Volume 23 Issue 12
Dec.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(12): 2170-2173
XU Weijie, LUO Yu, HE Wentao, XIE Junhui. A case of recurrent bilateral adrenal pheochromocytoma-VHL disease and literature review[J]. Chinese Journal of General Practice, 2025, 23(12): 2170-2173. doi: 10.16766/j.cnki.issn.1674-4152.004317
Citation: XU Weijie, LUO Yu, HE Wentao, XIE Junhui. A case of recurrent bilateral adrenal pheochromocytoma-VHL disease and literature review[J]. Chinese Journal of General Practice, 2025, 23(12): 2170-2173. doi: 10.16766/j.cnki.issn.1674-4152.004317
shu

A case of recurrent bilateral adrenal pheochromocytoma-VHL disease and literature review

doi: 10.16766/j.cnki.issn.1674-4152.004317

  • Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei 430030, China

  • Received Date: 2024-12-12
    Available Online: 2026-03-13
    Abstract
  • This paper reported a patient presented with recurrent bilateral adrenal pheochromocytoma combined with cervical medullary hemangioblastoma, renal cyst, and pancreatic cyst, she had a first-degree relative with renal clear cell carcinoma and was diagnosed as Von Hippel-Lindau (VHL) disease. Genetic testing further confirmed the diagnosis. We summarized the clinical characteristics of VHL disease with adrenal pheochromocytoma reported in the literatures in the past 10 years. Patients with bilateral, recurrent or metastatic pheochromocytoma, or with central angioblastoma, retinal hemangioblastoma, renal cancer, pancreatic neuroendocrine tumor, cyst and cystadenoma of the reproductive system should be highly suspected of VHL disease. We should carry out genetic testing and family investigation as to avoid missed diagnosis and misdiagnosis.

     

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