Volume 24 Issue 1
Jan.  2026
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WAN Haiyang, XU Weiqiang, GU Mingli. The prognostic value of systemic immune-inflammation index and fibrinogen to prealbumin ratio in prostate cancer[J]. Chinese Journal of General Practice, 2026, 24(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.004328
Citation: WAN Haiyang, XU Weiqiang, GU Mingli. The prognostic value of systemic immune-inflammation index and fibrinogen to prealbumin ratio in prostate cancer[J]. Chinese Journal of General Practice, 2026, 24(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.004328
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The prognostic value of systemic immune-inflammation index and fibrinogen to prealbumin ratio in prostate cancer

doi: 10.16766/j.cnki.issn.1674-4152.004328

  • Department of Urology, the Second Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233040, China

Funds:

 2023AH040284

  • Received Date: 2025-01-04
    Available Online: 2026-04-01
    Abstract
  •   Objective  To investigate the prognostic value of the systemic immune-inflammation index (SII) and fibrinogen to prealbumin ratio (FPR) in patients with prostate cancer, so as to provide evidence for the outcome of postoperative patients.  Methods  A total of 175 patients who underwent radical prostatectomy (RP)in the Department of Urology, the Second Affiliated Hospital of Bengbu Medical University from January 2014 to September 2020 were enrolled as subjects, and the relevant clinical data and follow-up information were collected. The optimal cut-off values of SII and FPR were determined using the ROC curves. Based on these cut-offs, patients were divided into high and low SII groups, and high and low FPR groups. The clinicopathological features of prostate cancer patients with different SII and FPR groups were analyzed, and Kaplan-Meier curves were established to analyze the PFS and OS. The Cox proportional hazards model was used to analyze the risk factors for PFS and OS of prostate cancer.  Results  The cut-off values of SII and FPR were 575.13 and 13.75, respectively. There were statistically significant differences in positive margin status, postoperative pathological stage among patients with different SII groups, and seminal vesicle invasion and positive margin status among patients with different FPR groups (P < 0.05). Survival analysis showed that PFS and OS in the low SII group and low FPR group were higher than those in the high SII group and high FPR group at 3 and 5 years after surgery, respectively. Compared with the combination of SII and FPR 0 and 1 groups, the 5-year PFS and OS of group 2 were the lowest, and the difference was statistically significant (P < 0.001). Multivariate analysis showed that preoperative tPSA, SII, and FPR were independent prognostic factors affecting PFS; margin status, SII, and FPR were independent prognostic factors affecting OS.  Conclusion  Both SII and FPR can be used as prognostic indicators for patients with prostate cancer, and the combination of the two has better predictive accuracy.

     

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