin, TONG Xiaolei, LI Shaomin, FANG Zhaohui. Observation on curative effect of Bushen Qiangxin Prescription combined with Dapagliflozin in treating heart failure with preserved ejection fraction[J]. Chinese Journal of General Practice, 2025, 23(12): 2128-2131. doi: 10.16766/j.cnki.issn.1674-4152.004307
Citation: CHU Meili, FANG Zhou, PENG Xuebing, WANG Bin, TONG Xiaolei, LI Shaomin, FANG Zhaohui. Observation on curative effect of Bushen Qiangxin Prescription combined with Dapagliflozin in treating heart failure with preserved ejection fraction[J]. Chinese Journal of General Practice, 2025, 23(12): 2128-2131. doi: 10.16766/j.cnki.issn.1674-4152.004307
shu

Observation on curative effect of Bushen Qiangxin Prescription combined with Dapagliflozin in treating heart failure with preserved ejection fraction

doi: 10.16766/j.cnki.issn.1674-4152.004307
  • 1.

    Department of Internal Medicine Ⅰ, Ningguo Hospital of Traditional Chinese Medicine, Ninguo, Anhui 242300, China

Funds:

 GXXT-2020-025

 2023CXMMTCM003

  • Received Date: 2025-04-21
    Available Online: 2026-03-13
    Abstract
  •   Objective  To observe the efficacy of Bushen Qiangxin Prescription combined with Dapagliflozin in the treatment of heart failure with preserved ejection fraction (HFpEF), and to explore the treatment of HFpEF with integrated traditional Chinese and Western medicine.  Methods  Seventy patients with HFpEF who were admitted to the Ningguo Hospital of Traditional Chinese Medicine from January 2022 to November 2024 were divided into observation group and control group according to the random number table method, with 35 patients in each group. Both groups received basic treatment primarily consisting of Dapagliflozin, and the observation group was additionally given Bushen Qiangxin Prescription. After 4 weeks, the traditional Chinese medicine (TCM) syndrome score, total effective rate, 6-minute walking distance (6MWD), N-terminal B-type natriuretic peptide precursor (NT-proBNP), and cardiac ultrasound parameters [left ventricular ejection fraction (LVEF), left atrial diameter (LAD), left ventricular posterior wall (LVPW), E/e', tricuspid regurgitation velocity(TRV)] were compared between the two groups.  Results  The total effective rate of TCM syndrome in the observation group was higher than that in the control group (97.1% vs. 68.6%, χ2=10.057, P < 0.01), the TCM pattern score decreased after treatment, and the 6MWD increased, and the observation group was better than the control group (P < 0.01); the level of NT-proBNP decreased, and the value and difference between the two groups were statistically significant after treatment, and the observation group was better (P < 0.01); the two groups had an increase in LVEF and a decrease in E/e' and TRV (P < 0.01), and the magnitude of improvement in the observation group was greater than that in the control group (P < 0.01), and there was no significant difference in LVPW and LAD between the two groups after treatment (P>0.05). No adverse reactions were observed in either group.  Conclusion  The addition of Bushen Qiangxin Prescription in the treatment of HFpEF based on Dapagliflozin can further reduce NT-proBNP, increase 6MWD, significantly improve TCM syndrome, and help improve left ventricular diastolic function, with good safety.

     

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