Volume 24 Issue 1
Jan.  2026
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(1): 31-34
CHEN Shengxi, ZHANG Panpan, CHEN Xinxin, WU Peiyan. Effect of auricular scraping on gastrointestinal hormone levels in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction[J]. Chinese Journal of General Practice, 2026, 24(1): 31-34. doi: 10.16766/j.cnki.issn.1674-4152.004323
Citation: CHEN Shengxi, ZHANG Panpan, CHEN Xinxin, WU Peiyan. Effect of auricular scraping on gastrointestinal hormone levels in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction[J]. Chinese Journal of General Practice, 2026, 24(1): 31-34. doi: 10.16766/j.cnki.issn.1674-4152.004323
shu

Effect of auricular scraping on gastrointestinal hormone levels in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction

doi: 10.16766/j.cnki.issn.1674-4152.004323

  • Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang 310018, China

Funds:

 2022ZB136

 2025ZL040

  • Received Date: 2025-07-10
    Available Online: 2026-04-01
    Abstract
  •   Objective  To explore the effect of auricular scraping on the levels of gastrointestinal hormones in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with gastrointestinal dysfunction, and to provide evidence for clinical management.  Methods  A total of 167 patients with AECOPD complicated with gastrointestinal dysfunction admitted to the First Affiliated Hospital of Zhejiang Chinese Medical University from March 2023 to March 2025 were randomly divided into the group A (83 cases) and the group B (84 cases). The group A were given drug treatment, and the group B were given drug treatment combined with auricular scraping to stimulate the vagus nerve. The gastrointestinal hormone levels, gastrointestinal symptoms, TCM symptom scores, clinical efficacy and adverse reactions of the two groups were observed.  Results  A significant interaction was observed among group, time point, and their interaction (group-by-time) for the levels of gastrin (GAS), pepsinogen Ⅰ (PG Ⅰ), and pepsinogen Ⅱ (PG Ⅱ, P < 0.05). The GAS, PG Ⅰ and PG Ⅱ of T2 and T3 in the two groups were increased (P < 0.05), and the GAS, PG Ⅰ and PG Ⅱ of T2 and T3 in the group B were higher than those in the group A (P < 0.05). A significant interaction was observed for the gastrointestinal symptom rating scale (GSRS) scores between groups, over time points, and for their interaction (group × time, P < 0.05). The GSRS scores of T2 and T3 in the two groups were decreased (P < 0.05), and the GSRS scores of T2 and T3 in the group B were lower than those in the group A (P < 0.05). The TCM syndrome scores of T2 and T3 in the two groups were decreased (P < 0.05), and the TCM syndrome scores of T2 and T3 in the group B were lower than those in the group A (P < 0.05). The total effective rate of group B was higher than that of group A [91.67% (77/84) vs. 78.31% (65/83), χ2=5.848, P=0.016]. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).  Conclusion  The combination of medication and auricular scraping therapy, which stimulates the vagus nerve can improve the gastrointestinal hormone level of AECOPD patients with gastrointestinal dysfunction, reduce gastrointestinal symptoms and clinical symptoms of traditional Chinese medicine, improve the clinical efficacy, and has high safety.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    史月欣, 晏军, 吴彩军, 等. 慢性阻塞性肺疾病患者不同中医证型与血清促炎因子及PD-1、PD-L1的相关性研究[J/OL]. 中国中医基础医学杂志, 1-10[2025-12-15]. https://doi.org/10.19945/j.cnki.issn.1006-3250.20250930.003.

    SHI Y X, YAN J, WU C J, et al. A Study on the Correlation between Different Traditional Chinese Medicine Syndromes in Patients with Chronic Obstructive Pulmonary Disease and Serum Inflammatory Factors as Well as PD-1 and PD-L1[J/OL]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 1-10[2025-12-15]. https://doi.org/10.19945/j.cnki.issn.1006-3250.20250930.003.
    [2]
    QIAN Y, CAI C T, SUN M Q, et al. Analyses of factors associated with acute exacerbations of chronic obstructive pulmonary disease: a review[J]. Int J Chron Obstruct Pulmon Dis, 2023, 11(18): 2707-2723.
    [3]
    寇育乐, 谭曦舒, 李向文, 等. 清肺化痰逐瘀汤对COPD急性加重期合并胃肠功能障碍临床观察[J]. 中国中医急症, 2024, 33(10): 1814-1818.

    KOU Y L, TAN X S, LI X W, et al. Clinical observation on Qingfei Huatan Zhuyu Decoction in treating acute exacerbation of COPD complicated with gastrointestinal dysfunction[J]. Journal of Emergency in Traditional Chinese Medicine, 2024, 33(10): 1814-1818.
    [4]
    宿希, 隋丰秋, 王永明, 等. 血清白细胞介素-37对慢性阻塞性肺疾病急性加重期患者预后的预测作用[J]. 中国临床研究, 2025, 38(1): 105-109.

    SU X, SUI F Q, WANG Y M, et al. Predictive role of serum interleukin-37 on prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Chinese Journal of Clinical Research, 2025, 38(1): 105-109.
    [5]
    ZHU H Z, LI C Y, LIU L J, et al. Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease: a multi-centre, randomised, double-blind, placebo-controlled trial[J]. J Integr Med, 2024, 22(5): 561-569. doi: 10.1016/j.joim.2024.07.003
    [6]
    GUO W, LI X L, ZHAO H L, et al. Effectiveness of Chinese herbal medicine combined with conventional medicine on acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis[J]. J Tradit Chin Med, 2023, 43(2): 212-220.
    [7]
    何洁, 刘婧, 赵锐, 等. 慢性阻塞性肺疾病患者不良结局影响因素及血清NLR PA PCT水平对其预测价值[J]. 河北医学, 2025, 31(12): 2049-2055.

