Volume 24 Issue 1
Jan.  2026
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ZHANG Weiping, LUO Song, HUANG Xianjun. Observation on the clinical efficacy of butylphthalide injection in the treatment of acute cerebral infarction[J]. Chinese Journal of General Practice, 2026, 24(1): 71-74. doi: 10.16766/j.cnki.issn.1674-4152.004332
Citation: ZHANG Weiping, LUO Song, HUANG Xianjun. Observation on the clinical efficacy of butylphthalide injection in the treatment of acute cerebral infarction[J]. Chinese Journal of General Practice, 2026, 24(1): 71-74. doi: 10.16766/j.cnki.issn.1674-4152.004332
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Observation on the clinical efficacy of butylphthalide injection in the treatment of acute cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.004332
  • 1.

    Department of Neurology, Tongling People's Hospital (Affiliated Tongling Hospital of Bengbu Medical University), Tongling, Anhui 244000, China

Funds:

 KJ2021A0843

  • Received Date: 2025-07-11
    Available Online: 2026-04-01
    Abstract
  •   Objective  To observe and evaluate the therapeutic effect of butylphthalide injection in the clinical treatment of patients with acute cerebral infarction (ACI).  Methods  A total of 126 ACI patients admitted to Tongling People' s Hospital from June 2021 to June 2024 were selected and divided into an observation group and a control group by a random number table method, with 63 cases in each group. Both groups received conventional drug treatment, while the observation group was additionally given butylphthalide injection for a treatment course of 2 weeks. The National Institutes of Health stroke scale (NIHSS) score, activities of daily living (ADL) score, inflammatory indicators (peripheral blood IL-23 and macrophage inflammatory protein-1α (MIP-1α), oxidative stress indicators superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the nitric oxide (NO) levels, and the adverse reaction rate were statistically compared between the two groups.  Results  The total effective rate in the observation group was 92.06% (58/63), which was significantly higher than 73.02% (46/63) of the control group, with a statistically significant difference (χ2=5.714, P < 0.001). After treatment, the observation group showed significantly lower NIHSS scores (P < 0.01) and significantly higher ADL scores than the control group (P < 0.01), indicating enhanced daily living ability (P < 0.01). In addition, oxidative stress indicators (SOD, GSH-PX and NO levels) were significantly increased (P < 0.01), while inflammatory indicators (IL-23 and MIP-1α levels) were significantly reduced in the observation group (P < 0.01). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).  Conclusion  On the basis of conventional clinical treatment, the addition of butylphthalide injection significantly improves the therapeutic effect, promotes the recovery of neurological function and daily living ability in patients, reduces inflammatory response, inhibits oxidative stress. The treatment demonstrates good safety and contributes to life quality improvement in affected patients.

     

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