Volume 24 Issue 1
Jan.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(1): 59-62
TIAN Aiping, WANG Fuchun, MAO Yongwu, LI Qiong, LI Ziyi, ZHANG Wanjie, MAO Xiaorong, JIANG Zhenxiu. A clinical study on pathological injury patterns and factors influencing hormone response in patients with autoimmune hepatitis[J]. Chinese Journal of General Practice, 2026, 24(1): 59-62. doi: 10.16766/j.cnki.issn.1674-4152.004329
Citation: TIAN Aiping, WANG Fuchun, MAO Yongwu, LI Qiong, LI Ziyi, ZHANG Wanjie, MAO Xiaorong, JIANG Zhenxiu. A clinical study on pathological injury patterns and factors influencing hormone response in patients with autoimmune hepatitis[J]. Chinese Journal of General Practice, 2026, 24(1): 59-62. doi: 10.16766/j.cnki.issn.1674-4152.004329
shu

A clinical study on pathological injury patterns and factors influencing hormone response in patients with autoimmune hepatitis

doi: 10.16766/j.cnki.issn.1674-4152.004329
  • 1.

    Department of Hepatology, the First Hospital of Lanzhou University, Lanzhou, Gansu 730013, China

Funds:

 24YFFA037

 21JR7RA365

  • Received Date: 2025-01-26
    Available Online: 2026-04-01
    Abstract
  •   Objective  To analyze the clinical characteristics and liver biopsy-assessed pathological injury patterns in patients with autoimmune hepatitis (AIH) and to explore factors influencing the hormone response, aiming to provide new insights for clinical diagnosis and treatment.  Methods  We retrospectively analyzed data from 84 AIH patients diagnosed by liver biopsy and treated with glucocorticoids at the First Hospital of Lanzhou University from December 2020 to December 2022. Clinical data, liver biopsy information, and follow-up data were collected. Patients were divided into two groups based on their hormone response within 6 months: a complete response group (n=52) and an incomplete response or non-response group (n=32). Based on liver biopsy results, patients were further categorized into Group A (lobulitis, n=12), Group B (lobulitis combined with interface hepatitis, n=23), and Group C (interface hepatitis, n=49). We employed t-tests, Chi-square tests, non-parametric tests, and binary logistic regression to analyze the impact of pathological injury patterns and other factors on hormone response within 6 months in AIH patients.  Results  Among the 84 patients, 76.2% were female (n=64), and 23.8% were male (n=20), with a mean age of (50.6±11.4) years. Significant differences were observed between the two response groups in immunoglobulin G (IgG) levels, immunoglobulin M (IgM) levels, and pathological injury patterns (P < 0.05). Multivariate analysis revealed that IgG, IgM, and pathological injury patterns were independent factors influencing hormone response within 6 months in AIH patients (P < 0.05).  Conclusion  AIH patients with lower serum IgG levels were more likely to achieve a complete hormone response within 6 months compared to those with higher levels. Compared to AIH patients with interface hepatitis as the predominant pathological injury pattern, patients with lobulitis combined with interface hepatitis were more likely to achieve a complete hormone response to glucocorticoid therapy within 6 months.

     

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