Volume 24 Issue 1
Jan.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(1): 75-78
GAO Yuliang, LOU Minfang, HU Ning, YANG Jinmei, WENG Xiaojian, WANG Xiang, SUN Linlin. Therapeutic effect of low-frequency repetitive transcranial magnetic stimulation on non-motor symptoms of Parkinson' s disease[J]. Chinese Journal of General Practice, 2026, 24(1): 75-78. doi: 10.16766/j.cnki.issn.1674-4152.004333
Citation: GAO Yuliang, LOU Minfang, HU Ning, YANG Jinmei, WENG Xiaojian, WANG Xiang, SUN Linlin. Therapeutic effect of low-frequency repetitive transcranial magnetic stimulation on non-motor symptoms of Parkinson' s disease[J]. Chinese Journal of General Practice, 2026, 24(1): 75-78. doi: 10.16766/j.cnki.issn.1674-4152.004333
shu

Therapeutic effect of low-frequency repetitive transcranial magnetic stimulation on non-motor symptoms of Parkinson' s disease

doi: 10.16766/j.cnki.issn.1674-4152.004333

  • Department of Neurology, Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang 324000, China

Funds:

 2022KY1353

 2022K154

  • Received Date: 2025-03-13
    Available Online: 2026-04-01
    Abstract
  •   Objective  To analyze the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on non-motor symptoms in patients with Parkinson' s disease (PD).  Methods  A prospective study was conducted involving 80 PD patients admitted to Quzhou Hospital of Traditional Chinese Medicine from January 2023 to June 2024. The patients were randomly divided into two groups using a random number table: a study group and a control group, with 40 patients in each group. All patients received Madopar treatment. The study group was additionally treated with rTMS, while the control group received sham stimulation. Clinical efficacy, cognitive function, sleep quality, and depression were compared between the two groups.  Results  After treatment, 38 patients in the study group showed improvement, compared to 30 patients in the control group (95.00% vs. 75.00%, P < 0.05). After treatment, scores across all dimensions of cognitive function increased in both groups compared to pre-treatment levels, with the study group exhibiting higher scores than the control group (P < 0.05). The Hamilton depression scale (HAMD) scores decreased in both groups after treatment, with the study group scoring lower than the control group. Conversely, the Parkinson' s disease sleep scale (PDSS) scores increased in both groups after treatment, with the study group scoring higher than the control group (P < 0.05).  Conclusion  Compared to sham stimulation, 0.5 Hz rTMS treatment significantly improves cognitive function, sleep quality, and depression in PD patients, alleviates non-motor symptoms, and leads to better therapeutic outcomes.

     

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