Volume 24 Issue 1
Jan.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(1): 67-70
QIAN Wei, ZHANG Congli, ZHANG Yunchun. Application of Remazolam combined with Esketamine in tonsillar-adenoidectomy in children[J]. Chinese Journal of General Practice, 2026, 24(1): 67-70. doi: 10.16766/j.cnki.issn.1674-4152.004331
Citation: QIAN Wei, ZHANG Congli, ZHANG Yunchun. Application of Remazolam combined with Esketamine in tonsillar-adenoidectomy in children[J]. Chinese Journal of General Practice, 2026, 24(1): 67-70. doi: 10.16766/j.cnki.issn.1674-4152.004331
shu

Application of Remazolam combined with Esketamine in tonsillar-adenoidectomy in children

doi: 10.16766/j.cnki.issn.1674-4152.004331

  • Department of Anesthesiology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2020A0581

  • Received Date: 2025-01-30
    Available Online: 2026-04-01
    Abstract
  •   Objective  To investigate the effects of remazolam in combination with esketamine on intraoperative haemodynamics, stress response, and postoperative quality of awakening in paediatric tonsillectomy and adenoidectomy.  Methods  In this study, 60 paediatric patients who underwent tonsillectomy and adenoidectomy under general anaesthesia at the First Affiliated Hospital of Bengbu Medical University between January 2023 and December 2023 were selected for the study and randomly divided into two groups: an observation group (Group R) and a control group (Group B), each with 30 patients. In the observation group, remazolam was used for induction and maintenance of anaesthesia; in the control group, propofol was used for induction and maintenance of anaesthesia. The changes in haemodynamic and blood pressure indices were compared between the two groups before induction (T0), during completion of induction (T1), during intubation (T2), during the start of surgery (T3), during removal of the tracheal intubation 10 minutes after the start of surgery (T4) and during withdrawal of the tracheal intubation (T5) as well as at the time of postoperative 15. The changes in haemodynamic and blood pressure indicators, agitation score, and analgesia score 15 minutes (T6) and 30 minutes (T7) postoperatively, the time to extubation, the length of stay in the recovery room (PACU), and the occurrence of adverse reactions during the recovery phase in the two groups were compared.  Results  In group R, blood pressure and heart rate changes at T1-T5 were lower than those in group B, and the difference was statistically significant (P < 0.05). In group R, cortisol (Cor), norepinephrine(NE), and glucose(Glu) were lower in T4 compared to group B. The difference was statistically significant (P < 0.05). The awakening scores of group R at T6 and T7 were lower than those of group B, and the difference was statistically significant (P < 0.05). Extubation time (8.90±1.18) min and PACU length of stay (30.50±2.26) min in group R were shorter than (9.83±1.34) min and (34.47±1.93) min in group B, and the difference was statistically significant (P < 0.05).  Conclusion  The combination of remazolam and esketamine in paediatric tonsillectomy and adenoidectomy can soften the perioperative haemodynamic changes, reduce the intraoperative stress response, and improve the quality of children' s awakening during the recovery period.

     

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