    HE J, LIU J, ZHAO R, et al. Influencing Factors of Adverse Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Predictive Value of Serum NLR PA and PCT Levels[J]. Hebei Medicine, 2025, 31(12): 2049-2055.
    [8]
    邢帅, 张盼盼, 邵旭鹏, 等. 清金化痰汤联合西医常规治疗对慢性阻塞性肺疾病急性加重期患者临床疗效的Meta分析[J]. 中国中医急症, 2024, 33(4): 571-576.

    XING S, ZHANG P P, SHAO X P, et al. Meta-analysis of clinical efficacy of Qingjin Huatan Decoction combined with conventional western medicine in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Emergency in Traditional Chinese Medicine, 2024, 33(4): 571-576.
    [9]
    杨小娟, 刘辉, 储著华. 解毒承气汤联合多潘立酮片治疗AECOPD(痰热壅肺证)患者胃肠功能障碍的疗效观察[J]. 中国中医急症, 2024, 33(4): 644-647.

    YANG X J, LIU H, CHU Z H. Efficacy observation of Jiedu Chengqi Decoction combined with Domperidone Tablets in treating gastrointestinal dysfunction in AECOPD patients (syndrome of phlegm-heat obstructing the lung)[J]. Journal of Emergency in Traditional Chinese Medicine, 2024, 33(4): 644-647.
    [10]
    中华医学会呼吸病学分会慢性阻塞性肺疾病学组, 中国医师协会呼吸医师分会慢性阻塞性肺疾病工作委员会. 慢性阻塞性肺疾病诊治指南(2021年修订版)[J]. 中华结核和呼吸杂志, 2021, 44(3): 170-205.

    Chronic Obstructive Pulmonary Disease Group of Respiratory Disease Branch of Chinese Medical Association; Chronic Obstructive Pulmonary Disease Working Committee of Respiratory Physician Branch of Chinese Medical Doctor Association. Guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease (revised version 2021)[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2021, 44(3): 170-205.
    [11]
    中华医学会消化病学分会. 肠屏障功能障碍临床诊治建议[J]. 中华消化杂志, 2006, 26(9): 620.

    Gastroenterology Branch of Chinese Medical Association. Clinical diagnosis and treatment recommendations for intestinal barrier dysfunction[J]. Chinese Journal of Digestion, 2006, 26(9): 620.
    [12]
    张红霞, 杨程, 陈晶, 等. 清肺化痰健脾活血法联合西医治疗慢性阻塞性肺疾病急性加重期的疗效观察及对肺功能指标、炎症水平的影响[J]. 辽宁中医杂志, 2022, 49(8): 113-116.

    ZHANG H X, YANG C, CHEN J, et al. Efficacy observation of Qingfei Huatan Jianpi Huoxue method combined with western medicine in treatment of acute exacerbation of chronic obstructive pulmonary disease and its influence on pulmonary function indexes and inflammatory levels[J]. Liaoning Journal of Traditional Chinese Medicine, 2022, 49(8): 113-116.
    [13]
    谷思薇, 唐鸿, 林翠萍, 等. 清肺化痰方联合虎符铜砭刮痧治疗痰热壅肺型慢性阻塞性肺疾病急性加重期的临床疗效[J]. 实用心脑肺血管病杂志, 2025, 33(5): 16-20.

    GU S W, TANG H, LIN C P, et al. Clinical efficacy of Qingfei Huatan Recipe combined with tiger talisman copper needle scraping in treatment of acute exacerbation of chronic obstructive pulmonary disease of phlegm-heat obstructing lung type[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2025, 33(5): 16-20.
    [14]
    金宇兰, 王姣, 韩一骄, 等. 济川煎加味治疗慢性阻塞性肺疾病急性加重期合并胃肠功能损伤(阳虚便秘型)的疗效研究[J]. 中华全科医学, 2025, 23(5): 794-797, 880. doi: 10.16766/j.cnki.issn.1674-4152.004003

    JIN Y L, WANG J, HAN Y J, et al. Study on efficacy of modified Jichuan Decoction in treating acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal injury (yang deficiency and constipation type)[J]. Chinese Journal of General Practice, 2025, 23(5): 794-797, 880. doi: 10.16766/j.cnki.issn.1674-4152.004003
    [15]
    侯冠华, 李伟, 邢移楠, 等. 慢性阻塞性肺疾病合并代谢综合征的炎症特征及对疾病进展的影响[J]. 中华实用诊断与治疗杂志, 2025, 39(3): 221-224.

    HOU G H, LI W, XING Y N, et al. Inflammatory characteristics of chronic obstructive pulmonary disease combined with metabolic syndrome and their impacts on disease progression[J]. Journal of Chinese Practical Diagnosis and Therapy, 2025, 39(3): 221-224.
    [16]
    王环芬, 应尚艳. 泻白散联合调胃承气汤治疗COPD急性加重期(痰热壅肺证)胃肠功能障碍的疗效观察[J]. 中国中医急症, 2023, 32(1): 139-141.

    WANG H F, YING S Y. Efficacy observation of Xiebai Powder combined with Tiaowei Chengqi Decoction in treating gastrointestinal dysfunction in acute exacerbation of COPD (syndrome of phlegm-heat obstructing the lung)[J]. Journal of Emergency in Traditional Chinese Medicine, 2023, 32(1): 139-141.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (37) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return