Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2153-2157
CAI Yayi, XU Dongdong, WANG Yijing. Analysis of the development trajectory and influencing factors of symptom burden in perioperative patients with oral cancer[J]. Chinese Journal of General Practice, 2025, 23(12): 2153-2157. doi: 10.16766/j.cnki.issn.1674-4152.004313
Citation: CAI Yayi, XU Dongdong, WANG Yijing. Analysis of the development trajectory and influencing factors of symptom burden in perioperative patients with oral cancer[J]. Chinese Journal of General Practice, 2025, 23(12): 2153-2157. doi: 10.16766/j.cnki.issn.1674-4152.004313
shu

Analysis of the development trajectory and influencing factors of symptom burden in perioperative patients with oral cancer

doi: 10.16766/j.cnki.issn.1674-4152.004313
  • 1.

    Department of Oral and Maxillofacial Surgery, Stomatology Hospital Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 LBQ20H140001

  • Received Date: 2024-10-28
    Available Online: 2026-03-13
    Abstract
  •   Objective  To investigate the status and evolutions of symptom burden among perioperative oral cancer patients at different stages of treatment, and to provide a scientific basis for developing targeted symptom management strategies.  Methods  A total of 210 patients diagnosed with oral cancer who underwent surgical treatment at the Affiliated Stomatology Hospital of Wenzhou Medical University and the First Affiliated Hospital of Wenzhou Medical University from January 2021 to December 2023 were selected as the study objects. Data were collected using self-designed questionnaires, the nutritional risk screening 2002, and the MD Anderson symptom scale-head and neck module (Chinese version). Assessments were conducted at three time points: before surgery (T1), 7 days after surgery (T2), and 1 month after discharge (T3). The trajectory and influencing factors of perioperative symptom burden in patients with oral cancer were analyzed by generalized estimation equation.  Results  A total of 210, 207, and 193 valid questionnaires were collected at T1, T2, and T3, respectively. At T1, the most common symptoms were pain (70.48%), difficulty in swallowing/chewing (59.52%), and mouth ulcers (57.62%). At T2, the predominant symptoms were difficulty in swallowing/chewing (89.85%), difficulty in speaking (89.37%), and mucus problems (83.09%). At T3, the main symptoms were numbness/tingling (89.12%), difficulty in swallowing/chewing (88.60%), and difficulty in speaking (88.60%). The results of generalized estimation equation showed that patients with occupational status as individuals, comorbidities, advanced stage, higher NRS score, and receiving adjuvant therapy experienced higher symptom burden (P < 0.05).  Conclusion  Perioperative oral cancer patients experience a high dynamic symptom burden that varies across disease stages. Clinical staff should strengthen the assessment, monitoring, and management of symptom burden, particularly for patients with comorbidities, stage Ⅳ disease, or oral nutritional risk, to improve overall postoperative outcomes.

     

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